Video Archive
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Tracking Immunoevasion
When cancer cells lose the ability to present neoantigens to immune cells through human leukocyte antigen (HLA) loss, they are able to evade the body’s immune response. Now, Swanton and colleagues present a computational tool that allows researchers to determine whether a tumor has genetic alterations the HLA genes by looking at sequencing data.
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Performing Paper-Based Cell-Free Reactions
In this video, we highlight the simple process of running cell-free transcription and translation reactions on paper substrates. The workflow involves cutting paper discs and placing them into a 384 multiwell plate or custom cartridge, adding a solution containing the cell-free reaction and diagnostic RNA sensors, and then freeze-drying. The resulting reactions are stable at room temperature for distribution and can be activated with the simple addition of water. This video was not peer-reviewed.
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Paper-Based Synthetic Gene Networks Electronic Reader
The portable reader provides a low cost way to quantify our paper-based sensors. It is composed of off-the-shelf electronic components that are housed in a laser-cut acrylic box. Starting at the top of the box, the main components include the: LED layer, cartridge layer, electronic sensor layer and the bottom stack. The bottom stack is composed of an Arduino, data shield and SD card, as well as a battery shield and Li ion battery that can be recharged using a micro-USB. Reactions are read by inserting the cartridge containing the paper-based reactions into the slot between the LED and sensor layers. Once turned on, the reader measures the transmission of light through the paper every minute using an LED with a wavelength that matches the maximum absorbance (570 nm) of the purple toehold switch reporter. This video was not peer-reviewed.
Browse all Cell videosCategories: Research In Action -
Browse all Cell videos
Chronic Stress and Decision-Making
How does chronic stress impact decision making? Ann Graybiel and colleagues demonstrate that chronic stress changes how rats weigh costs and benefits of decisions to seek higher rewards despite higher costs. These behavioral effects are mediated by prefronto-striatal circuit dynamics and can be blocked or mimicked by selective optogenetic manipulation.
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Adjusting the Brain’s GPS
Specific types of neurons in the brain help to calculate and determine our position in space. In this new study, researchers report how specific types of interneurons coordinate the integration of these different types of information.
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Microbiome Gone Wild
Lab mice have been the most common tool to study how the microbiome affects host physiology in health and disease, but do they really represent what’s going on in the real world? A new study surveying the microbiome of a large population of wild-caught mice suggests that this might not be the case.
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How Parakeets Became Blue
Have you ever wondered what is behind the diversity of colors in parrots’ feathers? In this video abstract, Carlos Bustamante and his colleagues tell us how a combination of genetic and biochemical approaches led to a model that may explain natural variations of colors in parakeets and other types of parrots.
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Protein Aggregation Up-Close
Expression of aggregation-prone proteins can cause neurodegeneration. In this video abstract, Rubén Fernández-Busnadiego explains how the latest advances in cryo-electron tomography methods are allowing us to visualize these aggregates at unprecedented resolution and to understand how they disturb cellular function.
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Have You Flossed Your Gut Mucosa Today?
Our mucosal tissues represent the first barrier against microbial invaders. Using advanced intravital live imaging, researchers discover a sophisticated system regulating the dynamic behavior of IELs, the most common type of immune cells surveying the gut mucosa.
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Immunotherapy Goes Viral
Checkpoint blockade therapy is changing the face of cancer treatment, but not every patient responds to immunotherapy and there is urgent need to identify ways to improve its efficacy. In this video abstract, Toni Ribas and his colleagues report the initial results of a clinical trial testing the benefit of combining checkpoint blockade therapy and oncolytic virotherapy in melanoma patients.