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A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

Golub and colleagues
DOI: http://dx.doi.org/10.1016/j.cell.2017.10.049
The next generation Connectivity Map, a large-scale compendium of functional perturbations in cultured human cells coupled to a gene-expression readout, facilitates the discovery of connections between genes, drugs, and diseases.

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A Nobel Pursuit May Not Run like Clockwork
Conversations
DOI: http://dx.doi.org/10.1016/j.cell.2017.11.030

Life Is an N of 1
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Michael Rosbash
DOI: http://dx.doi.org/10.1016/j.cell.2017.11.027

As Time Flew By
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Michael W. Young
DOI: http://dx.doi.org/10.1016/j.cell.2017.11.022

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Tracking Immunoevasion

When cancer cells lose the ability to present neoantigens to immune cells through human leukocyte antigen (HLA) loss, they are able to evade the body’s immune response. Now, Swanton and colleagues present a computational tool that allows researchers to determine whether a tumor has genetic alterations the HLA genes by looking at sequencing data.

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The Ferrous Awakens
DOI: http://dx.doi.org/10.1016/j.cell.2017.11.029
Recent discoveries provide a new hope that relapses of several types of cancer can be prevented by inducing ferroptosis.

The Coming Peptide Tidal Wave
DOI: http://dx.doi.org/10.1016/j.cell.2017.10.010
Design, build, test, repeat—the essence of design thinking and a guiding principle of synthetic biology. Given the complexities of biological systems, there are bottlenecks that slow this virtuous design cycle for many of its potential applications. Yet, in the realm of small protein design and testing, the floodgates have just been thrust open.

A New Model T on the Horizon?
DOI: http://dx.doi.org/10.1016/j.cell.2017.09.011
If you are a cancer researcher, chances are you’ve been asked by your relatives and friends, or even that inquisitive passenger sitting next to you on an airplane, about cures for cancer. Is there one for this cancer? Does that drug really work? Needless to say, the recent success of immune checkpoint inhibitors ignites much discussion and hope. Lately, the curiosity turns to “can you tell me what CAR-T is”?

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