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Molecular Anatomy of the Developing Human Retina
Akina Hoshino, Rinki Ratnapriya, Matthew J. Brooks, Vijender Chaitankar, Matthew S. Wilken, Chi Zhang, Margaret R. Starostik, Linn Gieser, Anna La Torre, Mario Nishio, Olivia Bates, Ashley Walton, Olivia Bermingham-McDonogh, Ian A. Glass, Rachel O.L. Wong, Anand Swaroop, Thomas A. Reh
DOI: http://dx.doi.org/10.1016/j.devcel.2017.10.029
Publication stage: In Press Corrected Proof

E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression
Ana Guarner, Robert Morris, Michael Korenjak, Myriam Boukhali, Maria Paula Zappia, Capucine Van Rechem, Johnathan R. Whetstine, Sridhar Ramaswamy, Lee Zou, Maxim V. Frolov, Wilhelm Haas, Nicholas J. Dyson
DOI: http://dx.doi.org/10.1016/j.devcel.2017.11.008
Publication stage: In Press Corrected Proof
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A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size

Peng Zhang, Chunli Pei, Xi Wang, Jinyi Xiang, Bao-Fa Sun, Yongsheng Cheng, Xiaolong Qi, Marco Marchetti, Jia-Wei Xu, Ying-Pu Sun, Bruce A. Edgar, Zengqiang Yuan
DOI: http://dx.doi.org/10.1016/j.devcel.2017.10.033
Open Access
Zhang et al. uncover a mechanism whereby Drosophila RBF, via E2F1, regulates Hippo signaling by modulating the formation of Yki/Sd complexes, thereby controlling Yki transcriptional outputs and apoptosis, organ size, and gut homeostasis regulation. The RB and E2F interaction is conserved in human cells and may broadly impact tissue homeostasis.

Macrophage-Dependent Cytoplasmic Transfer during Melanoma Invasion In Vivo

Minna Roh-Johnson, Arish N. Shah, Jason A. Stonick, Kumud R. Poudel, Julia Kargl, Grace H. Yang, Julie di Martino, Rafael E. Hernandez, Charles E. Gast, Luai R. Zarour, Susumu Antoku, A. McGarry Houghton, Jose Javier Bravo-Cordero, Melissa H. Wong, John Condeelis, Cecilia B. Moens
DOI: http://dx.doi.org/10.1016/j.devcel.2017.11.003
Roh-Johnson et al. show that macrophages transfer cytoplasmic molecules to tumor cells via cell contact in zebrafish and mouse. Cytoplasmic transfer correlates with increased tumor cell dissemination in vivo and altered tumor cell migration in vitro. These results uncover a mode of contact-dependent cell-to-cell communication in the tumor microenvironment.

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An In Toto Approach to Dissecting Cellular Interactions in Complex Tissues



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Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations



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Catenins Steer Cell Migration via Stabilization of Front-Rear Polarity



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