Natural disasters linked to contexts of unpredictability and surprise generate a climate of uncertainty in the population, resulting in an exponential increase in disinformation. These are crisis situations that cause the management of public and governmental institutions to be questioned, diminish citizens’ trust in the media, and reinforce anonymity in social networks. New digital algorithms create a scenario plagued by fake news and levels of viralization of rumors never before contemplated. Our objective is to analyze the verification capacity of fact-checking agencies at X at times of information disorder, such as the Turkey–Syria earthquakes in 2023. We apply a mixed methodology of comparative content analysis to government, news agency, and IFCN accounts, generating a general sample (n = 46,747) that is then subjected to thematic categorization to create a specific sample (n = 564). The results indicate a low commitment to fact-checking on the part of official bodies and news agencies, as opposed to fact-checking agencies’ accurate handling of the facts. The lack of debate and engagement generated by digital audiences in the face of the discursive intentionality of disinformation is significant. Full article

The pilot study assessed the utility of a training program using modified, commercially available dual-joystick-operated ride-on toys to promote unimanual and bimanual upper extremity (UE) function in children with cerebral palsy (CP). The ride-on-toy training was integrated within a 3-week, intensive, task-oriented training camp for children with CP. Eleven children with hemiplegia between 4 and 10 years received the ride-on-toy training program 20–30 min/day, 5 days/week for 3 weeks. Unimanual motor function was assessed using the Quality of Upper Extremity Skills Test (QUEST) before and after the camp. During ride-on-toy training sessions, children wore activity monitors on both wrists to assess the duration and intensity of bimanual UE activity. Video data from early and late sessions were coded for bimanual UE use, independent navigation, and movement bouts. Children improved their total and subscale QUEST scores from pretest to post-test while increasing moderate activity in their affected UE from early to late sessions, demonstrating more equal use of both UEs across sessions. There were no significant changes in the rates of movement bouts from early to late sessions. We can conclude that joystick-operated ride-on toys function as child-friendly, intrinsically rewarding tools that can complement conventional therapy and promote bimanual motor functions in children with CP. Full article

Vaccines prevent a significant number of deaths annually. However, certain populations do not respond adequately to vaccination due to impaired immune systems. Cirrhosis, a condition marked by a profound disruption of immunity, impairs the normal immunization process. Critical vaccines for cirrhotic patients, such as the hepatitis A virus (HAV), hepatitis B virus (HBV), influenza, pneumococcal, and coronavirus disease 19 (COVID-19), often elicit suboptimal responses in these individuals. The humoral response, essential for immunization, is less effective in cirrhosis due to a decline in B memory cells and an increase in plasma blasts, which interfere with the creation of a long-lasting response to antigen vaccination. Additionally, some T cell subtypes exhibit reduced activation in cirrhosis. Nonetheless, the persistence of memory T cell activity, while not preventing infections, may help to attenuate the severity of diseases in these patients. Alongside that, the impairment of innate immunity, particularly in dendritic cells (DCs), prevents the normal priming of adaptive immunity, interrupting the immunization process at its onset. Furthermore, cirrhosis disrupts the gut–liver axis balance, causing dysbiosis, reduced production of short-chain fatty acids (SCFAs), increased intestinal permeability, and bacterial translocation. Undermining the physiological activity of the immune system, these alterations could impact the vaccine response. Enhancing the understanding of the molecular and cellular factors contributing to impaired vaccination responses in cirrhotic patients is crucial for improving vaccine efficacy in this population and developing better prevention strategies. Full article

Penicillium digitatum is the causal agent of green mold, a primary postharvest disease of citrus fruits. This study evaluated the efficacy of a novel photoactive chitosan–riboflavin bioconjugate (CH-RF) to control green mold in vitro and in lemon fruit. The results showed total inhibition of P. digitatum growth on APDA supplemented with CH-RF at 0.5% (w/v) and a significant reduction of 84.8% at 0.25% (w/v). Lemons treated with CH-RF and kept under controlled conditions (20 °C and 90–95% relative humidity) exhibited a noteworthy reduction in green mold incidence four days post-inoculation. Notably, these effects persisted, with all treatments remaining significantly distinct from the control group until day 14. Furthermore, CH-RF showed high control of green mold in lemons after 20 days of cold storage (5 ± 1 °C). The disease incidence five days after cold storage indicated significant differences from the values observed in the control. Most CH-RF treatments showed enhanced control of green mold when riboflavin was activated by white-light exposure. These findings suggest that this novel fungicide could be a viable alternative to conventional synthetic fungicides, allowing more sustainable management of lemon fruit diseases. Full article

The article aims to identify how systemic, multi-scale dynamics influence access to adequate and healthy food and eating and how food is produced and circulated in the Amazonian context of the Metropolitan Region of Santarém (PA). We conducted a literature review, qualitative interviews with key actors, discussion groups and visits to food retailers to address the following research questions: how do socio-economic and political dynamics, especially those related to the soy-meat agroindustrial complex, create or reproduce social inequalities, injustices and inequities, and how do they affect the access to adequate and healthy food? Our findings suggest that the expansion of large-scale soybean growing and livestock, forming the industrial soy-meat complex, contributes to the impoverishment of certain social segments of the local population, accompanied by the erosion of the base for food production. Smallholder farmers and Indigenous and traditional people are among the main affected groups, while violence in rural areas contributes to restricting access to adequate and healthy food. The novelties of our study lie in approaching food systems, taking access to food as the entry point and linking adverse effects of the soy-meat complex to inequalities in access to healthy food. The study also discusses value conflicts between “traditional” and “modern food” (e.g., ultra-processed food), reflecting intergenerational disputes between ways of life and culture, which are also nurtured by the expansion of the soy-meat complex. These multi-scale dynamics have significant repercussions on how food is produced and circulated and highlight the relations between local food politics and conflicts, as well as their connections with processes beyond the local scale. Finally, the article calls for advancing integrated and multi-scale analysis of food production and access to address challenges of social injustices in food system transitions, fostering sustainability, human health and climate change mitigation and adaptation. Full article

Rabbit hemorrhagic disease (RHD) is an acute fatal disease caused by the rabbit hemorrhagic disease virus (RHDV). Since the first outbreaks of type 2 RHDV (RHDV2) in April 2020 in China, the persistence of this virus in the rabbit population has caused substantial economic losses in rabbit husbandry. Previous failures in preventing RHDV2 prompted us to further investigate the immune mechanisms underlying the virus’s pathogenicity, particularly concerning the spleen, a vital component of the mononuclear phagocyte system (MPS). For this, a previous RHDV2 isolate, CHN/SC2020, was utilized to challenge naive adult rabbits. Then, the splenic transcriptome was determined by RNA-Seq. This study showed that the infected adult rabbits had 3148 differentially expressed genes (DEGs), which were associated with disease, signal transduction, cellular processes, and cytokine signaling categories. Of these, 100 upregulated DEGs were involved in inflammatory factors such as IL1α, IL-6, and IL-8. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that these DEGs were significantly enriched in the cytokine–cytokine receptor interaction signaling pathway, which may play a vital role in CHN/SC2020 infection. At the same time, proinflammatory cytokines and chemokines were significantly increased in the spleen at the late stages of infection. These findings suggested that RHDV2 (CHN/SC2020) might induce dysregulation of the cytokine network and compromise splenic immunity against viral infection, which expanded our understanding of RHDV2 pathogenicity. Full article

Selenomonas noxia, a gram-negative anaerobe usually present in periodontitis, may be linked to overweight and obese adults. Recent advancements include a valid qPCR screening, enabling an effective prevalence study among pediatric patients aged 7 to 17 years. The aim of this study was to complete a retrospective screening of saliva samples from an existing biorepository using a validated qPCR screening protocol. The pediatric study sample (n = 87) comprised nearly equal numbers of males and females, mostly minority patients (67%), with an average age of 13.2 years. Screening for Selenomonas noxia revealed 34.4% (n = 30/87) positive samples, evenly distributed between males and females (p = 0.5478). However, an age-dependent association was observed with higher percentages of positive samples observed with higher ages (13.3% among 7 to 10 years; 34.6% among 11 to 13 years; 54.8% among 14–17 years), which was statistically significant (p = 0.0001). Although these findings revealed no noteworthy distinctions between males or females and minorities and non-minorities, the notable contrast between younger (7 to 10 years) and older (11 to 17 years) participants, possibly influenced by factors such as hormones and behavioral traits, will require further investigation of this patient population. Full article

The precast concrete production process faces uncertainties and risks that reduce the efficiency of the Saudi precast concrete industry. Assessing the risk factors’ interdependence yields better results than considering individual analyses only. The previous precast risk studies did not consider the interdependencies among risk factors concerning different process stages. This paper aims to identify precast risk factors and prioritize their importance in Saudi Arabia. Using a dynamic Bayesian network, the assessment considers the interrelationships among the risk factors and different production stages. The risk factors were collected from previous studies, evaluated, and classified into the five construction stages by performing structured interviews with ten experts. The probabilities of the root risks and conditional probabilities of intermediate and leaf risks were assessed based on the ten experts. Then, a Monte Carlo simulation was utilized to provide the status of these probabilities, which were considered input data for the GeNIe program. The main results revealed that erection productivity is the highest risk, with a probability value of 0.87. In addition, the design schedule’s significance directly impacts production capacity, resulting in a probability value of 0.74. However, the site management risk is low, with a 0.32 probability value. This paper assists practitioners in optimizing construction schedules. Full article

Obesity has a great impact on adipose tissue biology, based on its function as a master regulator of energy balance. Brown adipose tissue (BAT) undergoes remodeling, and its activity declines in obese subjects due to a whitening process. The anti-obesity properties of fruit extracts have been reported. The effects of tart cherry against oxidative stress, inflammation, and the whitening process in the BAT of obese rats were investigated. Intrascapular BAT (iBAT) alterations and effects of Prunus cerasus L. were debated in rats fed for 17 weeks with a high-fat diet (DIO), in DIO supplemented with seed powder (DS), and with seed powder plus the juice (DJS) of tart cherry compared to CHOW rats fed with a normo-caloric diet. iBAT histologic observations revealed a whitening process in DIO rats that was reduced in the DS and DJS groups. A modulation of uncoupling protein-1 (UCP-1) protein and gene expression specifically were detected in the obese phenotype. An upregulation of UCP-1 and related thermogenic genes after tart cherry intake was detected compared to the DIO group. Metabolic adjustment, endoplasmic reticulum stress, protein carbonylation, and the inflammatory microenvironment in the iBAT were reported in DIO rats. The analysis demonstrated an iBAT modulation that tart cherry promoted. In addition to our previous results, these data confirm the protective impact of tart cherry consumption on obesity. Full article

Curcumin (CUR) is a lipophilic natural polyphenol that can be isolated from the rhizome of turmeric. Studies have proposed that CUR possesses a variety of biological activities. Due to its anti-inflammatory and antioxidant properties, CUR shows promise in the treatment of inflammatory bowel disease, while its anti-obesity effects make it a potential therapeutic agent in the management of obesity. In addition, curcumin’s ability to prevent atherosclerosis and its cardiovascular benefits further expand its potential application in the treatment of cardiovascular disease. Nevertheless, owing to the limited bioavailability of CUR, it is difficult to validate its specific mechanism of action in the treatment of diseases. However, the restricted bioavailability of CUR makes it challenging to confirm its precise mode of action in disease treatment. Recent research indicates that the oral intake of curcumin may lead to elevated levels of residual curcumin in the gastrointestinal system, hinting at curcumin’s potential to directly influence gut microbiota. Furthermore, the ecological dysregulation of the gut microbiota has been shown to be critical in the pathogenesis of human diseases. This review summarizes the impact of gut dysbiosis on host health and the various ways in which curcumin modulates dysbiosis and ameliorates various diseases caused by it through the administration of curcumin. Full article

During the last decades, forest soils in Central Europe recovered from former sulfur and acid deposition. As external S input into forests has strongly decreased and legacy S pools in the soils are diminishing, internal S cycling through mineralization will increasingly become important for ecosystem nutrition. However, it is not known how microbial biomass is affected by the S pool change in the formerly S surplus soils. Here, we present data on the status quo of C, N, and S in microbial biomass in relation to contents in mineral soil and organic layer. The results of forest soil in Eastern Germany (low and high liming), which is slowly recovering from former pollution, are compared to those of a site remote from air pollution in the Swiss Alps. The contents of C, N, and S in soil as well as in microbial biomass were clearly higher in the organic layer than in mineral topsoil at all sites. Despite the generally low content in the mineral A-horizon, the clean-air site showed indications of a more active S-turnover as compared to the high-pollution site. Liming at the high-pollution site improved the conditions for microbial growth (pH increase) in the organic layer resulting in more mobile S. Full article

Objectives: To report the relationships of major dietary fatty acids with major cardiovascular disease mortality groups in a cohort of middle-aged men followed up with until extinction. Material and Methods: In the early 1960s, a cohort of men aged 40 to 59 years was enrolled and examined within the Italian Rural Areas section of the Seven Countries Study including dietary history that allowed for the estimation of major fatty acid (FA) intake (saturated FAs: SAFAs; mono-unsaturated FAs: MUFAs; and poly-unsaturated FAs: PUFAs), their ratios, and the production of a dietary score derived from 18 food groups, the high levels of which corresponded to a Mediterranean diet profile. Results: During a follow-up of 61 years, the intake of SAFAs was directly while that of MUFAs was inversely and significantly associated with coronary heart disease (CHD) mortality (the hazard ratio for one standard deviation was 1.28 and 0.84, respectively) but not with other cases of Heart Disease of Uncertain Etiology (HDUE) and stroke mortality. The hazard ratio for SAFAs remained significant after factoring into the multivariate models the dietary score and other classical cardiovascular risk factors (age, smoking habits, cholesterol levels, and systolic blood pressure). The role of the dietary score was inverse and significant (hazard ratio of 0.73). Again, this was true for CHD but not for HDUE and stroke mortality. Conclusions: Both SAFAs and MUFAs predict long-term CHD mortality, together with a dietary score, but not HDUE and stroke, which represent different diseases also in relation to dietary habits. Full article

The Chinese manufacturing industry faces many challenges to sustainable development. This study examines how transformational leadership, corporate culture, and digital transformation affect Chinese manufacturing organizations’ sustainability. It will also examine the moderating role of environmental dynamism and the mediating effect of innovation capabilities. A self-administered survey was distributed to 350 manufacturing companies’ owners, managers, leaders, and employees, etc. Participants were selected via convenient sampling. This data collection effort validated findings and empirically tested theories. Smart PLS structural equation modelling (PLS-SEM), quantitative research, and cross-research are used in this study. The findings suggest that corporate culture, transformational leadership, and digital transformation significantly affect organizations’ sustainability. Innovation capability does not affect the relationship between corporate culture and sustainability. However, it mediates the relationship between transformational leadership, digital transformation, and business sustainability. Innovation capabilities and business sustainability performance are moderated by environmental dynamism. This study contributes to sustainable corporate performance theory by showing managers how transformational leadership, digital transformation, and corporate culture can help manufacturing companies grow indefinitely. The findings have major implications for China, a highly industrialized nation. This study could benefit regulatory authorities, academic institutions, industry, government agencies, and researchers. Full article

With the rapid development of advanced technologies, such as artificial intelligence and deep learning, educational informatization has entered a new era. However, the explosion of information has brought numerous challenges. Knowledge graphs, as a crucial component of artificial intelligence, can contribute to the quality of teaching. This study proposes an educational knowledge graph based on course information named CourseKG for precision teaching. Precision teaching seeks to individualize the curriculum for each learner and optimize learning efficiency. CourseKG aims to establish a correct and comprehensive curriculum knowledge system and promote personalized learning paths. CourseKG can address the issue that current general-purpose knowledge graphs are not suitable for the education field. Particularly, this study proposes a framework for educational entity recognition based on the pre-trained BERT model. This framework captures relevant information in the educational domain using the BERT model and combines it with the BiGRU and multi-head self-attention mechanism to extract multi-scale and multi-level global dependency relationships. In addition, the CRF is used for character-label decoding. Further, a relationship extraction method based on the BERT model, which integrates sentence features and educational entities and estimates the similarity between knowledge pairs using cosine similarity, is proposed. The proposed CourseKG is verified by experiments using real-world C programming course data. The experimental results demonstrate the effectiveness of CourseKG. Finally, the results show that the proposed CourseKG can significantly enhance the precision teaching quality and realize multi-directional adaptation among teachers, courses, and students. Full article

After the excavation and unloading of deep-buried soft rock tunnels, support structures often experience deformation-related disasters such as concrete cracking, steel frame bending and twisting, and primary support instability under different forms of load. Accurately calculating the load borne by the primary support structure is the key to ensuring design rationality and construction safety. Especially in layered soft surrounding rock formations, the magnitude and distribution of the loads are different from those of conventional rock and soil masses, resulting in limited applicability of existing load calculation methods to similar formations. Therefore, based on the measured deformation of the tunnel structure, while considering the different geometric forms of the primary support structure during partial excavation, this paper proposes a deformation-structure (D-S) load calculation method. By comparing the calculation results of this method and a large number of sample data for typical deep-buried layered soft rock tunnels, the reliability of the D-S load calculation method is verified. In addition, the variation law of the loads during the tunnel construction period is enunciated, and the magnitude and distribution of the loads acting on the primary support are clarified. The D-S load calculation method provides a theoretical basis for load calculation in deep-buried layered soft rock tunnels. Full article

This article proposes the creation of a participatory governance framework for traditional communities, focusing on financial benefits sharing, whether they come from compensation, indemnification, or socio-environmental projects. The proposed governance framework was developed based on a series of governance principles and the perceptions and needs of fourteen traditional communities in the Brazilian Amazon. The results demonstrated that applied experiences were successful. In this way, the proposed framework presents itself as a mechanism that can be adapted to the specifics of managing financial resources in community contexts. Full article

The pivotal role of farmers’ cropland conservation behavior (CCB) in advancing green agricultural practices is well-recognized. This paper underscores the critical role of stable land tenure in enhancing farmers’ CCB, exemplified by the practice of mulch recycling. Drawing on a survey of 349 cotton farmers in Xinjiang, Northwest China, it offers a systematic examination of how land tenure stability influences CCB and its underlying mechanisms. The findings reveal a significant positive correlation between land tenure stability and CCB. Notably, this relationship is mediated by the facilitation of land mortgages, wherein written contracts and extended land tenure durations enhance farmers’ participation in land mortgages, thereby bolstering CCB. Furthermore, the stabilizing effect of land tenure on CCB also mitigates the negative impacts of risk aversion and time preference. The study additionally highlights the differential effects of land tenure stability based on farm size and technical training; its facilitative role in CCB is more pronounced among larger-scale farmers and those engaged in technical training. Full article

(1) Background: Inflammatory bowel disease (IBD) is frequently associated to other immune-mediated inflammatory diseases (IMIDs). This study aims at assessing physicians’ awareness of the issue and the current status of IMID management. (2) Methods: A web-based survey was distributed to all 567 physicians affiliated to IG-IBD. (3) Results: A total of 249 (43.9%) physicians completed the survey. Over 90% of the responding physicians were gastroenterology specialists, primarily working in public hospitals. About 51.0% of the physicians had access to an integrated outpatient clinic, where gastroenterologists collaborated with rheumatologists and 28.5% with dermatologists. However, for 36.5% of physicians, integrated ambulatory care was not feasible. Designated appointment slots for rheumatologists and dermatologists were accessible to 72.2% and 58.2% of physicians, respectively, while 20.1% had no access to designated slots. About 5.2% of physicians report investigating signs or symptoms of IMIDs only during the initial patient assessment. However, 87.9% inquired about the presence of concomitant IMIDs at the initial assessment and actively investigated any signs or symptoms during subsequent clinical examination. (4) Conclusions: While Italian physicians recognize the importance of IMIDs associated with IBD, organizational challenges impede the attainment of optimal multidisciplinary collaboration. Efforts should be directed toward enhancing practical frameworks to improve the overall management of these complex conditions. Full article

Intravitreal aflibercept injection (IAI) is a treatment for diabetic macular edema (DME), but its mechanism of action (MoA) has not been completely elucidated. Here, we aimed to explore IAI’s MoA and its multi-target nature in DME pathophysiology with an in silico (computer simulation) disease model. We used the Therapeutic Performance Mapping System (Anaxomics Biotech property) to generate mathematical models based on the available scientific knowledge at the time of the study, describing the relationship between the modulation of vascular endothelial growth factor receptors (VEGFRs) by IAI and DME pathophysiological processes. We also undertook an enrichment analysis to explore the processes modulated by IAI, visualized the effectors’ predicted protein activity, and specifically evaluated the role of VEGFR1 pathway inhibition on DME treatment. The models simulated the potential pathophysiology of DME and the likely IAI’s MoA by inhibiting VEGFR1 and VEGFR2 signaling. The action of IAI through both signaling pathways modulated the identified pathophysiological processes associated with DME, with the strongest effects in angiogenesis, blood–retinal barrier alteration and permeability, and inflammation. VEGFR1 inhibition was essential to modulate inflammatory protein effectors. Given the role of VEGFR1 signaling on the modulation of inflammatory-related pathways, IAI may offer therapeutic advantages for DME through sustained VEGFR1 pathway inhibition. Full article

Curcumin is a polyphenolic molecule derived from the rhizoma of Curcuma longa L. This compound has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties. These make it ideal for preventing and treating skin inflammation, premature skin ageing, psoriasis, and acne. Additionally, it exhibits antiviral, antimutagenic, and antifungal effects. Curcumin provides protection against skin damage caused by prolonged exposure to UVB radiation. It reduces wound healing times and improves collagen deposition. Moreover, it increases fibroblast and vascular density in wounds. This review summarizes the available information on the therapeutic effect of curcumin in treating skin diseases. The results suggest that curcumin may be an inexpensive, well-tolerated, and effective agent for treating skin diseases. However, larger clinical trials are needed to confirm these observations due to limitations in its in vivo use, such as low bioavailability after oral administration and metabolism. Full article

To improve energy and environmental security in urban environments and in accordance with the requirements of the EU, the task of sustainable developing agriculture in urban agglomerations and monitoring it using satellite images becomes relevant. The aim of the work is the development of methods and means for determining stable islands of thermal energy to substantiate the optimal locations for plant growing practices in the metropolis. The research was conducted in Kyiv, the largest metropolis of Ukraine. Data from the Landsat 8 and 9 satellites were used because of the free data and they have better spatial resolution and an available archive of observation results. It was established that the temperature map of the city of Kyiv shows differences in temperature between different parts of the city, probably due to the presence of different sources of heat radiation. It is obvious that the standard deviation of the temperature in the plots depends on many factors, in particular, the season and the type of land use. It is necessary to find alternative solutions for the development of crop production in this area, taking into account the characteristics of thermal emissions. Based on software products from free satellite monitoring providers, EO Browser, a specialized software solution (web application) has been created for monitoring agricultural plantations in an urban environment. A collection of LANDSAT 8 satellite images was used. Areas with stable heat emissions were found, which are due to the operation of a modern shopping and entertainment center, and non-traditional crops for landscaping adapted to its design are proposed. As a result of research, strong heat emissions were recorded for some objects, for them the temperature exceeds the surrounding area by 4 °C, while the minimum standard deviation in January is 0.5 °C, the maximum in July is 2.8 °C, in April and October—1.7 °C and 1.2 °C, respectively. Full article