| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Jared Goff |
1. Jared Goff, QB | DET | W 34-17 at CHI | 23 | 32 | 336 | 3 | 0 | 1 | 0 | 137.0 |
| 2. Caleb Williams, QB | CHI | L 34-17 vs. DET | 26 | 40 | 334 | 2 | 0 | 2 | 1 | 107.7 | |
| 3. Geno Smith, QB | SEA | L 27-24 vs. MIN | 31 | 43 | 314 | 3 | 2 | 2 | 0 | 96.5 | |
| 4. Brock Purdy, QB | SF | L 29-17 at MIA | 26 | 40 | 313 | 2 | 1 | 3 | 0 | 95.1 | |
| 5. Baker Mayfield, QB | TB | L 26-24 at DAL | 31 | 43 | 303 | 2 | 1 | 4 | 0 | 97.3 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Jonathan Taylor |
1. Jonathan Taylor, RB | IND | W 38-30 vs. TEN | 29 | 218 | 7.5 | 3 | 70 | 0 | |
| 2. Derrick Henry, RB | BAL | W 34-17 vs. PIT | 24 | 162 | 6.8 | 0 | 44 | 0 | ||
| 3. Chuba Hubbard, RB | CAR | W 36-30 vs. ARI | 25 | 152 | 6.1 | 2 | 28 | 0 | ||
| 4. Saquon Barkley, RB | PHI | L 36-33 at WSH | 29 | 150 | 5.2 | 2 | 68 | 0 | ||
| 5. Kyren Williams, RB | LAR | W 19-9 at NYJ | 23 | 122 | 5.3 | 1 | 13 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Justin Jefferson |
1. Justin Jefferson, WR | MIN | W 27-24 at SEA | 10 | 144 | 14.4 | 2 | 39 | 0 | |
| 2. Jameson Williams, WR | DET | W 34-17 at CHI | 5 | 143 | 28.6 | 1 | 82 | 0 | ||
| 3. Keenan Allen, WR | CHI | L 34-17 vs. DET | 9 | 141 | 15.7 | 1 | 45 | 0 | ||
| 4. Brian Thomas Jr., WR | JAX | L 19-14 at LV | 9 | 132 | 14.7 | 1 | 62 | 0 | ||
| 5. George Kittle, TE | SF | L 29-17 at MIA | 8 | 106 | 13.3 | 0 | 28 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Eric Murray |
1. Eric Murray, S | HOU | L 27-19 at KC | 8 | 2 | 10 | 0.0 | 0 | 0 | 0 |
| 2. Brandon Jones, S | DEN | L 34-27 at LAC | 7 | 3 | 10 | 0.0 | 0 | 0 | 0 | |
| 3. Daiyan Henley, LB | LAC | W 34-27 vs. DEN | 7 | 3 | 10 | 0.0 | 0 | 0 | 0 | |
| 4. Roquan Smith, LB | BAL | W 34-17 vs. PIT | 5 | 5 | 10 | 0.0 | 0 | 0 | 0 | |
| 5. Henry To'oTo'o, LB | HOU | L 27-19 at KC | 5 | 5 | 10 | 0.0 | 0 | 0 | 0 | |