Mike Love

@mikelove

Assist. Prof, Biostat, Genetics @ UNC-Chapel Hill, Member of LCCC. Biostatistics, Computational Biology,

Chapel Hill, NC
כאן מאז דצמבר 2006

ציוצים

חסמת את @mikelove

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  1. צייץ מחדש
    לפני 11 שעות

    Our new paper: Using Equivalent Class counts directly for testing differential transcript usage. Nice work from

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  2. צייץ מחדש
    18 בדצמ׳

    The decontam method introduced in our new paper is available as an R package via Bioconductor and has an annotated tutorial. Bioconductor: Tutorial: Manuscript:

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  3. צייץ מחדש
    18 בדצמ׳

    Our intensely collaborative (5/6 authors are PIs!) review article *for biologists* about theory / mathematical modeling is out in JCS: Unite to divide – how models and biological experimentation have come together to reveal mechanisms of cytokinesis

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  4. צייץ מחדש
    17 בדצמ׳

    Congrats and Nicole Davis: really useful piece of work: Simple statistical identification and removal of contaminant sequences in marker-gene and metagenomics data

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  5. צייץ מחדש
    17 בדצמ׳

    PSA: The incoming CRAN submission queue will be closed from Dec 21 to Jan 2 (assumedly for a well deserved break for the volunteer team). Get your new packages and updates in before the 21st or wait until the new year.

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  6. צייץ מחדש
    17 בדצמ׳

    Alevin efficiently estimates accurate gene abundances from dscRNA-seq data I was pleased to see this! Nicely solves an unsightly hack in UMI-based scRNAseq.

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  7. צייץ מחדש
    17 בדצמ׳
    בתשובה ל-

    In stat method life and then in R pkg life, I had to intentionally cultivate a neutral-to-positive attitude re: what others were doing — especially if the work is adjacent to mine. We’re embarked on a collective effort! This makes me much happier and more productive too.

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  8. צייץ מחדש
    16 בדצמ׳

    Our integrative study on dozens of in vivo RNA-binding protein datasets is out! A long standing collaboration with Tom Tuschl and fantastic work led by . I think of it as renegade inofficial companion paper 😇

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  9. צייץ מחדש
    15 בדצמ׳

    Very excited to be leading our new Translational Integrated Research Center at So many opportunities in this space bridging many disciplines with terrific computational/experimental investigators. Stay tuned!

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  10. צייץ מחדש
    15 בדצמ׳

    CancerInSilico: An R/Bioconductor package for combining mathematical and statistical modeling to simulate time course bulk and single cell gene expression data in cancer | bioRxiv

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  11. צייץ מחדש
    14 בדצמ׳

    Polygenic risk scores for breast cancer and estrogen-receptor subtypes, developed using individual-level data on 170,000 cases and controls from the Breast Cancer Association Consortium. 313 SNPs can identify 1% of women at 4.3-fold increased risk of ER+ disease.

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  12. 14 בדצמ׳

    if you use NNLS for deconvolution, you should be adding expression profiles on the raw expression scale, not log scale. we have a helper function unmix() for making comparisons in log-like scale while doing the NNLS on the raw, easy to copy the code and modify

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  13. צייץ מחדש
    14 בדצמ׳

    Breast cancer screening is one of the most tractable uses of risk scoring. Improved predictions, with 32% BC risk in highest 1% PRS.

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  14. צייץ מחדש
    13 בדצמ׳

    Wow. PsychEncode just flooded the science publication group with 10 manuscripts revealing a significant progress made towards understanding the brain's molecular architecture. They dedicate this release to

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  15. צייץ מחדש
    14 בדצמ׳

    Random thoughts about confidence intervals: When we teach precision & accuracy, we often use images of a target, like these from the Wikipedia article: But I think this analogy leads to confusion about the interpretation of the confidence interval. 1/4

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  16. צייץ מחדש
    13 בדצמ׳

    Using multiple measurements of tissue to estimate cell-type-specific gene expression via deconvolution

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  17. צייץ מחדש
    13 בדצמ׳

    Our study with on pup recognition just out! Check it out in the following links: or

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  18. צייץ מחדש
    3 בספט׳

    Check out our new ENIGMA GWAS: Common genetic variants impacting the structure of the human cerebral cortex, measured with MRI, in 35k humans, ~200 loci:

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  19. צייץ מחדש
    14 בדצמ׳

    The Brain Transcriptome maps are finally out! This includes some of the RNA-seq data back from my post-doc in 2008 with ! Revealing the brain's molecular architecture, one transcript at a time - see here

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  20. צייץ מחדש
    13 בדצמ׳

    Important session at this morning - a discussion of the need for greater diversity in human genetics, led by . She leads off with a pretty astonishing statistic: Europeans are 80% of samples in genetic studies, vs 16% of the global population.

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