Mike Love

@mikelove

Assist. Prof, Biostat, Genetics @ UNC-Chapel Hill, Member of LCCC. Biostatistics, Computational Biology,

Chapel Hill, NC
Liittynyt joulukuu 2006

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  1. uudelleentwiittasi
    11 tuntia sitten

    Our new paper: Using Equivalent Class counts directly for testing differential transcript usage. Nice work from

    Kumoa
  2. uudelleentwiittasi
    18. jouluk.

    The decontam method introduced in our new paper is available as an R package via Bioconductor and has an annotated tutorial. Bioconductor: Tutorial: Manuscript:

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    Kumoa
  3. uudelleentwiittasi
    18. jouluk.

    Our intensely collaborative (5/6 authors are PIs!) review article *for biologists* about theory / mathematical modeling is out in JCS: Unite to divide – how models and biological experimentation have come together to reveal mechanisms of cytokinesis

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    Kumoa
  4. uudelleentwiittasi
    17. jouluk.

    Congrats and Nicole Davis: really useful piece of work: Simple statistical identification and removal of contaminant sequences in marker-gene and metagenomics data

    Kumoa
  5. uudelleentwiittasi
    17. jouluk.

    PSA: The incoming CRAN submission queue will be closed from Dec 21 to Jan 2 (assumedly for a well deserved break for the volunteer team). Get your new packages and updates in before the 21st or wait until the new year.

    Kumoa
  6. uudelleentwiittasi
    17. jouluk.

    Alevin efficiently estimates accurate gene abundances from dscRNA-seq data I was pleased to see this! Nicely solves an unsightly hack in UMI-based scRNAseq.

    Kumoa
  7. uudelleentwiittasi
    17. jouluk.
    Vastauksena käyttäjälle

    In stat method life and then in R pkg life, I had to intentionally cultivate a neutral-to-positive attitude re: what others were doing — especially if the work is adjacent to mine. We’re embarked on a collective effort! This makes me much happier and more productive too.

    Kumoa
  8. uudelleentwiittasi
    16. jouluk.

    Our integrative study on dozens of in vivo RNA-binding protein datasets is out! A long standing collaboration with Tom Tuschl and fantastic work led by . I think of it as renegade inofficial companion paper 😇

    Kumoa
  9. uudelleentwiittasi
    15. jouluk.

    Very excited to be leading our new Translational Integrated Research Center at So many opportunities in this space bridging many disciplines with terrific computational/experimental investigators. Stay tuned!

    Kumoa
  10. uudelleentwiittasi
    15. jouluk.

    CancerInSilico: An R/Bioconductor package for combining mathematical and statistical modeling to simulate time course bulk and single cell gene expression data in cancer | bioRxiv

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    Kumoa
  11. uudelleentwiittasi
    14. jouluk.

    Polygenic risk scores for breast cancer and estrogen-receptor subtypes, developed using individual-level data on 170,000 cases and controls from the Breast Cancer Association Consortium. 313 SNPs can identify 1% of women at 4.3-fold increased risk of ER+ disease.

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    Kumoa
  12. 14. jouluk.

    if you use NNLS for deconvolution, you should be adding expression profiles on the raw expression scale, not log scale. we have a helper function unmix() for making comparisons in log-like scale while doing the NNLS on the raw, easy to copy the code and modify

    Kumoa
  13. uudelleentwiittasi
    14. jouluk.

    Breast cancer screening is one of the most tractable uses of risk scoring. Improved predictions, with 32% BC risk in highest 1% PRS.

    Kumoa
  14. uudelleentwiittasi
    13. jouluk.

    Wow. PsychEncode just flooded the science publication group with 10 manuscripts revealing a significant progress made towards understanding the brain's molecular architecture. They dedicate this release to

    Kumoa
  15. uudelleentwiittasi
    14. jouluk.

    Random thoughts about confidence intervals: When we teach precision & accuracy, we often use images of a target, like these from the Wikipedia article: But I think this analogy leads to confusion about the interpretation of the confidence interval. 1/4

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    Kumoa
  16. uudelleentwiittasi
    13. jouluk.

    Using multiple measurements of tissue to estimate cell-type-specific gene expression via deconvolution

    Kumoa
  17. uudelleentwiittasi
    13. jouluk.

    Our study with on pup recognition just out! Check it out in the following links: or

    Kumoa
  18. uudelleentwiittasi
    3. syysk.

    Check out our new ENIGMA GWAS: Common genetic variants impacting the structure of the human cerebral cortex, measured with MRI, in 35k humans, ~200 loci:

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    Kumoa
  19. uudelleentwiittasi
    14. jouluk.

    The Brain Transcriptome maps are finally out! This includes some of the RNA-seq data back from my post-doc in 2008 with ! Revealing the brain's molecular architecture, one transcript at a time - see here

    Kumoa
  20. uudelleentwiittasi
    13. jouluk.

    Important session at this morning - a discussion of the need for greater diversity in human genetics, led by . She leads off with a pretty astonishing statistic: Europeans are 80% of samples in genetic studies, vs 16% of the global population.

    Kumoa

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