CENPO

CENPO
Identifiers
Aliases	CENPO, CENP-O, ICEN-36, MCM21R, centromere protein O
External IDs	MGI: 1923800 HomoloGene: 49760 GeneCards: CENPO
Gene location (Human) Chr. Chromosome 2 (human) Band 2p23.3 Start 24,793,136 bp End 24,822,376 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12 A1.1|12 2.02 cM Start 4,196,004 bp End 4,234,294 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding Cellular component • chromosome • condensed chromosome kinetochore • cytosol • chromosome, centromeric region • kinetochore • nucleus • nucleoplasm Biological process • centromere complex assembly • CENP-A containing nucleosome assembly • sister chromatid cohesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79172	52504
Ensembl	ENSG00000138092	ENSMUSG00000020652
UniProt	Q9BU64	Q8K015
RefSeq (mRNA)	NM_001199803 NM_024322 NM_001322101	NM_134046
RefSeq (protein)	NP_001186732 NP_001309030 NP_077298	NP_598807
Location (UCSC)	Chr 2: 24.79 – 24.82 Mb	Chr 2: 4.2 – 4.23 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Centromere protein O is a protein that in humans is encoded by the CENPO gene. CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced.

External links

• Human CENPO genome location and CENPO gene details page in the UCSC Genome Browser.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334. 
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197.