CENPI

CENPI
Identifiers
Aliases	CENPI, CENP-I, FSHPRH1, LRPR1, Mis6, centromere protein I
External IDs	MGI: 2147897 HomoloGene: 4899 GeneCards: CENPI
Gene location (Human) Chr. X chromosome (human) Band Xq22.1 Start 101,098,218 bp End 101,163,681 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X E3 Start 134,308,084 bp End 134,362,639 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding Cellular component • chromosome • chromosome, centromeric region • nucleoplasm • kinetochore • nucleus • cytosol • nuclear body Biological process • sex differentiation • centromere complex assembly • CENP-A containing nucleosome assembly • sister chromatid cohesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2491	102920
Ensembl	ENSG00000102384	ENSMUSG00000031262
UniProt	Q92674	Q8K1K4
RefSeq (mRNA)	NM_006733 NM_001318521 NM_001318523	NM_145924 NM_001305631
RefSeq (protein)	NP_001305450 NP_001305452 NP_006724	NP_001292560 NP_666036
Location (UCSC)	Chr X: 101.1 – 101.16 Mb	Chr X: 134.31 – 134.36 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Centromere protein I is a protein that in humans is encoded by the CENPI gene.

The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis.

External links

• Human CENPI genome location and CENPI gene details page in the UCSC Genome Browser.

Further reading

• Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197. 
• Foltz DR, Jansen LE, Black BE, et al. (2006). "The human CENP-A centromeric nucleosome-associated complex". Nat. Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. 
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365 . PMID 16565220. 
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286 . PMID 15772651. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334. 
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. 
• Liu ST, Hittle JC, Jablonski SA, et al. (2003). "Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis". Nat. Cell Biol. 5 (4): 341–5. doi:10.1038/ncb953. PMID 12640463. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932. 
• Roberts RG, Kendall E, Vetrie D, Bobrow M (1997). "Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene". Genomics. 37 (1): 122–4. doi:10.1006/geno.1996.0528. PMID 8921378. 
• Slegtenhorst-Eegdeman KE, Post M, Baarends WM, et al. (1995). "Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein". Mol. Cell. Endocrinol. 108 (1-2): 115–24. doi:10.1016/0303-7207(94)03468-9. PMID 7758824. 
• Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. doi:10.1038/355632a0. PMID 1538749.