Contents
18 May 2016
Vol 8, Issue 339
Vol 8, Issue 339
Contents
Editorial
- Reproducibility will only come with data liberation
Data irreproducibility threatens survival of the biomedical research enterprise and the well-being of patients who require better therapies.
Research Articles
- The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia
The combination of a SMAC mimetic and a caspase inhibitor kills AML cells by inducing necroptosis.
- Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL
SMAC mimetics simultaneously activate two different cell death pathways in treatment-resistant ALL.
- Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice
Treating neutropenic fever with broad-spectrum antibiotics after allogeneic hematopoietic stem cell transplant is associated with an increase in graft-versus-host disease in mice and humans.
Editors' Choice
- The remnants of coronary heart disease
Rare genetic sequence variants reveal remnant lipoproteins as the next optimal drug target for coronary heart disease.
- Teaching an old antibody new tricks
Anti-EGFR antibodies induce immunogenic cell death in colorectal cancer.
- Double or nothing
Two-drug targeted therapy could eliminate acute myeloid leukemia, even though the individual drugs are not effective.
- Remote control of transplanted neurons in Parkinson’s disease
Regulating the activity of transplanted dopamine neurons using DREADDs enhances rescue of motor defects in a mouse model of Parkinson’s disease.
About The Cover
ONLINE COVER Antibiotics: A Double-Edged Sword. Patients receiving an allogeneic hematopoietic stem cell transplant often develop neutropenic fever, which is treated with antibiotics. Such antibiotic treatment also may inadvertently wipe out beneficial intestinal bacteria that reduce gut inflammation. Transplant patients treated with certain broad spectrum antibiotics show an increase in graft-versus-host disease in the colon (Shono et al.). Analysis of a mouse model revealed that this was due to loss of beneficial gut bacteria and overgrowth of bacterial strains that consumed the protective mucus layer of the colon rendering it more susceptible to inflammation and injury. [CREDIT: SHONO ET AL./SCIENCE TRANSLATIONAL MEDICINE]
