Contents
24 May 2016
Vol 9, Issue 429
Vol 9, Issue 429
Contents
Focus
- Suppressing the killer instinct
A study extends the list of proteins targeted by the phosphatase SHP-1 to inhibit natural killer cell activation.
- Forget about thrombosis: Platelets and Alzheimer’s disease, yet another sticky situation
Antiplatelet drugs might inhibit the nexus of platelet activation and amyloid-β aggregation in Alzheimer’s disease.
Research Articles
- Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3–induced outside-in signaling and clusterin release
Alzheimer’s disease patients may benefit from antiplatelet therapy.
- Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues
Structurally redesigned estrogens improve metabolism and vascular repair without activating cell proliferation.
- Dephosphorylation of the adaptor LAT and phospholipase C–γ by SHP-1 inhibits natural killer cell cytotoxicity
Researchers identify targets of a phosphatase that inhibits the activity of natural killer cells.
Podcast
- Science Signaling podcast for 24 May 2016: Designer estrogens
Designer estrogens can deliver the therapeutic benefits of natural estrogens with less cancer risk.
Editors' Choice
- A bad time of day to get an infection
When an animal becomes infected determines mortality.
- Choosing between interferon and death
The ubiquitylation state of the transcription factor IRF3 determines whether a virally infected cell produces interferon or dies.
- Neurotensin makes us fat
An evolutionarily conserved mechanism for stimulating the absorption of dietary fats may contribute to metabolic disease caused by modern high-fat diets.
- Exosomes deliver resistance
An lncRNA in renal cancer exosomes acts as a miRNA sponge to enable AXL- and MET-mediated resistance to the anticancer drug sunitinib.
- Papers of note in Science Translational Medicine
This week’s articles describe how SMAC mimetics kill leukemia cells and their application for patients.
- Papers of note in Science
This week’s articles highlight drug resistance in glioma, HIV-1 immunotherapy, synaptic development, the bacterial starvation response, and negative cooperativity in signaling networks.
About The Cover
Online Cover This week features a Research Article that describes the characterization of structurally redesigned estrogens that provide metabolic and vascular benefits with less risk of cancer. The image shows the structure of one of these redesigned estrogens inside the Venus symbol. [Image: chaofann, iStockphoto.com, for the Venus symbol; John A. Katzenellenbogen, Department of Chemistry, University of Illinois at Urbana-Champaign, for the drug structure]
