Contents
20 May 2016
Vol 352, Issue 6288
Vol 352, Issue 6288
Special Issue
URBAN PLANET
Introduction to special issue
- Cities are the Future
Rapid urbanization is overtaxing the planet, but it may not have to
News
- Roots of the Urban Mind
The stress of living with strangers may have spawned cherished aspects of city life.
- A Plague of Rats
As more people crowd into urban slums, the risks posed by rodent-borne diseases are on the rise.
- China Rethinks Cities
After decades of reckless growth, the country revises its vision.
- Vancouver's Green Dream
The city wants to dramatically shrink its environmental footprint, but obstacles loom.
Reviews
Perspectives
Contents
This Week in Science
Editorial
Editors' Choice
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- Tracking how humans evolve in real time
Analyses of thousands of sequenced genomes show changes in as little as a generation.
- ‘Cell painting’ highlights responses to drugs and toxins
Machine learning combined with molecular paints allows rapid screening of changes in cell shape and function.
- Researchers decry consent proposal
U.S. would require patient permission for use of anonymous tissue samples.
- A modular route to new antibiotics
Divide-and-conquer chemistry yields hundreds of candidate medicines.
- ‘Employment crisis’ for new Ph.D.s is an illusion
NSF surveys generate what seem to be conflicting data on the status of those entering the scientific job market.
- Can brain scans reveal concussion-linked disease?
By highlighting condition typically confirmed by autopsy, protein tracer could alter medical and legal landscape.
Feature
- The Truest Test
Studies that intentionally infect people with pathogens have a checkered past, but they are seeing a resurgence.
Working Life
Letters
Books et al.
- The bee whisperer
A new biography reveals how an ethologist with Jewish heritage earned the Nobel Prize for Nazi-funded research
- Philosophy for physicists
A cosmologist explores the philosophical implications of the foundational laws of nature
Policy Forum
- International migration under the microscope
Fragmented research and limited data must be addressed
- Preprints for the life sciences
The time is right for biologists to post their research findings onto preprint servers
Perspectives
- Superconductivity on the edge
Hybrid correlated systems could reveal exotic quantum transport behavior
- Methane—make it or break it
Biochemical data resolve the controversy over how methanogenic archaea produce methane
- Formin' filaments at a faster CLIP
A microtubule-tracking protein amplifies actin assembly
- Learning from nature how to land aerial robots
Smaller robots can use mechanical intelligence to simplify the task of perching on a target
Research Articles
- The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
Brain tumors can acquire resistance to therapy through changes to their microenvironment.
- The radical mechanism of biological methane synthesis by methyl-coenzyme M reductase
The final step of methanogenesis proceeds via Ni(II)-thiolate and methyl radical intermediates.
Reports
- Ubiquitous signatures of nematic quantum criticality in optimally doped Fe-based superconductors
Transport data in five families of iron-based superconductors suggest that nematicity plays a role in superconductivity.
- Rewritable artificial magnetic charge ice
Multiple long-range orders, as well as local manipulation, are demonstrated in an unconventional artificial spin ice structure.
- Supercurrent in the quantum Hall regime
Transport measurements show that quantum Hall edge states carry the supercurrent in a graphene Josephson junction.
- Quantifying the promotion of Cu catalysts by ZnO for methanol synthesis
The zinc coverage of copper nanoparticles can account for variations in methanol production from CO and H2.
- Self-assembly of noble metal monolayers on transition metal carbide nanoparticle catalysts
Transition metal carbide nanoparticles coated with noble metal monolayers resist CO poisoning during catalysis.
- Perching and takeoff of a robotic insect on overhangs using switchable electrostatic adhesion
Electrostatic adhesion enables a robotic insect to efficiently perch on and take off from natural and artificial structures.
- Control of neuronal synapse specification by a highly dedicated alternative splicing program
The RNA binding protein SLM2 directs the splice isoform identity of synaptic recognition receptors.
- Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains
A conserved peptide domain allows a cell to sense how much phosphate it has and regulate uptake of more phosphate if needed.
- Thresholds and ultrasensitivity from negative cooperativity
How binding of multiple ligands to receptors shapes dose responses.
- ppGpp couples transcription to DNA repair in E. coli
The bacterial alarmone ppGpp promotes DNA repair by shunting the transcription machinery away from DNA damage.
- HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1
Clinical and animal data confirm that HIV-1 immunotherapy boosts infected cell clearance and immune responses against the virus.
- Enhanced clearance of HIV-1–infected cells by broadly neutralizing antibodies against HIV-1 in vivo
Clinical and animal data confirm that HIV-1 immunotherapy boosts infected cell clearance and immune responses against the virus.
- Accelerated actin filament polymerization from microtubule plus ends
A mechanism for how microtubules can change actin dynamics is elucidated.
- Coregulation of tandem duplicate genes slows evolution of subfunctionalization in mammals
Duplicated genes are primarily maintained in mammalian genomes by reducing expression of one copy.
Erratum
About The Cover
COVER Massive fog rolls into Dubai, United Arab Emirates. As host to more than half of the world's population, cities have footprints that reach well beyond their municipal boundaries. Efforts are now under way to make urban areas more sustainable and efficient. The challenges and opportunities of our urban planet are highlighted in a special section beginning on page 904 and online at http://scim.ag/1Tb0WdZ.
Photo: ©Sebastian Opitz/Novarc Images
