8 April 2016
Vol. 352, No. 6282, Pages 158-a-262
Politics and budget pressure reshape science in Putin's Russia.
Asking voters to see the world from other people’s eyes can alter their attitudes for quite a long time. [Also see Perspective by Paluck]
Weaknesses in cloud parameterizations may be causing global climate models to underestimate future warming.
Prebiotic sugars, including ribose, can be made by irradiating simple ices under interstellar conditions.
Synthetic tissues with minimal cellular functionality can be externally controlled by light.
Self-propelled particles that swim in response to light can self-assemble microfluidic rectification devices under nonuniform illumination.
Researchers produce tailor-made colloidal molecules from a variety of materials using a simple sequential assembly process.
Real-time forest monitoring technologies could help track changes in tiger populations.
A conserved guanine-rich sequence could be a new target for anti–hepatitis C virus drug development.
6 April 2016
Vol. 8, No. 333, Pages 333ec56-333ra48
Postoperative liver transplant immunosuppression was personalized using a phenotypic, disease mechanism–independent and indication-agnostic approach.
The cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin facilitates atheroprotective mechanisms through oxysterol-mediated reprogramming of macrophages.
A method to culture human cortical neurons that yielded a balanced network of excitatory and inhibitory neurons revealed that these cells die in a PARP-dependent manner after neurotoxic insult.
A “datathon” model combines complementary knowledge and skills to formulate inquiries and drive research that addresses information gaps faced by clinicians.
Androgen receptor antagonists compromise the T cell response against prostate cancer, leading to early tumor relapse.
5 April 2016
Vol. 9, No. 422, Pages eg5-ra34
Regulation by Wnts and β-catenin reveals the pitfalls in canonical thinking.
HDAC inhibitors prevent pathological cardiac hypertrophy by suppressing a growth-promoting kinase.
Four IP3 molecules are needed to activate the IP3 receptor.
The requirement of four IP3 molecules to bind to activate the IP3 receptor contributes to the complex spatial organization of intracellular Ca2+ signals.
