Contents
15 April 2016
Vol 352, Issue 6283
Vol 352, Issue 6283
Contents
This Week in Science
Editorial
Editors' Choice
Products & Materials
- New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
In Brief
In Depth
- International brain projects proposed
Meeting attendees debate big science ideas, including need for global data hub.
- Arctic nations eye fishing ban
As ice recedes in central Arctic Ocean, officials meet to discuss catch moratorium until stocks can be studied.
- Dutch push for a quantum leap in open access
E.U. urged to free all papers by 2020.
- Megaproject asks: What drove the Vikings?
Researchers suggest that the nature of pre-Viking society spurred a drive for slaves.
- Obsolescence looms for balloon data
United States falls behind Europe in adopting modern data format.
- Rural China is no country for old people
Erosion of families sparks an epidemic of suicides among the elderly.
Feature
- The savior cells?
After a painstaking journey, researchers are preparing to test stem cell therapy in ailing fetuses.
- Gene therapy gets a high-stakes test
Researchers hope gene transfer can improve fetal blood supply.
Working Life
Letters
Books et al.
- Banking on balance
Getting ahead at work shouldn't have to mean falling behind at home
- Fear and loathing in the hunt for gravitational waves
One physicist hits the road to explore LIGO's history and the hard feelings that nearly derailed the entire project
Policy Forum
- Opportunities for advances in climate change economics
Target carbon's costs, policy designs, and developing countries
Perspectives
- Tackling mine wastes
Global collaboration is needed to mitigate the environmental impacts of mine wastes
- The straight dope on the scope of chemical reactions
Complementary strategies are needed for the analysis and reporting of synthetic methods
- When cells push the envelope
Nuclear integrity is temporarily compromised to accommodate cell migration
- Toward single-atom memory
Single holmium atoms can be used as a stable magnetic memory
- A scaffold immune microenvironment
Local immune cells create conditions that support tissue regeneration
Research Articles
- Architecture of the symmetric core of the nuclear pore
Reconstitution, spectroscopy, and crystallography allow the construction of a model of the human nuclear pore.
- Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA
An x-ray structure shows how a dual-specificity RNA methylase recognizes its RNA substrate.
- Flux and composition of interstellar dust at Saturn from Cassini’s Cosmic Dust Analyzer
Cassini measures the composition of interstellar dust grains as they pass through the solar system.
Review
Reports
- Magnetic remanence in single atoms
A single holmium atom on a magnesium oxide film can retain its magnetic moment up to 30 kelvin.
- Nuclear quantum effects of hydrogen bonds probed by tip-enhanced inelastic electron tunneling
Quantum effects in water hydrogen bonding are revealed with a chlorine-terminated scanning tunneling microscope tip.
- A single-atom heat engine
A calcium ion held in a tapered trap is used as the working substance of a tiny thermodynamic engine.
- Pre-transmetalation intermediates in the Suzuki-Miyaura reaction revealed: The missing link
Nuclear magnetic resonance spectroscopy captures a long-sought intermediate in a widely used C–C bond-forming reaction.
- Homogeneously dispersed multimetal oxygen-evolving catalysts
The addition of tungsten to iron cobalt oxides lowers the overpotential required for the evolution of oxygen from water.
- Climate change disables coral bleaching protection on the Great Barrier Reef
Elevated ocean temperatures are masking the sudden onsets of summer warming that used to allow corals to protect themselves.
- Belowground carbon trade among tall trees in a temperate forest
Isotopic analysis shows that up to 40% of carbon in fine roots of temperate forest trees may be derived from neighbors.
- Zika virus in the Americas: Early epidemiological and genetic findings
Virus sequencing indicates that Zika arrived in Brazil during the middle of 2013, coincident with a surge in air travelers.
- Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes
Atovaquone-resistant Plasmodium berghei do not reproduce in mosquitoes and, hence, are not transmitted.
- Nuclear envelope rupture and repair during cancer cell migration
When cells migrate, they stress their nuclear envelopes and need to guard against leakage of the nuclear contents.
- ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death
When cells migrate, they stress their nuclear envelopes and need to guard against leakage of the nuclear contents.
- Molecular architecture of the inner ring scaffold of the human nuclear pore complex
Reconstitution, spectroscopy, and crystallography allow the construction of a model of the human nuclear pore.
- Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells
Biomaterial scaffolds engage the immune system to promote tissue repair.
Erratum
About The Cover
COVER The nuclear pore complex is the sole gateway for macromolecules to enter or exit the nucleus and is one of the largest assemblies in eukaryotic cells. This illustration depicts the integrative approach used to determine structures of the individual protein components (blue), their connectivity (dashed lines), and their arrangement in the intact assembly (inside the transparent nuclear envelope). See pages 308 and 363.
Illustration: Valerie Altounian/Science; Crystallography data: André Hoelz; Electron density map: Martin Beck
