A study involving the recently approved CD19-targeting chimeric antigen receptor (CAR) T cell therapy shows that 42 percent of patients with aggressive large B-cell lymphoma remained in remission at 15 months following treatment with axi-cel (marketed as Yescarta™).
The study, named ZUMA-1, also reported measurable responses in 82 percent of patients and complete responses in 54 percent. Fifty-six percent were alive at 15 months following therapy, with some remaining cancer free two years post-treatment.
MAYWOOD, IL - Loyola University Medical Center is the only Chicago center that participated in the pivotal clinical trial of a groundbreaking cancer treatment that genetically engineers a patient's immune system to attack cancer cells.
Patrick Stiff, MD, director of Loyola's Cardinal Bernardin Cancer Center, is a co-author of the study, published December 10, 2017 in the New England Journal of Medicine.
SEATTLE - Dec. 9, 2017 - Results from a phase 2 clinical trial, presented by Seattle Children's Research Institute at the 59th American Society of Hematology (ASH) Annual Meeting, show that the drug Abatacept (Orencia) nearly eliminated life-threatening severe acute graft-versus-host disease (GvHD) in patients receiving hematopoietic stem cell transplants.
Early evidence suggests that gene therapy developed at St. Jude Children's Research Hospital will lead to broad protection for infants with the devastating immune disorder X-linked severe combined immunodeficiency disorder. Preliminary results from the ongoing, multicenter study were included in the press program here today at the 59th annual meeting of the American Society of Hematology.St.
ST. LOUIS -- In a paper published in the Nature journal Scientific Reports, Saint Louis University (SLU) researchers report that a new drug reduces fibrosis (scarring) and prevents loss of muscle function in an animal model of Duchenne muscular dystrophy (DMD), providing a promising approach in designing new medications for those suffering from DMD.
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells. To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules, particularly water, that have an affinity for the charged atoms.
The pending nuptials of Prince Harry and Meghan Markle have royal watchers brushing up on royal naming practices and asking 'what's in a name?'
A new study led by a UNLV psychology professor shows that a wife's choice of surnames may influence perceptions of her husband's personality and the distribution of power in the marriage.
In a three-part study conducted in the U.S. and the U.K., Rachael Robnett and her coauthors concluded that men whose wives retain their own surnames after marriage are seen as submissive and less powerful in the relationship.
Excitonium has a team of researchers at the University of Illinois at Urbana-Champaign... well... excited! Professor of Physics Peter Abbamonte and graduate students Anshul Kogar and Mindy Rak, with input from colleagues at Illinois, University of California, Berkeley, and University of Amsterdam, have proven the existence of this enigmatic new form of matter, which has perplexed scientists since it was first theorized almost 50 years ago.
Our physical attraction to hot bodies is real, according to UC Berkeley physicists.
To be clear, they're not talking about sexual attraction to a "hot" human body.
But the researchers have shown that a glowing object actually attracts atoms, contrary to what most people - physicists included - would guess.
As far our brain is concerned, talking to ourselves in our heads may be fundamentally the same as speaking our thoughts out loud, new research shows. The findings may have important implications for understanding why people with mental illnesses such as schizophrenia hear voices.
UNSW Sydney scientist and study first author Associate Professor Thomas Whitford says it has long been thought that these auditory-verbal hallucinations arise from abnormalities in inner speech - our silent internal dialogue.