Two young women waitressing at a greasy spoon diner strike up an unlikely friendship in the hopes of launching a successful business - if only they can raise the cash.

When their plane has trouble while on a flight to Paris, three glamorous LA women find themselves in a completely new and unexpected place. Feeling the need for a girls-only, once-in-a-lifetime trip, Melanie cashes in her airline miles to finance a trip to the city of light for herself and her two best friends, Joy and Victoria, all "of a certain age" and feeling less than desirable. They never make it to Paris, though -- when the stricken plane lands in Cleveland, the women suddenly find they're popular with the men there. Realizing that while they may be lukewarm in LA, they're hot in Cleveland, the women decide to relocate. They immediately fall in love with their rental house. It takes a little longer, however, for them to warm up to the house's longtime caretaker (Betty White).

Nobody likes real-estate agent Oren Little, and he prefers it that way. He's deliberately mean to anyone who crosses his path and wants nothing more than to sell one final house and retire. Oren's life turns upside-down when his estranged son drops off a granddaughter he didn't know existed. Oren has no idea how to take care of a child, so he pawns the girl off on his neighbor, Leah.

This talk-variety show features comic Ellen DeGeneres in the studio performing an opening monologue and interviewing guests who include celebrities, newsmakers and ordinary people with extraordinary talents. Additionally, segments include performances from top music acts, audience participation and man-on-the-street interviews. Music is a key part of the show, with an in-studio DJ -- including occasional celebrity guest DJs -- spinning tunes and DeGeneres often breaking out into dance moves during the show.

The tale of four sassy New York-based women in search of long-lasting relationships.