Shufeng Zhou
March 9, 2016
Cytochromes are proteins that catalyze electron transfer reactions of well-known metabolic pathways and are classified in various superfamilies. The CYP, or P450, superfamily accounts for 90% of the oxidative metabolism of clinical drugs. One member of this superfamily, P450 2D6 (or CYP2D6), singleh...
Philip Ng, Nicola Brunetti-Pierri
December 21, 2016
Adenoviruses are double stranded DNA viruses that have been used to study the process of DNA replication. Studies of the mode of action of adenovirally produced tumors in rodents led to the discovery of tumour supressor genes. The adenoviral vector is now the most used vector in clinical gene...
Scott D. Patterson, Byron Jones
December 20, 2016
Maintaining a practical perspective, Bioequivalence and Statistics in Clinical Pharmacology, Second Edition explores statistics used in day-to-day clinical pharmacology work. The book is a starting point for those involved in such research and covers the methods needed to design, analyze, and...
Philip Chi Lip Kwok, Hak-Kim Chan
December 20, 2016
The respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and...
Joo L. Ong, Teja Guda
December 19, 2016
Translating Biomaterials for Bone Graft: Bench-top to Clinical Applications brings together the current translational research in bone tissue engineering, from design to application – from materials, drugs and biologic delivery used for bone graft applications to pre-clinical and clinical...
Alan Moses
December 15, 2016
Molecular biologists are performing increasingly large and complicated experiments, but often have little background in data analysis. The book is devoted to teaching the statistical and computational techniques molecular biologists need to analyze their data. It explains the big-picture concepts...
Sean V. Murphy, Anthony Atala
December 13, 2016
Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The...
Michael Szycher
December 13, 2016
Commercializing a knowledge-based product or service requires a realistic, methodical approach combined with a great deal of perseverance. Commercialization Secrets for Scientists and Engineers serves as a high-level guide to answering key questions and critical issues that confront founding...
Jay Herson
December 13, 2016
Praise for the first edition: "Given the author’s years of experience as a statistician and as a founder of the first DMC in pharmaceutical industry trials, I highly recommend this book—not only for experts because of its cogent and organized presentation, but more importantly for young...
Lev S. Ruzer
December 09, 2016
A peek into the literature on the environmental health implications of the rapidly developing nanotechnology industry shows that the potential problem of exposure to airborne nanoparticles has not been adequately addressed. The health and safety of nanotechnology workers are of concern because...
Johan Gabrielsson, Daniel Weiner
December 09, 2016
Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications teaches everyday biological data analysis to the undergraduate and graduate levels. Through numerous examples and over 100 tutorials, scientists learn how to use PK/PD seamlessly in a variety of practical areas, from...
Ariel Alonso, Theophile Bigirumurame, Tomasz Burzykowski, Marc Buyse, Geert Molenberghs, Leacky Muchene, Nolen Joy Perualila, Ziv Shkedy, Wim Van der Elst
December 08, 2016
An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate...
A. Stewart Whitley, Charles Sloane, Gail Jefferson, Ken Holmes, Craig Anderson
December 06, 2016
Drawn from the bestselling Clark's Positioning in Radiography, this pocket handbook provides clear and practical advice to help radiographers in their day-to-day work. Designed for rapid reference, it covers how to position the patient and the central ray, describes the essential image...
