Daniel MacArthur

@dgmacarthur

Human genomics, rare disease, and open data. Co-director of Medical and Population Genetics at .

Boston, USA
macarthurlab.org
Iscrizione a ottobre 2008
400 foto e video Foto e video

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  1. Tweet fissato
    17 ott

    KK: The new data set is live, with an awesome new browser! Thanks to the tireless work of our engineering team, Nick Watts and , working right up to about 3 minutes before this talk (DM: can confirm.).

    5 risposte 69 Retweet 154 Mi piace
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  2. ha ritwittato
    16 ore fa

    Australia cuts research funding for universities. Funding for research and development is at its lowest point in 40 years—even as Australia forecasts a budget surplus of AU$4.1 billion in 2019-2020

    5 risposte 84 Retweet 47 Mi piace
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  3. ha ritwittato
    22 ore fa

    At 23andMe, taking calls from people who just got a life-changing surprise is so stressful that customer service reps are encouraged to go for a walk after an intense call, or crack open a bottle of wine. Great story via

    10 risposte 74 Retweet 117 Mi piace
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  4. ha ritwittato
    23 ore fa

    If you’re writing about data-sharing and your article is behind a paywall with no preprint on biorxiv, it’s perhaps time to revisit your definitions of both “data” and “sharing” 🧐

    2 risposte 88 Retweet 292 Mi piace
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  5. ha ritwittato
    18 dic

    1. What is the probability that the mutations carried by CRIPR twins Lulu and Nana are already present in the human population?

    7 risposte 42 Retweet 63 Mi piace
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  6. ha ritwittato
    15 dic
    In risposta a , e

    And without further ado, here's "A simple new approach to variable selection in regression, with application to genetic fine mapping" by

    22 Retweet 43 Mi piace
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  7. ha ritwittato
    23 ore fa

    How you make 2,300 attendees at the Broad Retreat feel like they belong

    1 risposta 4 Retweet 17 Mi piace
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  8. ha ritwittato
    17 dic

    We interviewed Mark Daly , newly appointed Director of for our website, as part of our 'Welcome to' series. Here, Prof. Daly discusses his into human , and why he chose to swap the USA for Finland:

    e
    1 risposta 40 Retweet 65 Mi piace
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  9. ha ritwittato
    18 dic

    If you're not a fan of extreme p-values in you can stop reading right here. But since I've been following the Manhattan plots generated by from the group I thought I'd "skip to the end" and look up most extreme p-value for any trait/any SNP 👇

    5 risposte 14 Retweet 52 Mi piace
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  10. ha ritwittato
    16 dic

    WRITING A PAPER IN WORD: FONT TIPS Contrary to widely held belief (among LaTeX fands), it is easy to write a nice-looking paper in Word. You just have to do three things: (1) use styles; (2) avoid hideous fonts; (3) unleash the fonts’ potential. 2\

    9 risposte 173 Retweet 553 Mi piace
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  11. ha ritwittato
    18 dic

    We are looking for two 's to join our team at in Helsinki! We offer a great opportunity to work in the forefront of the new wave of big data application for genome health. Read more and apply by 31 Jan!

    16 Retweet 10 Mi piace
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  12. ha ritwittato
    18 dic

    `the GDPR has had the unintended (but wholly predictable) consequence of consolidating market power behind the mega firms that privacy advocates hoped to take down. There is a reason that the GDPR earned its informal nickname of the "Google Data Protection Regulation"`

    Why does Google support an American data privacy law? Because it will actually help them dominate the tech market even more.
    4 risposte 115 Retweet 221 Mi piace
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  13. 17 dic

    Where to go for rare disease diagnoses after exome sequencing fails? Excellent review of the options by and :

    2 risposte 120 Retweet 189 Mi piace
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  14. ha ritwittato
    17 dic

    Check out the omission of proper negative controls.

    Check out this example blind Snapshot prediction vs. actual photo of
    2 risposte 4 Retweet 13 Mi piace
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  15. ha ritwittato
    16 dic

    Your regular friendly reminder that vaccines are completely, utterly, totally, and entirely unrelated to the development of autism (N = 1.3 million)

    17 risposte 294 Retweet 723 Mi piace
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  16. ha ritwittato
    16 dic

    A Powerful Lesson That Patients Deserve Full Control Of Their Genetic Data: 🧬A lab can refuse to share data to protect their own market position 🧬At the expense of scientific progress, and the very patients who paid them to conduct genetic testing 👉

    4 risposte 43 Retweet 71 Mi piace
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  17. ha ritwittato
    16 dic

    folks, we need to demand high standards in the current gold rush of methods devel. It's not OK for methods to be published w/ vaporware implementations. We need open src code written in open src languages w/ documentation, test data, unit tests, pkg'd, installable.

    9 risposte 39 Retweet 159 Mi piace
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  18. ha ritwittato
    16 dic

    As a Pfizer scientist I work alongside talented immigrants from all over the world. - why are you advertising on Tucker Carlson? Do you support his views on immigrants? What message are you sending to our colleagues and customers?

    Pacific Life pulls advertisements from Tucker Carlson's show after "poorer and dirtier" immigration comment
    4 risposte 17 Retweet 40 Mi piace
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  19. ha ritwittato
    16 dic

    New: "p-Hacking & False Discovery in A/B Testing" Setup: 2,101 RCTs in which businesses track effects over time. "73% of experimenters stop experiment[s] when a[n] effect reaches 90% confidence...75% of the effects are truly null."

    10 risposte 182 Retweet 497 Mi piace
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  20. ha ritwittato
    14 dic

    Reference genome falls down again; Southern blots are sometimes a geneticists best friend (especially in repeat regions). Lessons to live by, that I have encountered now in three separate phases of my career, summed up in a beautiful paper by and colleagues!

    New! & colleagues identify a GGC repeat expansion in XYLT1, demonstrating that Baratela-Scott syndrome is an autosomal recessive repeat expansion disorder
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    3 risposte 14 Retweet 42 Mi piace
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  21. ha ritwittato
    15 dic

    UCLA asked faculty to consider declining to review for Elsevier journals

    3 risposte 16 Retweet 26 Mi piace
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