Field cancerization underlies the development of many types of cancer. This Review examines the biological mechanisms that drive the evolution of cancerized fields and discusses how measuring field evolution could improve cancer risk prediction in patients with pre-malignant disease.

An analysis of biotech and pharma stock prices since 1930 reveals sharp differences in the risk-adjusted returns of the two sectors.

This protocol describes a method for cataloging genome-wide mutations that accumulated during life or culture in single adult stem cells of different human tissues, by combining whole-genome sequencing with organoid-culture technologies.

This protocol describes a microfluidics approach for culturing liquid-biopsy-derived circulating tumor cell clusters to predict a patient's response toward various therapeutic strategies.

The transcription factor Runx3 is identified as a central regulator of the development of tissue-resident memory CD8⁺ T cells, providing insights into the signals that promote T cell residency in non-lymphoid tissues and tumours.

Disulfiram is metabolized into copper–diethyldithiocarbamate, which binds to NPL4 and induces its aggregation in cells, leading to blockade of the p97–NPL4–UFD1 pathway and induction of a complex cellular phenotype that results in cell death.