Immunogenetics

Definition

Immunogenetics is the study of the genetic basis of the immune response. It includes the study of normal immunological pathways and the identification of genetic variations that result in immune defects, which may result in the identification of new therapeutic targets for immune diseases.

Latest Research and Reviews

Research | 22 September 2016
Natural genetic variation profoundly regulates gene expression in immune cells and dictates susceptibility to CNS autoimmunity
- F Bearoff
- , R del Rio
- , L K Case
- , J A Dragon
- , T Nguyen-Vu
- , C-Y Lin
- , E P Blankenhorn
- , C Teuscher
- & D N Krementsov
Genes and Immunity
Research | 14 September 2016 | open
Allergy-specific Phenome-Wide Association Study for Immunogenes in Turkish Children
- Sefayet Karaca
- , Ersoy Civelek
- , Mehmet Karaca
- , Umit M. Sahiner
- , Riza K. Ozgul
- , Can N. Kocabas
- , Renato Polimanti
- & Bülent E. Sekerel
Scientific Reports 6, 33152
Research | 31 August 2016 | open
TNF-α Promoter Polymorphisms Predict the Response to Etanercept More Powerfully than that to Infliximab/Adalimumab in Spondyloarthritis
- Jing Liu
- , Zheng Dong
- , Qi Zhu
- , Dongyi He
- , Yanyun Ma
- , Aiping Du
- , Fan He
- , Dongbao Zhao
- , Xia Xu
- , Hui Zhang
- , Li jin
- & Jiucun Wang
Scientific Reports 6, 32202
Research | 31 August 2016 | open
Influence of HLA on human partnership and sexual satisfaction
- J. Kromer
- , T. Hummel
- , D. Pietrowski
- , A. S. Giani
- , J. Sauter
- , G. Ehninger
- , A. H. Schmidt
- & I. Croy
Scientific Reports 6, 32550
Research | 22 August 2016 | open
Evolution of the immune system influences speciation rates in teleost fishes
Kjetill S. Jakobsen, Sissel Jentoft and colleagues assemble partial draft genomes and analyze sequences from 66 teleost fish species to determine major histocompatibility complex (MHC) class I and class II gene status. They find that MHC II is absent from the Gadiformes lineage, while MHC I gene expansions have occurred multiple times.
- Martin Malmstrøm
- , Michael Matschiner
- , Ole K Tørresen
- , Bastiaan Star
- , Lars G Snipen
- , Thomas F Hansen
- , Helle T Baalsrud
- , Alexander J Nederbragt
- , Reinhold Hanel
- , Walter Salzburger
- , Nils C Stenseth
- , Kjetill S Jakobsen
- & Sissel Jentoft
Nature Genetics
Research | 18 August 2016
Gene signatures associated with adaptive humoral immunity following seasonal influenza A/H1N1 vaccination
- I G Ovsyannikova
- , H M Salk
- , R B Kennedy
- , I H Haralambieva
- , M T Zimmermann
- , D E Grill
- , A L Oberg
- & G A Poland
Genes and Immunity

All Research & Reviews

News and Comment

News and Views | 29 December 2015
The requirement of iron transport for lymphocyte function
Iron is essential in multiple cellular processes and is especially critical for cellular respiration and division. A new study identified a mutation affecting the iron import receptor TfR1 as the cause of a human primary immunodeficiency, illuminating the importance of iron in immune cell function.
- Bernice Lo
Nature Genetics 48, 10–11
Editorial | 25 November 2015
Human immune system diversity and its implications in diseases
- Naoyuki Tsuchiya
- & Jun Ohashi
Journal of Human Genetics 60, 655–656
Comments and Opinion | 18 September 2015
Genomics is rapidly advancing precision medicine for immunological disorders
Advances in human genomics, when validated functionally, can lead to new insights into how the immune system works. Notably, previously unknown mechanisms revealed by genomics can lead to the development of precision medicine unanticipated on the basis of phenotype alone.
- Yu Zhang
- , Helen C Su
- & Michael J Lenardo
Nature Immunology 16, 1001–1004
News and Views | 18 September 2015
To κ⁺ B or not to κ⁺ B
Immature B lymphocytes and T lymphocytes assemble antigen receptor–encoding genes in lineage- and developmental stage–specific fashion. New findings show that pre-B cells use specialized locus-specific epigenetic mechanisms to promote recombination of the locus encoding the immunoglobulin κ-chain (Igk) and κ-chain⁺ B cell development.
- Megan R Fisher
- & Craig H Bassing
Nature Immunology 16, 1007–1009
News and Views | 18 June 2015
DNA methylation secures CD4⁺ and CD8⁺ T cell lineage borders
Dynamic control of DNA methylation in the Cd4 locus serves an important role in reinforcing the binary fate stability of helper and cytotoxic T cells.
- Yongqiang Feng
- & Alexander Y Rudensky
Nature Immunology 16, 681–683
News and Views | 09 June 2015
The heritable immune system
Big data sets are galvanizing our ability to decipher the heritability of immune responses.
- Judy Cho
Nature Biotechnology 33, 608–609

All News & Comment