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Gene: Dmel\IKKε

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General Information
Symbol
Dmel\IKKε
Species
D. melanogaster
Name
I-kappaB kinase ε
Annotation Symbol
CG2615
Feature Type
protein_coding_gene
FlyBase ID
FBgn0086657
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Snapshot
I-kappaB kinase ε (IKKε) is a serine-threonine kinase that targets the inhibitor of apoptosis Diap1 for degradation. It also negatively regulates protein kinase C and the dynein adaptor nuf. IKKε roles include specification of bristle cells, bristle cell morphogenesis, oocyte polarity, and dendrite development. [Date last reviewed: 2016-12-01]
Other Summaries
Also Known As
ik2, DmIKKε, l(2)38Ea, 38D.31
Key Links
Genomic Location
Cytogenetic map
38D4-38D5
Sequence location
2L:20,676,045..20,678,979 [+]
Recombination map
2-54
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
-
Protein Domains/Motifs
InterPro
Protein kinase domain; Protein kinase-like domain superfamily; Protein kinase, ATP binding site; Ubiquitin-like domain superfamily
Molecular Function (see GO section for details)
Experimental Evidence
protein binding; protein serine/threonine kinase activity; Rab GTPase binding
Predictions / Assertions
ATP binding; protein kinase activity; protein serine/threonine kinase activity
Summaries
Gene Group Membership
OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES -
The group of 'other conventional protein kinase domain kinases' consists of kinases with a conventional eukaryotic protein kinase domain that do not fit into any of the other major groups. This grouping is described in FBrf0201870.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\IKKε or the JBrowse view of Dmel\IKKε for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.48
Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
IKKε-RB
FBtr0081390
NM_165337
2461
720
IKKε-RC
FBtr0336824
NM_136204
2551
720
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
IKKε-PB
FBpp0080920
82.0
720
6.88
NP_724278
AAN11082
IKKε-PC
FBpp0307790
82.0
720
6.88
NP_610048
AAF53911
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

720 aa isoforms: IKKε-PB, IKKε-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\IKKε using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (23 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
protein binding
inferred from physical interaction with UniProtKB:Q9V9Y9
(assigned by UniProt )
(Otani et al., 2015, Dubin-Bar et al., 2008)
inferred from physical interaction with FLYBASE:Diap1; FB:FBgn0260635
(Kuranaga et al., 2006)
protein serine/threonine kinase activity
inferred from direct assay
(Otani et al., 2011)
Rab GTPase binding
inferred from physical interaction with FLYBASE:Rab30; FB:FBgn0031882
(Gillingham et al., 2014)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
protein kinase activity
non-traceable author statement
(Morrison et al., 2000)
protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN001491808
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (16 terms)
Terms Based on Experimental Evidence (15 terms)
CV Term
Evidence
References
actin filament bundle organization
inferred from mutant phenotype
(Otani et al., 2011)
actin filament organization
inferred from mutant phenotype
(Oshima et al., 2006)
cell death
inferred from mutant phenotype
(Kuranaga et al., 2006)
cell morphogenesis
inferred from mutant phenotype
(Oshima et al., 2006)
chaeta morphogenesis
inferred from mutant phenotype
(Bitan et al., 2010)
endocytic recycling
inferred from mutant phenotype
(Otani et al., 2011)
maintenance of epithelial integrity, open tracheal system
inferred from mutant phenotype
(Oshima et al., 2006)
microtubule bundle formation
inferred from mutant phenotype
(Bitan et al., 2010)
neuron remodeling
inferred from mutant phenotype
(Lee et al., 2009)
oocyte anterior/posterior axis specification
inferred from mutant phenotype
(Amsalem et al., 2013)
peptidyl-serine phosphorylation
inferred from direct assay
(Otani et al., 2011)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
inferred from mutant phenotype
(Kuranaga et al., 2006)
protein trans-autophosphorylation
inferred from direct assay
(Otani et al., 2011)
regulation of cytoskeleton organization
inferred from physical interaction with FLYBASE:spn-F; FB:FBgn0086362
(Dubin-Bar et al., 2008)
sensory organ precursor cell division
inferred from genetic interaction with FLYBASE:Diap1; FB:FBgn0260635
(Koto et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
peptidyl-serine phosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN001491808
(assigned by GO_Central )
(Gaudet et al., 2011)
protein phosphorylation
non-traceable author statement
(Morrison et al., 2000)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
cell tip
inferred from direct assay
(Otani et al., 2011)
cytoplasm
inferred from direct assay
(Otani et al., 2011)
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cell tip
inferred from direct assay
(Otani et al., 2011)
cytoplasm
inferred from direct assay
(Otani et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\IKKε in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Allele of IKKε
Class
Mutagen
Associated Insertion
Stocks
Known lesion
IKKε1
1
Yes
IKKε5
loss of function allele
1
Yes
IKKε3
0
Yes
IKKε2
0
Yes
IKKε4
0
Yes
IKKεGS11377
    1
    Yes
    IKKεalice
    1
    Yes
    IKKεe01853
    1
    Yes
    IKKεMB11506
      1
      Yes
      Other relevant insertions
      Transgenic Constructs ( 20 )
      For All Alleles Carried on Transgenic Constructs Show
      Transgenic constructs containing/affecting coding region of IKKε
      Allele of IKKε
      Mutagen
      Associated Transgenic Construct
      Stocks
      IKKεGD5424
      3
      IKKεDN.Scer\UAS
      0
      IKKεdsRNA.Scer\UAS
      0
      IKKεG250D.Scer\UAS.T:Hsap\MYC
      0
      IKKεScer\UAS.T:Hsap\MYC
      0
      IKKεGL00160
      1
      IKKεNIG.2615R
      0
      IKKεScer\UAS.cKa
      0
      IKKεUASp.EGFP
      0
      IKKεHMS01188
      1
      IKKεKK102408
      1
      IKKεD160N.Scer\UAS.T:Hsap\MYC
      0
      IKKεG19R.Scer\UAS.T:Hsap\MYC
      0
      IKKεScer\UAS.cOa
      0
      IKKεΔUbl.Scer\UAS.T:Hsap\MYC
      0
      IKKεUAS.ORF.Tag:HA
      1
      IKKεS175A.UAS.Tag:MYC
      0
      IKKεScer\UAS.T:Ivir\HA1
      0
      IKKεUAS.EGFP
      0
      IKKεUAS.ORF
      0
      Transgenic constructs containing regulatory region of IKKε
      Deletions and Duplications ( 14 )
      Summary of Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Lethality
      Allele
      lethal | recessive
      lethal - all die before end of first instar larval stage | dorsal/ventral axis specification defective | maternal effect | recessive
      lethal - all die before end of first instar larval stage | recessive
      viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
      viable, with Scer\GAL4Mef2.PR
      viable, with Scer\GAL4pnr-MD237
      viable, with Scer\GAL4tin.CΔ4
      Sterility
      Allele
      female semi-sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
      Other Phenotypes
      Allele
      cell shape defective, with Scer\GAL4Act5C.PI
      flight defective, with Scer\GAL4Mef2.PR
      increased cell death, with Scer\GAL4Act5C.PHb
      increased cell death, with Scer\GAL4GMR.PF
      increased cell death | larval stage, with Scer\GAL4ppk.PG
      increased cell death | larval stage | heat sensitive, with Scer\GAL4ppk.PG, Scer\GAL80ts.αTub84B
      neuroanatomy defective, with Scer\GAL4ppk.1.9
      neuroanatomy defective | larval stage, with Scer\GAL4ppk.PG
      neuroanatomy defective | larval stage | heat sensitive, with Scer\GAL4ppk.PG, Scer\GAL80ts.αTub84B
      neuroanatomy defective | pupal stage, with Scer\GAL4ppk.PG
      neuroanatomy defective | pupal stage | somatic clone
      some die during first instar larval stage | maternal effect | recessive
      some die during first instar larval stage | recessive
      visible, with Scer\GAL4neur-P72
      visible, with Scer\GAL4pnr-MD237
      visible | adult stage
      visible | adult stage, with Scer\GAL4sca.PU
      Phenotype manifest in
      Allele
      actin filament bundle, with Scer\GAL4ap-md544
      arista lateral, with Scer\GAL4ap-md544
      border follicle cell, with Scer\GAL4slbo.2.6
      chaeta, with Scer\GAL4ap-md544
      chaeta, with Scer\GAL4neur-P72
      cuticle | germline clone
      dendrite, with Scer\GAL4ppk.1.9
      dendrite & dorsal multidendritic neuron ddaC | larval stage | conditional - heat sensitive, with Scer\GAL4ppk.PG, Scer\GAL80ts.αTub84B
      dendrite & dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4ppk.PG
      dendrite & dorsal multidendritic neuron ddaC | pupal stage | somatic clone
      dendrite | larval stage, with Scer\GAL4ppk.PG
      dendrite | pupal stage, with Scer\GAL4ppk.PG
      dorsal appendage | germline clone
      dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9
      egg chamber & microtubule | germ-line clone
      embryo | maternal effect, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
      embryonic/first instar larval cuticle | germline clone
      embryonic abdomen | ectopic | germline clone
      embryonic head | germline clone
      embryonic tracheole, with Scer\GAL4btl.PS
      eye, with Scer\GAL4GMR.PF
      humeral bristle
      interommatidial bristle
      macrochaeta, with Scer\GAL4ap-md544
      macrochaeta, with Scer\GAL4neur-GAL4-A101
      macrochaeta, with Scer\GAL4sca-P309
      macrochaeta | supernumerary, with Scer\GAL4sca-P309
      mesothoracic bristle
      mesothoracic bristle, with Scer\GAL4sca.PU
      microtubule, with Scer\GAL4neur-GAL4-A101
      microtubule & dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4ppk.PG
      rhabdomere R7, with Scer\GAL4Rh3.PP
      S2 cell-line & filamentous actin, with Scer\GAL4Act5C.PI
      scutellar bristle, with Scer\GAL4neur-GAL4-A101
      scutellar bristle, with Scer\GAL4sca.PU
      sensory mother cell | supernumerary, with Scer\GAL4sca-P309
      terminal tracheal cell
      terminal tracheal cell, with Scer\GAL4btl.PS
      terminal tracheal cell & filamentous actin
      terminal tracheal cell & filopodium
      trichogen cell, with Scer\GAL4pnr-MD237
      Orthologs
      Downloads
      Download All DIOPT Orthologs
      Download All OrthoDB Orthologs
      Human Orthologs (via DIOPT v7.1)
      Homo sapiens (Human) (4)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Source
      Compara
      eggNOG
      Hieranoid
      Homologene
      Inparanoid
      Isobase
      OMA
      OrthoDB
      OrthoFinder
      OrthoInspector
      orthoMCL
      Panther
      Phylome
      RoundUp
      TreeFam
      ZFIN
      Alignment
      Complementation?
      Transgene?
      Hsap\TBK1
      12 of 15
      Yes
      Yes
       
      Hsap\IKBKE
      9 of 15
      No
      Yes
      Hsap\CHUK
      2 of 15
      No
      No
      Hsap\IKBKB
      2 of 15
      No
      No
      Model Organism Orthologs (via DIOPT v7.1)
      Mus musculus (laboratory mouse) (4)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Source
      Compara
      eggNOG
      Hieranoid
      Homologene
      Inparanoid
      Isobase
      OMA
      OrthoDB
      OrthoFinder
      OrthoInspector
      orthoMCL
      Panther
      Phylome
      RoundUp
      TreeFam
      ZFIN
      Alignment
      Complementation?
      Transgene?
      Mmus\Tbk1
      12 of 15
      Yes
      Yes
      Mmus\Ikbke
      9 of 15
      No
      Yes
      Mmus\Chuk
      2 of 15
      No
      No
      Mmus\Ikbkb
      2 of 15
      No
      No
      Rattus norvegicus (Norway rat) (4)
      Rnor\Tbk1
      10 of 13
      Yes
      Yes
      Rnor\Ikbke
      9 of 13
      No
      Yes
      Rnor\Chuk
      2 of 13
      No
      No
      Rnor\Ikbkb
      2 of 13
      No
      No
      Xenopus tropicalis (Western clawed frog) (4)
      Xtro\tbk1
      6 of 12
      Yes
      Yes
      Xtro\chuk
      2 of 12
      No
      No
      Xtro\ikbkb
      2 of 12
      No
      No
      Xtro\ikbke
      1 of 12
      No
      Yes
      Danio rerio (Zebrafish) (4)
      Drer\tbk1
      10 of 15
      Yes
      Yes
      Drer\ikbke
      9 of 15
      No
      Yes
      Drer\chuk
      2 of 15
      No
      No
      Drer\ikbkb
      2 of 15
      No
      No
      Caenorhabditis elegans (Nematode, roundworm) (2)
      Cele\Y39G8B.5
      4 of 15
      Yes
      Yes
      Cele\ikke-1
      3 of 15
      No
      Yes
      Arabidopsis thaliana (thale-cress) (1)
      Atha\CIPK12
      1 of 9
      Yes
      Yes
      Saccharomyces cerevisiae (Brewer's yeast) (1)
      Scer\ATG1
      1 of 15
      Yes
      No
      Schizosaccharomyces pombe (Fission yeast) (0)
      No orthologs reported.
      Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919035X )
      Organism
      Common Name
      Gene
      AAA Syntenic Ortholog
      Multiple Dmel Genes in this Orthologous Group
      Drosophila melanogaster
      fruit fly
      Dmel\IKKε
      Drosophila suzukii
      Spotted wing Drosophila
      Dsuz\DS10_00000826
      Drosophila simulans
      Dsim\GD24274
      Drosophila sechellia
      Dsec\GM23363
      Drosophila erecta
      Dere\GG21246
      Drosophila yakuba
      Dyak\GE12340
      Drosophila ananassae
      Dana\GF15349
      Drosophila pseudoobscura pseudoobscura
      Dpse\GA15402
      Drosophila persimilis
      Dper\GL18514
      Drosophila willistoni
      Dwil\GK15052
      Drosophila virilis
      Dvir\GJ22988
      Drosophila mojavensis
      Dmoj\GI18250
      Drosophila grimshawi
      Dgri\GH10877
      Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501U0 )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Musca domestica
      House fly
      Mdoa\17015164
      Glossina morsitans
      Tsetse fly
      Gmor\GMOY003071
      Lucilia cuprina
      Australian sheep blowfly
      Lcup\FF38_07607
      Aedes aegypti
      Yellow fever mosquito
      Aaeg\AAEL005359
      Anopheles darlingi
      American malaria mosquito
      Adar\ADAC010256
      Anopheles gambiae
      Malaria mosquito
      Agam\AGAP009565
      Culex quinquefasciatus
      Southern house mosquito
      Cqui\CPIJ006852
      Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01FE )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Bombyx mori
      Silkmoth
      Bmor\BGIBMGA000198
      Danaus plexippus
      Monarch butterfly
      Dple\DPOGS209901-PA
      Heliconius melpomene
      Postman butterfly
      Hmel\HMEL010487
      Apis florea
      Little honeybee
      Aflo\2224274148
      Apis mellifera
      Western honey bee
      Amel\ik2
      Bombus impatiens
      Common eastern bumble bee
      Bimp\BIMP19803
      Bombus terrestris
      Buff-tailed bumblebee
      Bter\15209810
      Linepithema humile
      Argentine ant
      Lhum\LH23091
      Megachile rotundata
      Alfalfa leafcutting bee
      Mrot\MROTU:000d8b
      Nasonia vitripennis
      Parasitic wasp
      Nvit\Nasvi2EG009557
      Dendroctonus ponderosae
      Mountain pine beetle
      Dpod\YQE_08799
      Dendroctonus ponderosae
      Mountain pine beetle
      Dpod\YQE_12483
      Tribolium castaneum
      Red flour beetle
      Tcas\ik2
      Tribolium castaneum
      Red flour beetle
      Tcas\TC009797
      Pediculus humanus
      Human body louse
      Phum\PHUM387680
      Cimex lectularius
      Bed bug
      Clec\CLEC005856
      Acyrthosiphon pisum
      Pea aphid
      Apim\ACYPI008988
      Zootermopsis nevadensis
      Nevada dampwood termite
      Znev\Znev_09491
      Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01SN )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Strigamia maritima
      European centipede
      Smar\SMAR011778
      Ixodes scapularis
      Black-legged tick
      Isca\ISCW020049
      Stegodyphus mimosarum
      African social velvet spider
      Smim\KFM71066.1
      Tetranychus urticae
      Two-spotted spider mite
      Turt\tetur26g02580
      Daphnia pulex
      Water flea
      Dpux\DAPPUDRAFT_300170
      Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0354 )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Strongylocentrotus purpuratus
      Purple sea urchin
      Spur\Sp-Tbk1
      Strongylocentrotus purpuratus
      Purple sea urchin
      Spur\Sp-Tbk1_1
      Strongylocentrotus purpuratus
      Purple sea urchin
      Spur\Sp-Ikke
      Strongylocentrotus purpuratus
      Purple sea urchin
      Spur\Sp-Ikke_1
      Ciona intestinalis
      Vase tunicate
      Cint\ENSCING00000005640
      Gallus gallus
      Domestic chicken
      Ggal\TBK1
      Gallus gallus
      Domestic chicken
      Ggal\IKBKE
      Human Disease Model Data
      FlyBase Human Disease Model Reports
      Alleles Reported to Model Human Disease (Disease Ontology)
      Download
      Models ( 0 )
      Allele
      Disease
      Evidence
      References
      Interactions ( 0 )
      Allele
      Disease
      Interaction
      References
      Comments ( 0 )
       
      Human Orthologs (via DIOPT v7.1)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      Complementation?
      Transgene?
      TBK1; TANK binding kinase 1
      12 of 15
      604834
       
      IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon
      9 of 15
      605048
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        IKKε
        suppressible
        ctp
        (Otani et al., 2011)
        IKKε
        suppressible
        Dhc64C
        (Otani et al., 2011)
        IKKε
        suppressible
        Diap1
        (Otani et al., 2011, Oshima et al., 2006)
        IKKε
        enhanceable
        Diap1
        (Koto et al., 2009, Oshima et al., 2006)
        IKKε
        suppressible
        Dronc
        (Kuranaga et al., 2006)
        IKKε
        enhanceable
        Dronc
        (Koto et al., 2009)
        IKKε
        enhanceable
        f
        (Otani et al., 2011)
        IKKε
        suppressible
        nuf
        (Otani et al., 2011)
        IKKε
        enhanceable
        Rab11
        (Otani et al., 2011)
        IKKε
        suppressible
        spn-F
        (Lin et al., 2015)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        par-1
        enhanceable
        IKKε
        (Herzmann et al., 2017)
        rpr
        suppressible
        IKKε
        (Kuranaga et al., 2006)
        spn-F
        suppressible
        IKKε
        (Otani et al., 2015, Amsalem et al., 2013)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Pathways
        Gene Group - Pathway Membership (FlyBase)
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-54
        Cytogenetic map
        38D4-38D5
        Sequence location
        2L:20,676,045..20,678,979 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        38D4-38D5
        Limits computationally determined from genome sequence between P{lacW}k02501&P{lacW}k14810 and P{PZ}Hr3802306&P{PZ}dia1
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        38E1-38E5
        (Inohara, 1999.10.22)
        Experimentally Determined Recombination Data
        Location
        2-54
        (FlyBase, 2016)
        2-54.1
        (Comeron et al., 2012)
        2-
        (Kozlova et al., 1998)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (13)
        Genomic Clones (21)
        cDNA Clones (26)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        polyclonal
        (Otani et al., 2011)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for identity of: ik2 CG2615
        (Adams, 1999.11)
        Source for identity of: IKKε ik2
        (FlyBase, 2009-)
        Source for database merge of
        Source for merge of: ik2 l(2)38Ea
        (Shapiro and Anderson, 2006)
        Additional comments
        Renamed from 'ik2' to 'IKKε' to be more informative/consistent, and to represent usage in FBrf0193419, FBrf0194448 and FBrf0212985 etc.
        (FlyBase, 2009-)
        Other Comments
        ik2 protein is locally activated (by phosphorylation at residue Ser175) at the tip of growing mechanosensory bristles and controls the rapid shuttling of recycling endosomes. ik2 is also involved in actin bundle organisation. These two processes (recycling endosome dynamics and actin bundle organisation) appear to be independently regulated by ik2.
        (Otani et al., 2011)
        Mutations in ik2 affect polarized bristle microtubule formation.
        (Bitan et al., 2010)
        ik2 is required for dendritic severing during dendrite pruning of ddaC neurons in the pupa.
        (Lee et al., 2009)
        ik2 acts upstream of the Tl-dl pathway during oogenesis.
        (Shapiro and Anderson, 2006)
        Both the actin cytoskeleton and the anchoring of microtubule minus-ends are disrupted in ik2 mutants.
        (Shapiro and Anderson, 2006)
        When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a whole range of mitotic abnormalities and spindle abnormalities are seen.
        (Bettencourt-Dias et al., 2004)
        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
        (Kiger et al., 2003)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 47 )
        Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        InterPro - A database of protein families, domains and functional sites
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMine - An integrated database for Drosophila genomics
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Synonyms and Secondary IDs (26)
        Reported As
        Symbol Synonym
        38D.31
        (Butler, 2001, Butler et al., 2001, McGill Drosophila Genome Project, 2001.9.25)
        APTX7
        (Kuranaga et al., 2006)
        CG2615
        (Hosono et al., 2015, Schertel et al., 2013, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Sinka et al., 2008, Kuranaga et al., 2006, Oshima et al., 2006, Kanuka et al., 2005, Morrison et al., 2000)
        DIK2
        (Morrison et al., 2000)
        Dik2
        DmIKKε
        (Yu and Pan, 2018, Nakajima and Kuranaga, 2017, Orme et al., 2016, Kuranaga, 2011, Miura, 2011, Koto et al., 2009, Bergmann, 2006, Kuranaga et al., 2006, Montell, 2006, Liao et al., 2002, Wasserman, 2000)
        DmIKKε/dIK2
        (Silverman and Maniatis, 2001)
        Dmik2
        (Lemaitre, 2000.12.20)
        IK2
        (Lazzaro et al., 2004, Sun et al., 2002, Sun et al., 2002)
        IKK
        (Silverman et al., 2008)
        IKKepsilon
        (Zhang et al., 2018)
        IKKε
        (Otani et al., 2015, Otani et al., 2011, Oshima, 2006, Oshima et al., 2006)
        Ik2
        (Amsalem et al., 2013, Bond and Foley, 2009, Caussinus et al., 2008, Bergmann, 2006, Wasserman, 2000)
        Ik2/DmIKK
        (Kuranaga et al., 2006)
        dIKK
        (Mushegian and Medzhitov, 2001)
        dIKKε
        (Goto et al., 2018)
        dik2
        (Inohara, 1999.10.22)
        ik2
        (Herzmann et al., 2017, Lin et al., 2015, Sopko et al., 2014, Amsalem et al., 2013, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Dubin-Bar et al., 2011, Tao and Rolls, 2011, Bitan et al., 2010, Lee et al., 2009, Dubin-Bar et al., 2008, Somma et al., 2008, Dubin-Bar and Abdu, 2007, Matthews, 2007.10.18, Lazzaro et al., 2006, Oshima et al., 2006, Shapiro and Anderson, 2006, Kanuka et al., 2005)
        ikkε
        (Otani et al., 2015)
        l(2)38Ea
        (Kozlova et al., 2009, Kuranaga et al., 2006, Oshima, 2006)
        Name Synonyms
        I-kappaB kinase ε
        IKK-related kinase
        (Dubin-Bar et al., 2008)
        Ik2
        (Gillingham et al., 2014)
        IkappaB kinase-like 2
        (Caussinus et al., 2008)
        IκB kinase-like 2
        (Shapiro and Anderson, 2006)
        apoptoxin 7
        (Kuranaga et al., 2006)
        ik2
        lethal (2) 38Ea
        Secondary FlyBase IDs
        • FBgn0025164
        • FBgn0028633
        • FBgn0043071
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (97)