Hidden Figures: the movie

Posted on behalf of Elizabeth Gibney

Taraji P. Henson as NASA ‘human computer’ Katherine Johnson. Over the course of her career, Johnson calculated the trajectories and launch windows for flights including the early missions of John Glenn and the Apollo 11 flight to the Moon, and did early work on the Mars mission.

Courtesy of Twentieth Century Fox

High-profile protests dominated the media during the civil rights era in 1960s America. At NASA, a quieter struggle was already underway. From the 1940s, African-American women had been chipping away at perceptions and making incursions into the early space programme — that otherwise very white, male world.

The stories of three of these scientific whizzes – Dorothy VaughanKatherine Johnson and Mary Jackson – are now told in Hidden Figures, a film directed by Theodore Melfi and based on a book of the same name by Margot Lee Shetterly (reviewed here for Nature by Alexandra Witze).

This sharp, witty triple biopic captures the focused frenzy of the United States’ space race with the Soviet Union, when NASA was trying to figure out how to achieve the remarkable feat of launching a man into orbit atop a rocket and returning him safely. That all-out effort meant opening the doors to the best people — which in turn created an opportunity for these pioneering African-American women to take on roles previously barred to them.

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The Langley band of ‘human computers’ led by Dorothy Vaughn (played by Octavia Spencer).

Courtesy of Twentieth Century Fox

The movie recreates NASA’s Langley Research Center in Virginia, a state that in the early 1960s remained segregated. Vaughan, Johnson and Jackson are among Langley’s human “computers”: women hired to do the mathematics behind space flight, in the days just before the room-sized first IBM machine did it for them. This smart, passionate band, who made up the West Computing group, spend their days calculating launch and landing trajectories and air flow around capsules, armed only with pencils and reams of paper.

The trio were truly extraordinary. Vaughan, played by Academy Award-winner Octavia Spencer, is the matriarch. Although head of the computing group, she is not initially recognised as such for racist reasons. The film shows her initiative over the years in becoming an expert programmer of computing machines as the march of technology sees electronic counterparts to human computers emerge. Meanwhile Jackson, played with spirit by singer Janelle Monáe, wants to be an engineer. She struggles to reach ever-moving goalposts, including segregation laws that prevent her from attending the only school where she could get the necessary qualifications. Monáe’s vivacity earns her most of the film’s best lines.

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Octavia Spencer as ‘human computer’ supervisor Dorothy Vaughan.

Courtesy of Twentieth Century Fox

The main focus in on Johnson, perhaps the most remarkable of the three. Her work stands at the very heart of US success in space. The film opens with her as a child prodigy, then zips past degrees in mathematics and French, and graduate school at West Virginia University — where she was one of the first black students to attend. At NASA she was soon picked to join the Space Task Force, who needed her talents in calculating the geometries of parabolic and, later, orbital flight. So indispensable was she that astronaut John Glenn asked for her to personally check the calculations of his trajectory by hand, ahead of the first US orbital flight in 1962.

Johnson is portrayed by Taraji P. Henson as quiet, tenacious and warm-hearted. The character could not be more different from Henson’s role as gangster Cookie Lyon in the music-industry television drama Empire. Johnson is a whizz with the chalk, often seen up a ladder scrawling calculations on a giant blackboard. She carves out her own position in the team, and in colourful outfits and heels offers a human face as often the only woman in a sea of white-shirted, pencil-tied men. (Among many excellent supporting actors, such as The Big Bang Theory’s Jim Parsons, Kevin Costner as a fictional amalgamation of several real NASA leaders deserves special mention. Gum-chewing and hard-nosed, he insists on referring to his team as “gentlemen” despite Johnson’s presence; but his desire to reach the heavens is what gives her her chance.)

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Janelle Monáe as Mary Jackson, who later became a NASA engineer.

Courtesy of Twentieth Century Fox

Hidden Figures succeeds in revealing the institutionalised racism faced by the women and their families. Bathrooms, drinking fountains, schools, libraries — all were segregated. One of the best exchanges is between Vaughan and computing pool supervisor Vivian Mitchell (Kirsten Dunst), who insists, “I have nothing against y’all”. To this, Vaughan kindly replies: “I know you probably believe that.” And the women’s status as invisible engines driving the space programme contrasts clearly with the pomp surrounding the astronauts, who as the faces of NASA seem constantly showered with red, white and blue confetti.

Yet the upbeat film can sometimes come across as sanitised. There are no real baddies: even the racist characters, flawed with conscious or unconscious bias, seem ultimately good. A touch more anger wouldn’t have detracted from the enjoyable feel-goodness, epitomised by a bouncing soundtrack  by co-producer Pharrell Williams (composer of mega-hit Happy).

On another level, this may be an effort to avoid the film being solely about race. Rather, it is about women and their love of science. Vaughan, Johnson and Jackson had families to support and could not risk everything in the political fight for equality. In chasing their passions, these three chose to foment change from the inside. Hidden Figures fleshes its characters out into real human beings, and tells their cracking story with grace.

Elizabeth Gibney is a reporter on physics for Nature based in London. She tweets at @LizzieGibney. Hidden Figures’ US premiere is 25 December 2016; general release is on 6 January. The film’s UK premiere is 10 February 2017; general release is on 17 February.  

 

For Nature’s full coverage of science in culture, visit www.nature.com/news/booksandarts.

Nature Chemistry’s Altmetric top 10 for 2016

Altmetric recently posted its usual top-100 list and, as usual, there was very little chemistry to be found on it (maybe the reasons behind that should be the subject of a long soul-searching post or editorial, but that’s for another day year). After I had a little moan on Twitter, @nunobimbo asked if we’d post Nature Chemistry‘s top 10 as we did back in 2013. So, here goes… (note: I only considered Articles that appeared in 2016 print issues and these numbers are correct as of Dec 14th, 2016).

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1. Fast and selective ring-opening polymerizations by alkoxides and thioureas
Xiangyi Zhang, Gavin O. Jones, James L. Hedrick & Robert M. Waymouth

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(Altmetric score for this list = 694)
(Page views as of the date of this list = 7,746)

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2. Imaging single-molecule reaction intermediates stabilized by surface dissipation and entropy
Alexander Riss, Alejandro Pérez Paz, Sebastian Wickenburg, Hsin-Zon Tsai, Dimas G. De Oteyza, Aaron J. Bradley, Miguel M. Ugeda, Patrick Gorman, Han Sae Jung, Michael F. Crommie, Angel Rubio & Felix R. Fischer

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(Altmetric score for this list = 447)
(Page views as of the date of this list = 7,553)

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3. Molecular rectifier composed of DNA with high rectification ratio enabled by intercalation
Cunlan Guo, Kun Wang, Elinor Zerah-Harush, Joseph Hamill, Bin Wang, Yonatan Dubi & Bingqian Xu

nchem.2480-TOC
(Altmetric score for this list = 343)
(Page views as of the date of this list = 4,136)

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4. Self-assembling biomolecular catalysts for hydrogen production
Paul C. Jordan, Dustin P. Patterson, Kendall N. Saboda, Ethan J. Edwards, Heini M. Miettinen, Gautam Basu, Megan C. Thielges & Trevor Douglas

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(Altmetric score for this list = 331)
(Page views as of the date of this list = 8,092)

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5. A highly stretchable autonomous self-healing elastomer
Cheng-Hui Li, Chao Wang, Christoph Keplinger, Jing-Lin Zuo, Lihua Jin, Yang Sun, Peng Zheng, Yi Cao, Franziska Lissel, Christian Linder, Xiao-Zeng You & Zhenan Bao

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(Altmetric score for this list = 285)
(Page views as of the date of this list = 27,427)

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6. The structural and chemical origin of the oxygen redox activity in layered and cation-disordered Li-excess cathode materials
Dong-Hwa Seo, Jinhyuk Lee, Alexander Urban, Rahul Malik, ShinYoung Kang & Gerbrand Ceder

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(Altmetric score for this list = 167)
(Page views as of the date of this list = 5,108)

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7. Neutral zero-valent s-block complexes with strong multiple bonding
Merle Arrowsmith, Holger Braunschweig, Mehmet Ali Celik, Theresa Dellermann, Rian D. Dewhurst, William C. Ewing, Kai Hammond, Thomas Kramer, Ivo Krummenacher, Jan Mies, Krzysztof Radacki & Julia K. Schuster

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(Altmetric score for this list = 157)
(Page views as of the date of this list = 3,610)

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8. A supramolecular ruthenium macrocycle with high catalytic activity for water oxidation that mechanistically mimics photosystem II
Marcus Schulze, Valentin Kunz, Peter D. Frischmann & Frank Würthner

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(Altmetric score for this list = 156)
(Page views as of the date of this list = 6,202)

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9. Force-induced tautomerization in a single molecule
Janina N. Ladenthin, Thomas Frederiksen, Mats Persson, John C. Sharp, Sylwester Gawinkowski, Jacek Waluk & Takashi Kumagai

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(Altmetric score for this list = 145)
(Page views as of the date of this list = 4,035)

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10. Diindeno-fusion of an anthracene as a design strategy for stable organic biradicals
Gabriel E. Rudebusch, José L. Zafra, Kjell Jorner, Kotaro Fukuda, Jonathan L. Marshall, Iratxe Arrechea-Marcos, Guzmán L. Espejo, Rocío Ponce Ortiz, Carlos J. Gómez-García, Lev N. Zakharov, Masayoshi Nakano, Henrik Ottosson, Juan Casado & Michael M. Haley

nchem.2518-TOC
(Altmetric score for this list = 144)
(Page views as of the date of this list = 5,248)

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(Note: it seems as though the page views on the metrics pages only go up to Dec 2… we’ll maybe have someone look into that…)

The story behind the story: Breathe the last bits of air

This week, Futures welcomes Emily McCosh with her story Breathe the last bits of air. Emily is based in southern California, and you can keep up with her work at her website or by following her on Twitter. Here she talks bout her inspiration for her latest tale — as ever, it pays to read the story first.

Writing Breathe the last bits of air

I have a short attention span for plays, where everything is long-winded, and described through dialogue — irony, I know — but there has been one that I thoroughly enjoyed. My English professor assigned Samuel Beckett, and his play Endgame, a weird and dystopian piece of work that was so far from Shakespeare and Sophocles that I couldn’t help but be pulled in by the sheer difference. The play was absolutely absurd, following the rambling, snarky sentences of two of (what seemed to be) the last people on Earth.

The style of their speech was bizarre to say the least, so of course, the assignment after reading the play was to write a few sentences emulating the dialogue of Endgame’s main characters. I wrote a full version of this story instead, wondering what it would be like to experiment with a full plot. Months later, I realized it could be a true story worth reading, and with a few tweaks and details added, it became the piece it is now.

It’s certainly one of the strangest things I’ve written. But I hope readers find just as much beauty in the strangeness as I did when reading Endgame.

Looking back: The mystery of Knut, the famous polar bear

Guest blog by Alex Greenwood, Leibniz Institute for Zoo and Wildlife Research (IZW), Germany

Knut the polar bear

Berlin Zoological Garden

Earlier in 2016 Scientific Reports celebrated its fifth anniversary. You can view our interactive infographic and blogs marking this occasion here.

As this fifth anniversary year draws to a close, we’ve got back in touch with authors from two popular papers from recent years.

Now that some time has passed, we wanted to know about their experience publishing with the journal, what impact they felt their research has had and what’s surprised them.

First up, here is an interview with Alex Greenwood, an author of the study in Scientific Reports that suggested Knut, the famous hand-reared polar bear from the Berlin Zoological Gardens, suffered from anti-NMDA receptor (NMDAR) encephalitis. The study “Anti-NMDA Receptor Encephalitis in the Polar Bear (Ursus maritimus) Knut” is available here.

We spoke to Professor Greenwood about the research.

Alex Greenwood

Could you give a brief overview of your paper in Scientific Reports?

Our study in Scientific Reports was the culmination of our efforts to determine what caused the death of Knut, the world famous polar bear. A necropsy performed at the Leibniz Institute for Zoo and Wildlife Research (IZW) determined that Knut had inflammation of the brain (encephalitis) and suggested the cause was an infectious agent. However, intensive, cutting-edge pathogen diagnostics immediately after necropsy did not identify any causal pathogen. The negative results required completely new thinking and approaches; among the candidates was an autoimmune disease.

Similar to Knut’s case, many human medical cases went undiagnosed for decades because a causative pathogen could not be linked to the symptoms of encephalitis. In 2007 it was revealed that many of these patients suffered from an autoimmune disease (where the patient’s antibodies attack their own brain as foreign material). The most common among these diseases is anti-NMDA disease — where the patient’s antibodies attack the N-methyl-D aspartate receptor in the brain, leading to severe inflammation. The team of Dr. Harald Prüß at Charité/German Center for Neurodegenerative Diseases (DZNE) Berlin, who are experts on these diseases, reasoned that this could potentially explain Knut’s case. After extensive testing, the teams at the IZW and Charité determined that this in fact is what explained Knut’s encephalitis.

What sort of impact have your findings had?

Anti-NMDA disease is now more broadly recognized among the public because of its association with Knut. This will hopefully lead to improvements in diagnosis of this and related diseases, particularly because in humans the presentation of the disease can be quite variable.  Zoo and wildlife veterinarians have realized that not all diseases, even those where a pathogen is suspected, will necessarily be the result of infectious diseases and that management practices may have to take this into consideration. For example, the counterintuitive management strategy in such an encephalitis case would be to suppress the immune system — not a therapeutic intervention one would necessarily consider in the case of a pathogen caused disease. At the very least, it is quite likely that new cases in more species will be identified, expanding this disease’s occurrence to mammals in general. Others have already seen rarer neuronal receptor diseases in domestic cats. These diseases are unlikely to be restricted to cats and polar bears.

Was there anything surprising about this research?

Upon taking on Knut’s case, the flood of expert opinions, all supporting an infectious pathogen as the cause of Knut’s symptoms, was deafening. It was interesting to see how this guided so many of the contributions from collaborators and spectators. In many ways this narrowed the number of avenues initially investigated. We tried to keep an open mind but some of the ideas we had — including an aberrant immune reaction — were beyond what we thought is amenable to study in wildlife diseases, given that so much less is known about wildlife biology than human or laboratory animal biology.  Many of the techniques we considered would have likely yielded data difficult to interpret, without the fundamental knowledge of, for example, which proteins are expressed where in a polar bear.

Their sharp eyes and the constructive collaboration with Dr. Harald Prüß and his team made it possible to consider the improbable — and demonstrate that the improbable was in fact the answer. The ability to transfer the techniques from human medicine to a polar bear case was both unusual and extremely fortunate.

Was there a particular reason you chose to publish in Scientific Reports?

The study performed, in essence, represents a case report. Scientific Reports recognized that the findings in this case go well beyond Knut as an individual and allowed it to be peer reviewed. The identification of this disorder, which before Knut was only recognized as a human disease, must now be considered a disease of mammals with consequences for diagnosis and management in veterinary medicine in particular. Because Scientific Reports is open access this means anyone who is confronted with a similar case and suspects an autoimmune disease can refer to our study and our methods with no barriers to access. This was an important element in our consideration of where to submit the manuscript.

Professor Alex D. Greenwood is the Head of the Department of Wildlife Diseases at the Leibniz Institute for Zoo and Wildlife Research (IZW) and Professor of Wildlife Diseases in the Department of Veterinary Medicine of the Freie Universität Berlin, both institutions in Berlin, Germany. His work has focused on evolutionary virology, primarily on retroviruses and more recently herpes viruses in wildlife. He integrates ancient DNA, evolutionary and ecological analyses in most of his work and also has an interest in high throughput diagnostic methods. His work with Knut the polar bear intersected with the latter interest.

On Friday (23 December) we will post a second guest blog from another Scientific Reports author.