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In a randomized trial involving 50 opioid users on a waiting list for detoxification, 81% of users who received interim self-administered buprenorphine pills were abstinent over 12 weeks, as compared with 0% of those who did not receive buprenorphine.

During the first year of a nonjudgmental referral program for drug detoxification and rehabilitation managed by the police department in Gloucester, Massachusetts, 376 persons presented for assistance; 85% had insurance, and the rate of direct placement was 94%.

To the Editor: The incidence of cholangiocarcinoma in the general population is low; nevertheless, patients with primary sclerosing cholangitis face a lifetime risk of cholangiocarcinoma that is as high as 10%.¹ Lazaridis and LaRusso (Sept. 22 issue)² ...

To the Editor: Myeloma treatment with daratumumab shows an impressive efficacy and safety profile, as recently reported by Dimopoulos et al. in the POLLUX trial (Oct. 6 issue)¹ and by others.² However, we would appreciate a deeper discussion about the ...

To the Editor: In their interim report on the Andexanet Alfa, a Novel Antidote to the Anticoagulation Effects of FXA Inhibitors (ANNEXA-4) study, Connolly et al. (Sept. 22 issue)¹ report on the potential utility of andexanet alfa in reversing three factor ...

Determinants of antimicrobial resistance can be highly mobile. In this report, the diversity of carbapenem-resistant bacteria in a single patient over several years is investigated.

To the Editor: Cogswell et al. (Aug. 11 issue)¹ argue that the reported association between low sodium intake and increased cardiovascular risk does not fulfill the criteria for causality, and they therefore conclude that low sodium intake should be ...

To the Editor: In the Acute Medically Ill VTE (Venous Thromboembolism) Prevention with Extended Duration Betrixaban (APEX) trial, Cohen et al. (Aug. 11 issue)¹ analyzed whether the risk of venous thromboembolism was lower with extended-duration betrixaban ...

To the Editor: In the Randomised Evaluation of Surgery with Craniectomy for Uncontrollable Elevation of Intracranial Pressure (RESCUEicp) trial reported by Hutchinson and others (Sept. 22 issue),¹ mortality among patients with severe traumatic brain ...

In this follow-up report, the relationship between total anti–Ebola virus (EBOV) and EBOV neutralizing-antibody concentrations, in convalescent plasma used in the treatment of Ebola disease, was evaluated to determine the effect on efficacy.

To the Editor: The results of the Sleep Apnea Cardiovascular Endpoints (SAVE) study reported by McEvoy et al. (Sept. 8 issue)¹ provide the opportunity to reflect on the story of the glass that is half full. The study shows that if a person is not adherent ...

To the Editor: Genomic studies of cardiovascular disease that are based on samples obtained from patients have identified variants associated with the risk of disease that do not always predict the onset of disease shown in prospective studies.¹,² Dewey ...

To the Editor: Qureshi et al. (Sept. 15 issue)¹ report the results of the Antihypertensive Treatment of Acute Cerebral Hemorrhage II (ATACH-2) trial of blood-pressure lowering in patients with intracerebral hemorrhage. Though participants were assigned to ...

To the Editor: In their review article on thyroid cancer, Fagin and Wells (Sept. 15 issue)¹ state that 7% of unselected medullary thyroid carcinomas are attributable to germline RET mutations, but they do not provide a similar numerical estimate of genes ...

To the Editor: We describe a case of Zika virus (ZIKV) infection during pregnancy in a Colombian woman. She was infected in December 2015 while she was visiting her home country. At 9 weeks’ gestation, she had a self-limited maculopapular, nonconfluent ...

Deletion of chromosome arms 1p and 19q and mutations in IDH and TERT define prognostic subgroups of low-grade gliomas. Gliomas without these lesions (triple-negative gliomas) are more common in China, often have TP53 mutations, and are associated with a worse prognosis.

To the Editor: The results of the study by Cardoso et al. (Aug. 25 issue)¹ suggest that chemotherapy can be safely withheld from patients who are clinically at high risk for recurrence but have a low-risk 70-gene signature (MammaPrint). However, the ...

To the Editor: Pocock and Stone (Sept. 8 issue) provide an excellent primer on evaluations of clinical trials and their applications to practice.¹ However, early on in their article they make a common but erroneous statement regarding the nature of the P ...