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I'd like to compute $\sum_{i=0}^k {{N}\choose{i}}$. Is there a computable approximation for that?

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At first change your sigma to a definite integral by method of this post and after that use some approximation method about the definite integral. – Amin235 22 hours ago
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Possible duplicate of Sum of 'the first k' binomial coefficients for fixed n – Dirk 19 hours ago

One of the more convenient and popular approximations of the sum is

$$\frac{2^{nH(\frac{k}{n})}}{\sqrt{8k(1-\frac{k}{n})}} \leq \sum_{i=0}^k\binom{n}{i} \leq 2^{nH(\frac{k}{n})}$$

for $0< k < \frac{n}{2}$, where $H$ is the binary entropy function. (The upper bound is exactly what Aryeh Kontorovich mentions.) You can find its proof in many textbooks, but probably I first learned it from Chapter 10 of The Theory of Error-Correcting Codes by MacWilliams and Sloane.

Also, this post on MO asks a similar question and is a good resource for the sum in my opinion. You can find several other useful bounds there.

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Nice, I didn't know about the upper bound. That's probably as well as you can do, with such simple estimates. – Aryeh Kontorovich 18 hours ago

A well-known upper bound, for $k\le N/2$, is $$ \sum_{i=0}^k {N\choose i} \le 2^{N H(k/N)},$$ where $H$ is the binary entropy function $$ H(x) = -x\log_2(x)-(1-x)\log_2(1-x).$$ This bound was sharpened in Lemma 5 of http://www.sciencedirect.com/science/article/pii/S0012365X12000544

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