Oprah's Book Club is a book club segment of the American talk show The Oprah Winfrey Show, highlighting books chosen by host Oprah Winfrey. Winfrey started the book club in 1996 by selecting a new book each month. Because of the book club's wide popularity, many obscure titles have become very popular bestsellers, increasing sales by as many as a million copies at the height of the book club's popularity; this occurrence is known colloquially as the Oprah effect.

In 2002, Winfrey suspended the book club and revived it the following year, with the format shifted. In the new format, Winfrey would no longer be selecting a new book each month, but would instead select books on a more limited basis. Winfrey also began to focus on classic works of literature starting with the summer selection of East of Eden. In September 2005, Winfrey announced she would be opening the book club up to a wide range of titles and genres, including non-fiction and memoir.

Recently, Winfrey returned to fiction with her selection of The Road by Cormac McCarthy. Shortly after this selection, The Road was awarded the Pulitzer Prize for Fiction. Winfrey conducted the first ever television interview with McCarthy, a famously reclusive author, on June 5, 2007. On that same day, Winfrey revealed Middlesex (novel) by Jeffrey Eugenides as her 2007 Summer Selection.