Neural pathway

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A neural pathway connects one part of the nervous system with another.

Brain and spinal cord: neural tracts and fasciculi

Sensory/
ascending

PCML

1°:	Pacinian corpuscle/Meissner's corpuscle → Posterior column (Gracile fasciculus/Cuneate fasciculus) → Gracile nucleus/Cuneate nucleus

2°:	→ sensory decussation/arcuate fibers (Posterior external arcuate fibers, Internal arcuate fibers) → Medial lemniscus/Trigeminal lemniscus → Thalamus (VPL, VPM)

3°:	→ Posterior limb of internal capsule → Postcentral gyrus

Anterolateral/
pain

Fast/lateral	1° (Free nerve ending → A delta fiber) → 2° (Anterior white commissure → Lateral and Anterior Spinothalamic tract → Spinal lemniscus → VPL of Thalamus) → 3° (Postcentral gyrus) → 4° (Posterior parietal cortex) 2° (Spinomesencephalic tract → Superior colliculus of Midbrain tectum)

Slow/medial	1° (Group C nerve fiber → Spinoreticular tract → Reticular formation) → 2° (MD of Thalamus) → 3° (Cingulate cortex)

Motor/
descending

Pyramidal

flexion: Primary motor cortex → Posterior limb of internal capsule → Decussation of pyramids → Corticospinal tract (Lateral, Anterior) → Neuromuscular junction

Extrapyramidal

flexion:	Primary motor cortex → Genu of internal capsule → Corticobulbar tract → Facial motor nucleus → Facial muscles

flexion:	Red nucleus → Rubrospinal tract

extension:	Vestibulocerebellum → Vestibular nuclei → Vestibulospinal tract

extension:	Vestibulocerebellum → Reticular formation → Reticulospinal tract

Midbrain tectum → Tectospinal tract → muscles of neck

Basal ganglia

direct:	1° (Motor cortex → Striatum) → 2° (GPi) → 3° (Lenticular fasciculus/Ansa lenticularis → Thalamic fasciculus → VL of Thalamus) → 4° (Thalamocortical radiations → Supplementary motor area) → 5° (Motor cortex)

indirect:	1° (Motor cortex → Striatum) → 2° (GPe) → 3° (Subthalamic fasciculus → Subthalamic nucleus) → 4° (Subthalamic fasciculus → GPi) → 5° (Lenticular fasciculus/Ansa lenticularis → Thalamic fasciculus → VL of Thalamus) → 6° (Thalamocortical radiations → Supplementary motor area) → 7° (Motor cortex)

nigrostriatal pathway:	Pars compacta → Striatum

Cerebellar

Afferent

Vestibular nuclei → Vestibulocerebellar tract → ICP → Cerebellum → Granule cell

Pontine nuclei → Pontocerebellar fibers → MCP → Deep cerebellar nuclei → Granule cell

Inferior olivary nucleus → Olivocerebellar tract → ICP → Hemisphere → Purkinje cell → Deep cerebellar nuclei

Efferent

Dentate nucleus in Lateral hemisphere/pontocerebellum → SCP → Dentatothalamic tract → Thalamus (VL) → Motor cortex

Interposed nucleus in Intermediate hemisphere/spinocerebellum → SCP → Reticular formation, or → Cerebellothalamic tract → Red nucleus → Thalamus (VL) → Motor cortex

Fastigial nucleus in Flocculonodular lobe/vestibulocerebellum → Vestibulocerebellar tract → Vestibular nuclei

Bidirectional:
Spinocerebellar

Unconscious proprioception	lower limb → 1° (muscle spindles → DRG) → 2° (Posterior thoracic nucleus → Dorsal/posterior spinocerebellar tract → ICP → Cerebellar vermis) upper limb → 1° (muscle spindles → DRG) → 2° (Accessory cuneate nucleus → Cuneocerebellar tract → ICP → Anterior lobe of cerebellum)

Reflex arc	lower limb → 1° (Golgi tendon organ) → 2° (Ventral/anterior spinocerebellar tract→ SCP → Cerebellar vermis) upper limb → 1° (Golgi tendon organ) → 2° (Rostral spinocerebellar tract → ICP → Cerebellum)

v t e Optical illusions

List of optical illusions

Afterimage Barberpole Bezold Blivet Café wall Cornsweet Delboeuf Ebbinghaus Ehrenstein Flash lag Fraser spiral Grid Hering Jastrow Mach McCollough Müller-Lyer Necker Orbison Penrose stairs triangle Peripheral drift Poggendorff Ponzo Rubin Sander Schroeder Ternus Vertical–horizontal White's Wundt Zöllner

Related	Auditory Tactile Temporal Op art Ascending and Descending Waterfall

Physiology of balance and hearing

Hearing

General	Auditory system Bone conduction Otoacoustic emission Tullio phenomenon

Pathway	inner ear: Hair cells → Spiral ganglion → Cochlear nerve ^VIII → pons: Cochlear nucleus (Anterior, Dorsal) → Trapezoid body → Superior olivary nuclei → midbrain: Lateral lemniscus → Inferior colliculi → thalamus: Medial geniculate nuclei → cerebrum: Acoustic radiation → Primary auditory cortex

Balance

General	Vestibular system

Pathway	inner ear: Vestibular nerve ^VIII → pons: Vestibular nuclei (Medial vestibular nucleus, Lateral vestibular nucleus) cerebellum: Flocculonodular lobe spinal cord: Vestibulospinal tract (Medial vestibulospinal tract, Lateral vestibulospinal tract) thalamus: Ventral posterolateral nucleus cerebrum: Vestibular cortex Vestibulo-oculomotor fibers

v t e Papez circuit pathway

Diencephalon	Mammillary body → Mammillothalamic tract → Anterior nuclei of thalamus →

Telencephalon	Anterior limb of internal capsule → Cingulate gyrus → Cingulum → Parahippocampal gyrus → Entorhinal cortex → Perforant path → Hippocampus/Hippocampal formation (CA3 → CA1 → Subiculum) → Fornix →

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