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About UniProt

Last modified December 1, 2016

The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data. The UniProt databases are the UniProt Knowledgebase (UniProtKB), the UniProt Reference Clusters (UniRef), and the UniProt Archive (UniParc).

UniProt is a collaboration between the European Bioinformatics Institute (EMBL-EBI), the SIB Swiss Institute of Bioinformatics and the Protein Information Resource (PIR). Across the three institutes more than 100 people are involved through different tasks such as database curation, software development and support.

EMBL-EBI and SIB together used to produce Swiss-Prot and TrEMBL, while PIR produced the Protein Sequence Database (PIR-PSD). These two data sets coexisted with different protein sequence coverage and annotation priorities. TrEMBL (Translated EMBL Nucleotide Sequence Data Library) was originally created because sequence data was being generated at a pace that exceeded Swiss-Prot's ability to keep up. Meanwhile, PIR maintained the PIR-PSD and related databases, including iProClass, a database of protein sequences and curated families. In 2002 the three institutes decided to pool their resources and expertise and formed the UniProt consortium.

The UniProt consortium is headed by Alex Bateman (PI), Cathy Wu, and Ioannis Xenarios, supported by key staff, and receives valuable input from an independent Scientific Advisory Board.

Funding

UniProt is supported by the National Institutes of Health (NIH), National Human Genome Research Institute (NHGRI) and National Institute of General Medical Sciences (NIGMS) grant U41HG007822. Additional support for the EMBL-EBI's involvement in UniProt comes from European Molecular Biology Laboratory (EMBL), the British Heart Foundation (BHF) (RG/13/5/30112), the Parkinson's Disease United Kingdom (PDUK) GO grant G-1307, and the NIH GO grant U41HG02273. UniProt activities at the SIB are additionally supported by the Swiss Federal Government through the State Secretariat for Education, Research and Innovation SERI. PIR's UniProt activities are also supported by the NIH grants R01GM080646, G08LM010720, and P20GM103446, and the National Science Foundation (NSF) grant DBI-1062520.

Past funding

UniProt has been supported by the NIH grants U01HG02712 (2002-2010) and U41HG006104 (2010-2014).

UniProt activities at EMBL-EBI have benefited from the FP7 SLING project (2009-2012, contract number 226073) and a British Heart Foundation grant (SP/07/007/23671).

UniProt activities at SIB have benefited from EC support through the FP6 FELICS project (2006-2009, contract number 021902), and the FP7 projects SLING (2009-2012, contract number 226073), GEN2PHEN (2009-2013, contract number 200754), and MICROME (2009-2013, contract number 222886-2).

UniProt activities at PIR have benefited from NIH grants HHSN266200400061C (2004-2009), R01GM080646 (2007-2011), R01GM080646-04S2 (2009-2012), R01GM080646-07S1 (2012), and P20RR016472-09S2 (2009-2011), NSF grants DBI-0138188 (2002-2005) and IIS-0430743 (2004-2007), and UNIDEL Foundation award (2010-2012).

Further information

Contact the UniProt consortium members
EMBL Outstation

European Bioinformatics Institute (EMBL-EBI)

 Wellcome Trust Genome Campus

Hinxton CambridgeCB10 1SD

United Kingdom

 Phone: (+44 1223) 494 444

Fax: (+44 1223) 494 468
SIB Swiss Institute of Bioinformatics

Centre Medical Universitaire

1, rue Michel Servet

1211Geneva 4

Switzerland

 Phone: (+41 22) 702 50 50

Fax: (+41 22) 702 58 58
Protein Information Resource (PIR)

Georgetown University Medical Center

3300 Whitehaven Street NW

Suite 1200

Washington, DC 20007

United States of America

 Phone:( (+1 202) 687 1039

Fax: (+1 202) 687 0057)