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This Week in PNAS

Letters (Online Only)

  • Does culture get embrained?

    • Pierre O. Jacquet,
    • Nicolas Baumard,
    • and Coralie Chevallier
    PNAS 2016 113 (21) E2873; published ahead of print April 29, 2016, doi:10.1073/pnas.1603143113

  • Reply to Jacquet et al.: Culture and the neurobiology of norm violation detection

    • Yan Mu,
    • Shinobu Kitayama,
    • Shihui Han,
    • and Michele J. Gelfand
    PNAS 2016 113 (21) E2874-E2875; published ahead of print April 29, 2016, doi:10.1073/pnas.1603550113

  • Beyond the point of no return: Last-minute changes in human motor performance

    • Lüder Deecke and
    • Surjo R. Soekadar
    PNAS 2016 113 (21) E2876; published ahead of print May 4, 2016, doi:10.1073/pnas.1604257113

  • Reply to Deecke and Soekadar: Do conventional readiness potentials reflect true volitionality?

    • John-Dylan Haynes and
    • Matthias Schultze-Kraft
    PNAS 2016 113 (21) E2877-E2878; published ahead of print May 4, 2016, doi:10.1073/pnas.1604661113

Science and Culture

How science intersects with culture.

Inner Workings

An over-the-shoulder look at scientists at work.

Commentaries

  • Food deprivation induces presynaptic plasticity in the autonomic nervous system

    • Ronald W. Holz and
    • Arun Anantharam
    PNAS 2016 113 (21) 5766-5767; published ahead of print May 13, 2016, doi:10.1073/pnas.1605618113
    See companion article on page E3029 in issue 21 of volume 113

  • Ecosystem impacts of climate extremes crucially depend on the timing

    • Sebastian Sippel,
    • Jakob Zscheischler,
    • and Markus Reichstein
    PNAS 2016 113 (21) 5768-5770; published ahead of print May 13, 2016, doi:10.1073/pnas.1605667113
    See companion article on page 5880 in issue 21 of volume 113

  • Moving forward in perceptual decision making

    • Philipp Sterzer
    PNAS 2016 113 (21) 5771-5773; published ahead of print May 13, 2016, doi:10.1073/pnas.1605619113
    See companion article on page 6059 in issue 21 of volume 113

  • Molecular basis for differential light responses in Arabidopsis stems and leaves

    • Yun Hu and
    • Yunde Zhao
    PNAS 2016 113 (21) 5774-5776; published ahead of print May 13, 2016, doi:10.1073/pnas.1605750113
    See companion article on page 6071 in issue 21 of volume 113

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

Sackler Colloquium on Improving Our Fundamental Understanding of the Role of Aerosol–Cloud Interactions in the Climate System (Free Online)

Introduction

  • Improving our fundamental understanding of the role of aerosol−cloud interactions in the climate system

    • John H. Seinfeld,
    • Christopher Bretherton,
    • Kenneth S. Carslaw,
    • Hugh Coe,
    • Paul J. DeMott,
    • Edward J. Dunlea,
    • Graham Feingold,
    • Steven Ghan,
    • Alex B. Guenther,
    • Ralph Kahn,
    • Ian Kraucunas,
    • Sonia M. Kreidenweis,
    • Mario J. Molina,
    • Athanasios Nenes,
    • Joyce E. Penner,
    • Kimberly A. Prather,
    • V. Ramanathan,
    • Venkatachalam Ramaswamy,
    • Philip J. Rasch,
    • A. R. Ravishankara,
    • Daniel Rosenfeld,
    • Graeme Stephens,
    • and Robert Wood
    PNAS 2016 113 (21) 5781-5790; doi:10.1073/pnas.1514043113

Colloquium Papers

  • Role of updraft velocity in temporal variability of global cloud hydrometeor number

    • Sylvia C. Sullivan,
    • Dongmin Lee,
    • Lazaros Oreopoulos,
    • and Athanasios Nenes
    PNAS 2016 113 (21) 5791-5796; published ahead of print May 16, 2016, doi:10.1073/pnas.1514039113

  • Sea spray aerosol as a unique source of ice nucleating particles

    • Paul J. DeMott,
    • Thomas C. J. Hill,
    • Christina S. McCluskey,
    • Kimberly A. Prather,
    • Douglas B. Collins,
    • Ryan C. Sullivan,
    • Matthew J. Ruppel,
    • Ryan H. Mason,
    • Victoria E. Irish,
    • Taehyoung Lee,
    • Chung Yeon Hwang,
    • Tae Siek Rhee,
    • Jefferson R. Snider,
    • Gavin R. McMeeking,
    • Suresh Dhaniyala,
    • Ernie R. Lewis,
    • Jeremy J. B. Wentzell,
    • Jonathan Abbatt,
    • Christopher Lee,
    • Camille M. Sultana,
    • Andrew P. Ault,
    • Jessica L. Axson,
    • Myrelis Diaz Martinez,
    • Ingrid Venero,
    • Gilmarie Santos-Figueroa,
    • M. Dale Stokes,
    • Grant B. Deane,
    • Olga L. Mayol-Bracero,
    • Vicki H. Grassian,
    • Timothy H. Bertram,
    • Allan K. Bertram,
    • Bruce F. Moffett,
    • and Gary D. Franc
    PNAS 2016 113 (21) 5797-5803; published ahead of print December 22, 2015, doi:10.1073/pnas.1514034112

  • Challenges in constraining anthropogenic aerosol effects on cloud radiative forcing using present-day spatiotemporal variability

    • Steven Ghan,
    • Minghuai Wang,
    • Shipeng Zhang,
    • Sylvaine Ferrachat,
    • Andrew Gettelman,
    • Jan Griesfeller,
    • Zak Kipling,
    • Ulrike Lohmann,
    • Hugh Morrison,
    • David Neubauer,
    • Daniel G. Partridge,
    • Philip Stier,
    • Toshihiko Takemura,
    • Hailong Wang,
    • and Kai Zhang
    PNAS 2016 113 (21) 5804-5811; published ahead of print February 26, 2016, doi:10.1073/pnas.1514036113

  • New approaches to quantifying aerosol influence on the cloud radiative effect

    • Graham Feingold,
    • Allison McComiskey,
    • Takanobu Yamaguchi,
    • Jill S. Johnson,
    • Kenneth S. Carslaw,
    • and K. Sebastian Schmidt
    PNAS 2016 113 (21) 5812-5819; published ahead of print February 1, 2016, doi:10.1073/pnas.1514035112

  • On the relationship between aerosol model uncertainty and radiative forcing uncertainty

    • Lindsay A. Lee,
    • Carly L. Reddington,
    • and Kenneth S. Carslaw
    PNAS 2016 113 (21) 5820-5827; published ahead of print February 4, 2016, doi:10.1073/pnas.1507050113

  • Satellite retrieval of cloud condensation nuclei concentrations by using clouds as CCN chambers

    • Daniel Rosenfeld,
    • Youtong Zheng,
    • Eyal Hashimshoni,
    • Mira L. Pöhlker,
    • Anne Jefferson,
    • Christopher Pöhlker,
    • Xing Yu,
    • Yannian Zhu,
    • Guihua Liu,
    • Zhiguo Yue,
    • Baruch Fischman,
    • Zhanqing Li,
    • David Giguzin,
    • Tom Goren,
    • Paulo Artaxo,
    • Henrique M. J. Barbosa,
    • Ulrich Pöschl,
    • and Meinrat O. Andreae
    PNAS 2016 113 (21) 5828-5834; published ahead of print March 4, 2016, doi:10.1073/pnas.1514044113

Physical Sciences

Applied Physical Sciences

Chemistry

  • Bacteria in an intense competition for iron: Key component of the Campylobacter jejuni iron uptake system scavenges enterobactin hydrolysis product

    • Daniel J. Raines,
    • Olga V. Moroz,
    • Elena V. Blagova,
    • Johan P. Turkenburg,
    • Keith S. Wilson,
    • and Anne-K. Duhme-Klair
    PNAS 2016 113 (21) 5850-5855; published ahead of print May 9, 2016, doi:10.1073/pnas.1520829113
    OPEN ACCESS ARTICLE

  • Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNaV1.7

    • Rhiannon Thomas-Tran and
    • J. Du Bois
    PNAS 2016 113 (21) 5856-5861; published ahead of print May 9, 2016, doi:10.1073/pnas.1603486113

  • Design of a small molecule against an oncogenic noncoding RNA

    • Sai Pradeep Velagapudi,
    • Michael D. Cameron,
    • Christopher L. Haga,
    • Laura H. Rosenberg,
    • Marie Lafitte,
    • Derek R. Duckett,
    • Donald G. Phinney,
    • and Matthew D. Disney
    PNAS 2016 113 (21) 5898-5903; published ahead of print May 11, 2016, doi:10.1073/pnas.1523975113

Earth, Atmospheric, and Planetary Sciences

  • Role of updraft velocity in temporal variability of global cloud hydrometeor number

    • Sylvia C. Sullivan,
    • Dongmin Lee,
    • Lazaros Oreopoulos,
    • and Athanasios Nenes
    PNAS 2016 113 (21) 5791-5796; published ahead of print May 16, 2016, doi:10.1073/pnas.1514039113

  • Sea spray aerosol as a unique source of ice nucleating particles

    • Paul J. DeMott,
    • Thomas C. J. Hill,
    • Christina S. McCluskey,
    • Kimberly A. Prather,
    • Douglas B. Collins,
    • Ryan C. Sullivan,
    • Matthew J. Ruppel,
    • Ryan H. Mason,
    • Victoria E. Irish,
    • Taehyoung Lee,
    • Chung Yeon Hwang,
    • Tae Siek Rhee,
    • Jefferson R. Snider,
    • Gavin R. McMeeking,
    • Suresh Dhaniyala,
    • Ernie R. Lewis,
    • Jeremy J. B. Wentzell,
    • Jonathan Abbatt,
    • Christopher Lee,
    • Camille M. Sultana,
    • Andrew P. Ault,
    • Jessica L. Axson,
    • Myrelis Diaz Martinez,
    • Ingrid Venero,
    • Gilmarie Santos-Figueroa,
    • M. Dale Stokes,
    • Grant B. Deane,
    • Olga L. Mayol-Bracero,
    • Vicki H. Grassian,
    • Timothy H. Bertram,
    • Allan K. Bertram,
    • Bruce F. Moffett,
    • and Gary D. Franc
    PNAS 2016 113 (21) 5797-5803; published ahead of print December 22, 2015, doi:10.1073/pnas.1514034112

  • Challenges in constraining anthropogenic aerosol effects on cloud radiative forcing using present-day spatiotemporal variability

    • Steven Ghan,
    • Minghuai Wang,
    • Shipeng Zhang,
    • Sylvaine Ferrachat,
    • Andrew Gettelman,
    • Jan Griesfeller,
    • Zak Kipling,
    • Ulrike Lohmann,
    • Hugh Morrison,
    • David Neubauer,
    • Daniel G. Partridge,
    • Philip Stier,
    • Toshihiko Takemura,
    • Hailong Wang,
    • and Kai Zhang
    PNAS 2016 113 (21) 5804-5811; published ahead of print February 26, 2016, doi:10.1073/pnas.1514036113

  • New approaches to quantifying aerosol influence on the cloud radiative effect

    • Graham Feingold,
    • Allison McComiskey,
    • Takanobu Yamaguchi,
    • Jill S. Johnson,
    • Kenneth S. Carslaw,
    • and K. Sebastian Schmidt
    PNAS 2016 113 (21) 5812-5819; published ahead of print February 1, 2016, doi:10.1073/pnas.1514035112

  • On the relationship between aerosol model uncertainty and radiative forcing uncertainty

    • Lindsay A. Lee,
    • Carly L. Reddington,
    • and Kenneth S. Carslaw
    PNAS 2016 113 (21) 5820-5827; published ahead of print February 4, 2016, doi:10.1073/pnas.1507050113

  • Satellite retrieval of cloud condensation nuclei concentrations by using clouds as CCN chambers

    • Daniel Rosenfeld,
    • Youtong Zheng,
    • Eyal Hashimshoni,
    • Mira L. Pöhlker,
    • Anne Jefferson,
    • Christopher Pöhlker,
    • Xing Yu,
    • Yannian Zhu,
    • Guihua Liu,
    • Zhiguo Yue,
    • Baruch Fischman,
    • Zhanqing Li,
    • David Giguzin,
    • Tom Goren,
    • Paulo Artaxo,
    • Henrique M. J. Barbosa,
    • Ulrich Pöschl,
    • and Meinrat O. Andreae
    PNAS 2016 113 (21) 5828-5834; published ahead of print March 4, 2016, doi:10.1073/pnas.1514044113

  • Probing the metabolic water contribution to intracellular water using oxygen isotope ratios of PO4

    • Hui Li,
    • Chan Yu,
    • Fei Wang,
    • Sae Jung Chang,
    • Jun Yao,
    • and Ruth E. Blake
    PNAS 2016 113 (21) 5862-5867; published ahead of print May 11, 2016, doi:10.1073/pnas.1521038113

  • Halogen radicals contribute to photooxidation in coastal and estuarine waters

    • Kimberly M. Parker and
    • William A. Mitch
    PNAS 2016 113 (21) 5868-5873; published ahead of print May 9, 2016, doi:10.1073/pnas.1602595113

Engineering

Environmental Sciences

  • Increasing importance of deposition of reduced nitrogen in the United States

    • Yi Li,
    • Bret A. Schichtel,
    • John T. Walker,
    • Donna B. Schwede,
    • Xi Chen,
    • Christopher M. B. Lehmann,
    • Melissa A. Puchalski,
    • David A. Gay,
    • and Jeffrey L. Collett Jr.
    PNAS 2016 113 (21) 5874-5879; published ahead of print May 9, 2016, doi:10.1073/pnas.1525736113
    OPEN ACCESS ARTICLE

  • Warm spring reduced carbon cycle impact of the 2012 US summer drought

    • Sebastian Wolf,
    • Trevor F. Keenan,
    • Joshua B. Fisher,
    • Dennis D. Baldocchi,
    • Ankur R. Desai,
    • Andrew D. Richardson,
    • Russell L. Scott,
    • Beverly E. Law,
    • Marcy E. Litvak,
    • Nathaniel A. Brunsell,
    • Wouter Peters,
    • and Ingrid T. van der Laan-Luijkx
    PNAS 2016 113 (21) 5880-5885; published ahead of print April 25, 2016, doi:10.1073/pnas.1519620113
    See Commentary on page 5768 in issue 21 of volume 113

  • Saharan dust nutrients promote Vibrio bloom formation in marine surface waters

    • Jason R. Westrich,
    • Alina M. Ebling,
    • William M. Landing,
    • Jessica L. Joyner,
    • Keri M. Kemp,
    • Dale W. Griffin,
    • and Erin K. Lipp
    PNAS 2016 113 (21) 5964-5969; published ahead of print May 9, 2016, doi:10.1073/pnas.1518080113
    OPEN ACCESS ARTICLE

Physics

Social Sciences

Environmental Sciences

  • Estimating option values of solar radiation management assuming that climate sensitivity is uncertain

    • Yosuke Arino,
    • Keigo Akimoto,
    • Fuminori Sano,
    • Takashi Homma,
    • Junichiro Oda,
    • and Toshimasa Tomoda
    PNAS 2016 113 (21) 5886-5891; published ahead of print May 9, 2016, doi:10.1073/pnas.1520795113

Sustainability Science

  • Estimating option values of solar radiation management assuming that climate sensitivity is uncertain

    • Yosuke Arino,
    • Keigo Akimoto,
    • Fuminori Sano,
    • Takashi Homma,
    • Junichiro Oda,
    • and Toshimasa Tomoda
    PNAS 2016 113 (21) 5886-5891; published ahead of print May 9, 2016, doi:10.1073/pnas.1520795113

Biological Sciences

Applied Biological Sciences

Biochemistry

  • Interactions between RNA polymerase and the core recognition element are a determinant of transcription start site selection

    • Irina O. Vvedenskaya,
    • Hanif Vahedian-Movahed,
    • Yuanchao Zhang,
    • Deanne M. Taylor,
    • Richard H. Ebright,
    • and Bryce E. Nickels
    PNAS 2016 113 (21) E2899-E2905; published ahead of print May 9, 2016, doi:10.1073/pnas.1603271113

  • Myosin MyTH4-FERM structures highlight important principles of convergent evolution

    • Vicente José Planelles-Herrero,
    • Florian Blanc,
    • Serena Sirigu,
    • Helena Sirkia,
    • Jeffrey Clause,
    • Yannick Sourigues,
    • Daniel O. Johnsrud,
    • Beatrice Amigues,
    • Marco Cecchini,
    • Susan P. Gilbert,
    • Anne Houdusse,
    • and Margaret A. Titus
    PNAS 2016 113 (21) E2906-E2915; published ahead of print May 10, 2016, doi:10.1073/pnas.1600736113

  • Bacteria in an intense competition for iron: Key component of the Campylobacter jejuni iron uptake system scavenges enterobactin hydrolysis product

    • Daniel J. Raines,
    • Olga V. Moroz,
    • Elena V. Blagova,
    • Johan P. Turkenburg,
    • Keith S. Wilson,
    • and Anne-K. Duhme-Klair
    PNAS 2016 113 (21) 5850-5855; published ahead of print May 9, 2016, doi:10.1073/pnas.1520829113
    OPEN ACCESS ARTICLE

  • Design of a small molecule against an oncogenic noncoding RNA

    • Sai Pradeep Velagapudi,
    • Michael D. Cameron,
    • Christopher L. Haga,
    • Laura H. Rosenberg,
    • Marie Lafitte,
    • Derek R. Duckett,
    • Donald G. Phinney,
    • and Matthew D. Disney
    PNAS 2016 113 (21) 5898-5903; published ahead of print May 11, 2016, doi:10.1073/pnas.1523975113

  • Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols

    • Navdar Sever,
    • Randall K. Mann,
    • Libin Xu,
    • William J. Snell,
    • Carmen I. Hernandez-Lara,
    • Ned A. Porter,
    • and Philip A. Beachy
    PNAS 2016 113 (21) 5904-5909; published ahead of print May 9, 2016, doi:10.1073/pnas.1604984113

  • Enhancing protein stability with extended disulfide bonds

    • Tao Liu,
    • Yan Wang,
    • Xiaozhou Luo,
    • Jack Li,
    • Sean A. Reed,
    • Han Xiao,
    • Travis S. Young,
    • and Peter G. Schultz
    PNAS 2016 113 (21) 5910-5915; published ahead of print May 9, 2016, doi:10.1073/pnas.1605363113

  • Primer release is the rate-limiting event in lagging-strand synthesis mediated by the T7 replisome

    • Alfredo J. Hernandez,
    • Seung-Joo Lee,
    • and Charles C. Richardson
    PNAS 2016 113 (21) 5916-5921; published ahead of print May 9, 2016, doi:10.1073/pnas.1604894113

  • Interactions of a fungal lytic polysaccharide monooxygenase with β-glucan substrates and cellobiose dehydrogenase

    • Gaston Courtade,
    • Reinhard Wimmer,
    • Åsmund K. Røhr,
    • Marita Preims,
    • Alfons K. G. Felice,
    • Maria Dimarogona,
    • Gustav Vaaje-Kolstad,
    • Morten Sørlie,
    • Mats Sandgren,
    • Roland Ludwig,
    • Vincent G. H. Eijsink,
    • and Finn Lillelund Aachmann
    PNAS 2016 113 (21) 5922-5927; published ahead of print May 5, 2016, doi:10.1073/pnas.1602566113

  • Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency

    • Stefka D. Spassieva,
    • Xiaojie Ji,
    • Ye Liu,
    • Kenneth Gable,
    • Jacek Bielawski,
    • Teresa M. Dunn,
    • Erhard Bieberich,
    • and Lihong Zhao
    PNAS 2016 113 (21) 5928-5933; published ahead of print May 9, 2016, doi:10.1073/pnas.1522071113

  • Direct and essential function for Hrd3 in ER-associated degradation

    • Nidhi Vashistha,
    • Sonya E. Neal,
    • Amanjot Singh,
    • Sarah M. Carroll,
    • and Randolph Y. Hampton
    PNAS 2016 113 (21) 5934-5939; published ahead of print May 11, 2016, doi:10.1073/pnas.1603079113

Biophysics and Computational Biology

  • Achieving diverse and monoallelic olfactory receptor selection through dual-objective optimization design

    • Xiao-Jun Tian,
    • Hang Zhang,
    • Jens Sannerud,
    • and Jianhua Xing
    PNAS 2016 113 (21) E2889-E2898; published ahead of print May 9, 2016, doi:10.1073/pnas.1601722113

  • F1-ATPase conformational cycle from simultaneous single-molecule FRET and rotation measurements

    • Mitsuhiro Sugawa,
    • Kei-ichi Okazaki,
    • Masaru Kobayashi,
    • Takashi Matsui,
    • Gerhard Hummer,
    • Tomoko Masaike,
    • and Takayuki Nishizaka
    PNAS 2016 113 (21) E2916-E2924; published ahead of print May 10, 2016, doi:10.1073/pnas.1524720113

  • Keratin network modifications lead to the mechanical stiffening of the hair follicle fiber

    • Thomas Bornschlögl,
    • Lucien Bildstein,
    • Sébastien Thibaut,
    • Roberto Santoprete,
    • Françoise Fiat,
    • Gustavo S. Luengo,
    • Jean Doucet,
    • Bruno A. Bernard,
    • and Nawel Baghdadli
    PNAS 2016 113 (21) 5940-5945; published ahead of print May 9, 2016, doi:10.1073/pnas.1520302113
    OPEN ACCESS ARTICLE

Cell Biology

  • Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused by TTLL5 mutations

    • Xun Sun,
    • James H. Park,
    • Jessica Gumerson,
    • Zhijian Wu,
    • Anand Swaroop,
    • Haohua Qian,
    • Antonina Roll-Mecak,
    • and Tiansen Li
    PNAS 2016 113 (21) E2925-E2934; published ahead of print May 9, 2016, doi:10.1073/pnas.1523201113

  • Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivo

    • Xiaochen Zhou,
    • Mingjia Tan,
    • Mukesh K. Nyati,
    • Yongchao Zhao,
    • Gongxian Wang,
    • and Yi Sun
    PNAS 2016 113 (21) E2935-E2944; published ahead of print May 9, 2016, doi:10.1073/pnas.1522367113
    OPEN ACCESS ARTICLE

  • USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds

    • Babita Madan,
    • Matthew P. Walker,
    • Robert Young,
    • Laura Quick,
    • Kelly A. Orgel,
    • Meagan Ryan,
    • Priti Gupta,
    • Ian C. Henrich,
    • Marc Ferrer,
    • Shane Marine,
    • Brian S. Roberts,
    • William T. Arthur,
    • Jason D. Berndt,
    • Andre M. Oliveira,
    • Randall T. Moon,
    • David M. Virshup,
    • Margaret M. Chou,
    • and Michael B. Major
    PNAS 2016 113 (21) E2945-E2954; published ahead of print May 9, 2016, doi:10.1073/pnas.1605691113

  • Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals

    • Chun-Chun Li,
    • Kang Le,
    • Jiro Kato,
    • Joel Moss,
    • and Martha Vaughan
    PNAS 2016 113 (21) 5946-5951; published ahead of print May 9, 2016, doi:10.1073/pnas.1601918113

  • Optogenetic toolkit reveals the role of Ca2+ sparklets in coordinated cell migration

    • Jin Man Kim,
    • Minji Lee,
    • Nury Kim,
    • and Won Do Heo
    PNAS 2016 113 (21) 5952-5957; published ahead of print May 17, 2016, doi:10.1073/pnas.1518412113

  • A repeat protein links Rubisco to form the eukaryotic carbon-concentrating organelle

    • Luke C. M. Mackinder,
    • Moritz T. Meyer,
    • Tabea Mettler-Altmann,
    • Vivian K. Chen,
    • Madeline C. Mitchell,
    • Oliver Caspari,
    • Elizabeth S. Freeman Rosenzweig,
    • Leif Pallesen,
    • Gregory Reeves,
    • Alan Itakura,
    • Robyn Roth,
    • Frederik Sommer,
    • Stefan Geimer,
    • Timo Mühlhaus,
    • Michael Schroda,
    • Ursula Goodenough,
    • Mark Stitt,
    • Howard Griffiths,
    • and Martin C. Jonikas
    PNAS 2016 113 (21) 5958-5963; published ahead of print May 10, 2016, doi:10.1073/pnas.1522866113
    OPEN ACCESS ARTICLE

Developmental Biology

  • PDK1–Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex

    • Yasuhiro Itoh,
    • Maiko Higuchi,
    • Koji Oishi,
    • Yusuke Kishi,
    • Tomohiko Okazaki,
    • Hiroshi Sakai,
    • Takaki Miyata,
    • Kazunori Nakajima,
    • and Yukiko Gotoh
    PNAS 2016 113 (21) E2955-E2964; published ahead of print May 11, 2016, doi:10.1073/pnas.1516321113

Ecology

Environmental Sciences

  • Increasing importance of deposition of reduced nitrogen in the United States

    • Yi Li,
    • Bret A. Schichtel,
    • John T. Walker,
    • Donna B. Schwede,
    • Xi Chen,
    • Christopher M. B. Lehmann,
    • Melissa A. Puchalski,
    • David A. Gay,
    • and Jeffrey L. Collett Jr.
    PNAS 2016 113 (21) 5874-5879; published ahead of print May 9, 2016, doi:10.1073/pnas.1525736113
    OPEN ACCESS ARTICLE

Evolution

Genetics

  • mir-276a strengthens Drosophila circadian rhythms by regulating timeless expression

    • Xiao Chen and
    • Michael Rosbash
    PNAS 2016 113 (21) E2965-E2972; published ahead of print May 9, 2016, doi:10.1073/pnas.1605837113

  • Expression of tandem gene duplicates is often greater than twofold

    • David W. Loehlin and
    • Sean B. Carroll
    PNAS 2016 113 (21) 5988-5992; published ahead of print May 9, 2016, doi:10.1073/pnas.1605886113
    OPEN ACCESS ARTICLE

  • ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice

    • Oscar Diaz-Horta,
    • Clemer Abad,
    • Levent Sennaroglu,
    • Joseph Foster II,
    • Alexandra DeSmidt,
    • Guney Bademci,
    • Suna Tokgoz-Yilmaz,
    • Duygu Duman,
    • F. Basak Cengiz,
    • M’hamed Grati,
    • Suat Fitoz,
    • Xue Z. Liu,
    • Amjad Farooq,
    • Faiqa Imtiaz,
    • Benjamin B. Currall,
    • Cynthia Casson Morton,
    • Michiru Nishita,
    • Yasuhiro Minami,
    • Zhongmin Lu,
    • Katherina Walz,
    • and Mustafa Tekin
    PNAS 2016 113 (21) 5993-5998; published ahead of print May 9, 2016, doi:10.1073/pnas.1522512113

Immunology and Inflammation

  • Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation

    • Catharina C. Gross,
    • Andreas Schulte-Mecklenbeck,
    • Anna Rünzi,
    • Tanja Kuhlmann,
    • Anita Posevitz-Fejfár,
    • Nicholas Schwab,
    • Tilman Schneider-Hohendorf,
    • Sebastian Herich,
    • Kathrin Held,
    • Matea Konjević,
    • Marvin Hartwig,
    • Klaus Dornmair,
    • Reinhard Hohlfeld,
    • Tjalf Ziemssen,
    • Luisa Klotz,
    • Sven G. Meuth,
    • and Heinz Wiendl
    PNAS 2016 113 (21) E2973-E2982; published ahead of print May 9, 2016, doi:10.1073/pnas.1524924113

  • Restricting nonclassical MHC genes coevolve with TRAV genes used by innate-like T cells in mammals

    • Pierre Boudinot,
    • Stanislas Mondot,
    • Luc Jouneau,
    • Luc Teyton,
    • Marie-Paule Lefranc,
    • and Olivier Lantz
    PNAS 2016 113 (21) E2983-E2992; published ahead of print May 11, 2016, doi:10.1073/pnas.1600674113

  • Histone deacetylase inhibition enhances antimicrobial peptide but not inflammatory cytokine expression upon bacterial challenge

    • Natalie Fischer,
    • Emmanuel Sechet,
    • Robin Friedman,
    • Aurélien Amiot,
    • Iradj Sobhani,
    • Giulia Nigro,
    • Philippe J. Sansonetti,
    • and Brice Sperandio
    PNAS 2016 113 (21) E2993-E3001; published ahead of print May 9, 2016, doi:10.1073/pnas.1605997113

  • NLRC5/MHC class I transactivator is a target for immune evasion in cancer

    • Sayuri Yoshihama,
    • Jason Roszik,
    • Isaac Downs,
    • Torsten B. Meissner,
    • Saptha Vijayan,
    • Bjoern Chapuy,
    • Tabasum Sidiq,
    • Margaret A. Shipp,
    • Gregory A. Lizee,
    • and Koichi S. Kobayashi
    PNAS 2016 113 (21) 5999-6004; published ahead of print May 9, 2016, doi:10.1073/pnas.1602069113

Medical Sciences

  • Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort

    • Zhuo Chen,
    • Feng Miao,
    • Andrew D. Paterson,
    • John M. Lachin,
    • Lingxiao Zhang,
    • Dustin E. Schones,
    • Xiwei Wu,
    • Jinhui Wang,
    • Joshua D. Tompkins,
    • Saul Genuth,
    • Barbara H. Braffett,
    • Arthur D. Riggs,
    • DCCT/EDIC Research Group,
    • and Rama Natarajan
    PNAS 2016 113 (21) E3002-E3011; published ahead of print May 9, 2016, doi:10.1073/pnas.1603712113
    OPEN ACCESS ARTICLE

  • Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues

    • Jeffrey D. Krimmel,
    • Michael W. Schmitt,
    • Maria I. Harrell,
    • Kathy J. Agnew,
    • Scott R. Kennedy,
    • Mary J. Emond,
    • Lawrence A. Loeb,
    • Elizabeth M. Swisher,
    • and Rosa Ana Risques
    PNAS 2016 113 (21) 6005-6010; published ahead of print May 5, 2016, doi:10.1073/pnas.1601311113

  • Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1α and improve limb revascularization

    • Yosuke Watanabe,
    • Colin E. Murdoch,
    • Soichi Sano,
    • Yasuo Ido,
    • Markus M. Bachschmid,
    • Richard A. Cohen,
    • and Reiko Matsui
    PNAS 2016 113 (21) 6011-6016; published ahead of print May 9, 2016, doi:10.1073/pnas.1524198113

Microbiology

  • Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania

    • Élodie Gazanion,
    • Christopher Fernández-Prada,
    • Barbara Papadopoulou,
    • Philippe Leprohon,
    • and Marc Ouellette
    PNAS 2016 113 (21) E3012-E3021; published ahead of print May 9, 2016, doi:10.1073/pnas.1520693113

  • PML plays both inimical and beneficial roles in HSV-1 replication

    • Pei Xu,
    • Stephen Mallon,
    • and Bernard Roizman
    PNAS 2016 113 (21) E3022-E3028; published ahead of print May 9, 2016, doi:10.1073/pnas.1605513113

  • Probing the metabolic water contribution to intracellular water using oxygen isotope ratios of PO4

    • Hui Li,
    • Chan Yu,
    • Fei Wang,
    • Sae Jung Chang,
    • Jun Yao,
    • and Ruth E. Blake
    PNAS 2016 113 (21) 5862-5867; published ahead of print May 11, 2016, doi:10.1073/pnas.1521038113

  • Type IV pilins regulate their own expression via direct intramembrane interactions with the sensor kinase PilS

    • Sara L. N. Kilmury and
    • Lori L. Burrows
    PNAS 2016 113 (21) 6017-6022; published ahead of print May 9, 2016, doi:10.1073/pnas.1512947113

Neuroscience

  • Fasting induces a form of autonomic synaptic plasticity that prevents hypoglycemia

    • Manqi Wang,
    • Qian Wang,
    • and Matthew D. Whim
    PNAS 2016 113 (21) E3029-E3038; published ahead of print April 18, 2016, doi:10.1073/pnas.1517275113
    See Commentary on page 5766 in issue 21 of volume 113

  • Mesolimbic neuropeptide W coordinates stress responses under novel environments

    • Toshiyuki Motoike,
    • Jeffrey M. Long,
    • Hirokazu Tanaka,
    • Christopher M. Sinton,
    • Amber Skach,
    • S. Clay Williams,
    • Robert E. Hammer,
    • Takeshi Sakurai,
    • and Masashi Yanagisawa
    PNAS 2016 113 (21) 6023-6028; published ahead of print May 2, 2016, doi:10.1073/pnas.1518658113

  • Prevalent presence of periodic actin–spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species

    • Jiang He,
    • Ruobo Zhou,
    • Zhuhao Wu,
    • Monica A. Carrasco,
    • Peri T. Kurshan,
    • Jonathan E. Farley,
    • David J. Simon,
    • Guiping Wang,
    • Boran Han,
    • Junjie Hao,
    • Evan Heller,
    • Marc R. Freeman,
    • Kang Shen,
    • Tom Maniatis,
    • Marc Tessier-Lavigne,
    • and Xiaowei Zhuang
    PNAS 2016 113 (21) 6029-6034; published ahead of print May 9, 2016, doi:10.1073/pnas.1605707113
    OPEN ACCESS ARTICLE

  • Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides

    • Sunil K. Sukumaran,
    • Karen K. Yee,
    • Shusuke Iwata,
    • Ramana Kotha,
    • Roberto Quezada-Calvillo,
    • Buford L. Nichols,
    • Sankar Mohan,
    • B. Mario Pinto,
    • Noriatsu Shigemura,
    • Yuzo Ninomiya,
    • and Robert F. Margolskee
    PNAS 2016 113 (21) 6035-6040; published ahead of print May 9, 2016, doi:10.1073/pnas.1520843113

  • Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity

    • Achla Gupta,
    • Ivone Gomes,
    • Erin N. Bobeck,
    • Amanda K. Fakira,
    • Nicholas P. Massaro,
    • Indrajeet Sharma,
    • Adrien Cavé,
    • Heidi E. Hamm,
    • Joseph Parello,
    • and Lakshmi A. Devi
    PNAS 2016 113 (21) 6041-6046; published ahead of print May 9, 2016, doi:10.1073/pnas.1521825113

  • Architecture of retinal projections to the central circadian pacemaker

    • Diego Carlos Fernandez,
    • Yi-Ting Chang,
    • Samer Hattar,
    • and Shih-Kuo Chen
    PNAS 2016 113 (21) 6047-6052; published ahead of print May 9, 2016, doi:10.1073/pnas.1523629113

  • Deep-brain photoreception links luminance detection to motor output in Xenopus frog tadpoles

    • Stephen P. Currie,
    • Gayle H. Doherty,
    • and Keith T. Sillar
    PNAS 2016 113 (21) 6053-6058; published ahead of print May 10, 2016, doi:10.1073/pnas.1515516113

  • Causal evidence for frontal cortex organization for perceptual decision making

    • Dobromir Rahnev,
    • Derek Evan Nee,
    • Justin Riddle,
    • Alina Sue Larson,
    • and Mark D’Esposito
    PNAS 2016 113 (21) 6059-6064; published ahead of print May 9, 2016, doi:10.1073/pnas.1522551113
    OPEN ACCESS ARTICLE
    See Commentary on page 5771 in issue 21 of volume 113

Pharmacology

  • Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNaV1.7

    • Rhiannon Thomas-Tran and
    • J. Du Bois
    PNAS 2016 113 (21) 5856-5861; published ahead of print May 9, 2016, doi:10.1073/pnas.1603486113

Physiology

  • Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments

    • Thomas Kampourakis,
    • Yin-Biao Sun,
    • and Malcolm Irving
    PNAS 2016 113 (21) E3039-E3047; published ahead of print May 9, 2016, doi:10.1073/pnas.1602776113
    OPEN ACCESS ARTICLE

Plant Biology

  • Luminidependens (LD) is an Arabidopsis protein with prion behavior

    • Sohini Chakrabortee,
    • Can Kayatekin,
    • Greg A. Newby,
    • Marc L. Mendillo,
    • Alex Lancaster,
    • and Susan Lindquist
    PNAS 2016 113 (21) 6065-6070; published ahead of print April 25, 2016, doi:10.1073/pnas.1604478113

  • Arabidopsis SAURs are critical for differential light regulation of the development of various organs

    • Ning Sun,
    • Jiajun Wang,
    • Zhaoxu Gao,
    • Jie Dong,
    • Hang He,
    • William Terzaghi,
    • Ning Wei,
    • Xing Wang Deng,
    • and Haodong Chen
    PNAS 2016 113 (21) 6071-6076; published ahead of print April 26, 2016, doi:10.1073/pnas.1604782113
    See Commentary on page 5774 in issue 21 of volume 113

  • Self-regulating genomic island encoding tandem regulators confers chromatic acclimation to marine Synechococcus

    • Joseph E. Sanfilippo,
    • Adam A. Nguyen,
    • Jonathan A. Karty,
    • Animesh Shukla,
    • Wendy M. Schluchter,
    • Laurence Garczarek,
    • Frédéric Partensky,
    • and David M. Kehoe
    PNAS 2016 113 (21) 6077-6082; published ahead of print May 5, 2016, doi:10.1073/pnas.1600625113

Sustainability Science

  • Warm spring reduced carbon cycle impact of the 2012 US summer drought

    • Sebastian Wolf,
    • Trevor F. Keenan,
    • Joshua B. Fisher,
    • Dennis D. Baldocchi,
    • Ankur R. Desai,
    • Andrew D. Richardson,
    • Russell L. Scott,
    • Beverly E. Law,
    • Marcy E. Litvak,
    • Nathaniel A. Brunsell,
    • Wouter Peters,
    • and Ingrid T. van der Laan-Luijkx
    PNAS 2016 113 (21) 5880-5885; published ahead of print April 25, 2016, doi:10.1073/pnas.1519620113
    See Commentary on page 5768 in issue 21 of volume 113

Corrections (Online Only)

  • Correction for Bourzac, News Feature: Liquid sunlight

    PNAS 2016 113 (21) E3048; published ahead of print May 24, 2016, doi:10.1073/pnas.1606805113

  • Correction for Ghan et al., Challenges in constraining anthropogenic aerosol effects on cloud radiative forcing using present-day spatiotemporal variability

    PNAS 2016 113 (21) E3049; published ahead of print April 18, 2016, doi:10.1073/pnas.1604888113

  • Correction for Buhrman et al., Quantum communication complexity advantage implies violation of a Bell inequality

    PNAS 2016 113 (21) E3050; published ahead of print May 16, 2016, doi:10.1073/pnas.1606259113

  • Correction for Bryant et al., Detecting affiliation in colaughter across 24 societies

    PNAS 2016 113 (21) E3051; published ahead of print May 16, 2016, doi:10.1073/pnas.1606204113