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Title:
Signal Transduction and the Control of Gene Expression
Authors:
Brivanlou, Ali H.; Darnell, James E.
Affiliation:
AA(Laboratory of Molecular Vertebrate Embryology,), AB(Laboratory of Molecular Cell Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.)
Publication:
Science, Volume 295, Issue 5556, pp. 813-818 (2002). (Sci Homepage)
Publication Date:
02/2002
Category:
MOLEC BIOL
Origin:
SCIENCE
Abstract Copyright:
(c) 2002: Science
DOI:
10.1126/science.1066355
Bibliographic Code:
2002Sci...295..813B

Abstract

More than 2000 transcription factors are encoded in the human genome. Such proteins have often been classified according to common structural elements. But because transcription factors evolved in the service of biologic function, we propose an alternative grouping of eukaryotic transcription factors on the basis of characteristics that describe their roles within cellular regulatory circuits.
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