• Research on the interactions between natural and social systems, and with how those interactions affect the challenge of sustainability.
  • Science Sessions: The PNAS Podcast Program

Cover
  • Open Access
  • From the Cover
  • Inaugural Article
  • Classic
  • Cozzarelli Prize Winner
  • Front Matter

This Week in PNAS

Letters (Online Only)

  • The “Atlantis Forest hypothesis” does not explain Atlantic Forest phylogeography

    • Fabio Raposo do Amaral,
    • Scott V. Edwards,
    • Marcio R. Pie,
    • W. Bryan Jennings,
    • Maria Svensson-Coelho,
    • Fernando M. d’Horta,
    • C. Jonathan Schmitt,
    • and Marcos Maldonado-Coelho
    PNAS 2016 113 (15) E2097-E2098; published ahead of print March 16, 2016, doi:10.1073/pnas.1602213113

  • Reply to Raposo do Amaral et al.: The “Atlantis Forest hypothesis” adds a new dimension to Atlantic Forest biogeography

    • Yuri L. R. Leite,
    • Leonora P. Costa,
    • Ana Carolina Loss,
    • Rita G. Rocha,
    • Henrique Batalha-Filho,
    • Alex C. Bastos,
    • Valéria S. Quaresma,
    • Valéria Fagundes,
    • Roberta Paresque,
    • Marcelo Passamani,
    • and Renata Pardini
    PNAS 2016 113 (15) E2099-E2100; published ahead of print March 16, 2016, doi:10.1073/pnas.1602391113

  • Benzoic acid is not the only important product of accelerated metabolism of cocaine

    • Stephen H. Curry and
    • Susan E. Coombs
    PNAS 2016 113 (15) E2101; published ahead of print March 22, 2016, doi:10.1073/pnas.1602305113

  • Reply to Curry and Coombs: Benzoic acid is formed predominantly from the benzoyl ester hydrolysis in the presence of cocaine hydrolase

    • Fang Zheng and
    • Chang-Guo Zhan
    PNAS 2016 113 (15) E2102-E2103; published ahead of print March 22, 2016, doi:10.1073/pnas.1602720113

Science and Culture

How science intersects with culture.

Core Concepts

A brief introduction to emerging topics in science.

QnAs

  • QnAs with Jan Svoboda

    • Brian Doctrow
    PNAS 2016 113 (15) 3910-3911; published ahead of print March 30, 2016, doi:10.1073/pnas.1603145113
    See Inaugural Article on page 3927 in issue 15 of volume 113

Commentaries

  • Evolutionary clash between myxoma virus and rabbit PKR in Australia

    • Hannah M. Burgess and
    • Ian Mohr
    PNAS 2016 113 (15) 3912-3914; published ahead of print March 31, 2016, doi:10.1073/pnas.1602063113
    See companion article on page 3855 in issue 14 of volume 113

  • Heterochromatin and genetic conflict

    • Colin D. Meiklejohn
    PNAS 2016 113 (15) 3915-3917; published ahead of print March 31, 2016, doi:10.1073/pnas.1603015113
    See companion article on page 4110 in issue 15 of volume 113

  • Enhanced gene targeting to evaluate Lynch syndrome alterations

    • Richard Fishel and
    • Christopher D. Heinen
    PNAS 2016 113 (15) 3918-3920; published ahead of print March 24, 2016, doi:10.1073/pnas.1602650113
    See companion articles on pages 4122 and 4128 in issue 15 of volume 113

  • Stress management strategies in single bacterial cells

    • Siv G. E. Andersson
    PNAS 2016 113 (15) 3921-3923; published ahead of print March 31, 2016, doi:10.1073/pnas.1603151113
    See companion article on page 4224 in issue 15 of volume 113

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

Physical Sciences

Applied Mathematics

  • Discovering governing equations from data by sparse identification of nonlinear dynamical systems

    • Steven L. Brunton,
    • Joshua L. Proctor,
    • and J. Nathan Kutz
    PNAS 2016 113 (15) 3932-3937; published ahead of print March 28, 2016, doi:10.1073/pnas.1517384113
    OPEN ACCESS ARTICLE

Applied Physical Sciences

  • Modulation of nitrogen vacancy charge state and fluorescence in nanodiamonds using electrochemical potential

    • Sinan Karaveli,
    • Ophir Gaathon,
    • Abraham Wolcott,
    • Reyu Sakakibara,
    • Or A. Shemesh,
    • Darcy S. Peterka,
    • Edward S. Boyden,
    • Jonathan S. Owen,
    • Rafael Yuste,
    • and Dirk Englund
    PNAS 2016 113 (15) 3938-3943; published ahead of print March 24, 2016, doi:10.1073/pnas.1504451113
    OPEN ACCESS ARTICLE

Astronomy

Chemistry

  • Self-assembly of crystalline nanotubes from monodisperse amphiphilic diblock copolypeptoid tiles

    • Jing Sun,
    • Xi Jiang,
    • Reidar Lund,
    • Kenneth H. Downing,
    • Nitash P. Balsara,
    • and Ronald N. Zuckermann
    PNAS 2016 113 (15) 3954-3959; published ahead of print March 28, 2016, doi:10.1073/pnas.1517169113

  • Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis

    • Kathrin Thell,
    • Roland Hellinger,
    • Emine Sahin,
    • Paul Michenthaler,
    • Markus Gold-Binder,
    • Thomas Haider,
    • Mario Kuttke,
    • Zita Liutkevičiūtė,
    • Ulf Göransson,
    • Carsten Gründemann,
    • Gernot Schabbauer,
    • and Christian W. Gruber
    PNAS 2016 113 (15) 3960-3965; published ahead of print March 28, 2016, doi:10.1073/pnas.1519960113
    OPEN ACCESS ARTICLE

  • Engineering titania nanostructure to tune and improve its photocatalytic activity

    • Matteo Cargnello,
    • Tiziano Montini,
    • Sergey Y. Smolin,
    • Jacqueline B. Priebe,
    • Juan J. Delgado Jaén,
    • Vicky V. T. Doan-Nguyen,
    • Ian S. McKay,
    • Jay A. Schwalbe,
    • Marga-Martina Pohl,
    • Thomas R. Gordon,
    • Yupeng Lu,
    • Jason B. Baxter,
    • Angelika Brückner,
    • Paolo Fornasiero,
    • and Christopher B. Murray
    PNAS 2016 113 (15) 3966-3971; published ahead of print March 28, 2016, doi:10.1073/pnas.1524806113

  • Ancient lipids document continuity in the use of early hunter–gatherer pottery through 9,000 years of Japanese prehistory

    • Alexandre Lucquin,
    • Kevin Gibbs,
    • Junzo Uchiyama,
    • Hayley Saul,
    • Mayumi Ajimoto,
    • Yvette Eley,
    • Anita Radini,
    • Carl P. Heron,
    • Shinya Shoda,
    • Yastami Nishida,
    • Jasmine Lundy,
    • Peter Jordan,
    • Sven Isaksson,
    • and Oliver E. Craig
    PNAS 2016 113 (15) 3991-3996; published ahead of print March 21, 2016, doi:10.1073/pnas.1522908113

  • Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery

    • Peng-Yu Yang,
    • Huafei Zou,
    • Elizabeth Chao,
    • Lance Sherwood,
    • Vanessa Nunez,
    • Michael Keeney,
    • Esi Ghartey-Tagoe,
    • Zhongli Ding,
    • Herlinda Quirino,
    • Xiaozhou Luo,
    • Gus Welzel,
    • Guohua Chen,
    • Parminder Singh,
    • Ashley K. Woods,
    • Peter G. Schultz,
    • and Weijun Shen
    PNAS 2016 113 (15) 4140-4145; published ahead of print March 28, 2016, doi:10.1073/pnas.1601653113
    OPEN ACCESS ARTICLE

Earth, Atmospheric, and Planetary Sciences

Engineering

  • Reporter nanoparticle that monitors its anticancer efficacy in real time

    • Ashish Kulkarni,
    • Poornima Rao,
    • Siva Natarajan,
    • Aaron Goldman,
    • Venkata S. Sabbisetti,
    • Yashika Khater,
    • Navya Korimerla,
    • Vineethkrishna Chandrasekar,
    • Raghunath A. Mashelkar,
    • and Shiladitya Sengupta
    PNAS 2016 113 (15) E2104-E2113; published ahead of print March 29, 2016, doi:10.1073/pnas.1603455113

  • Stokes trap for multiplexed particle manipulation and assembly using fluidics

    • Anish Shenoy,
    • Christopher V. Rao,
    • and Charles M. Schroeder
    PNAS 2016 113 (15) 3976-3981; published ahead of print March 28, 2016, doi:10.1073/pnas.1525162113

  • Artificial eye for scotopic vision with bioinspired all-optical photosensitivity enhancer

    • Hewei Liu,
    • Yinggang Huang,
    • and Hongrui Jiang
    PNAS 2016 113 (15) 3982-3985; published ahead of print March 14, 2016, doi:10.1073/pnas.1517953113
    OPEN ACCESS ARTICLE

  • Spatial patterns of cutaneous vibration during whole-hand haptic interactions

    • Yitian Shao,
    • Vincent Hayward,
    • and Yon Visell
    PNAS 2016 113 (15) 4188-4193; published ahead of print March 28, 2016, doi:10.1073/pnas.1520866113

Physics

Social Sciences

Anthropology

  • Ancient lipids document continuity in the use of early hunter–gatherer pottery through 9,000 years of Japanese prehistory

    • Alexandre Lucquin,
    • Kevin Gibbs,
    • Junzo Uchiyama,
    • Hayley Saul,
    • Mayumi Ajimoto,
    • Yvette Eley,
    • Anita Radini,
    • Carl P. Heron,
    • Shinya Shoda,
    • Yastami Nishida,
    • Jasmine Lundy,
    • Peter Jordan,
    • Sven Isaksson,
    • and Oliver E. Craig
    PNAS 2016 113 (15) 3991-3996; published ahead of print March 21, 2016, doi:10.1073/pnas.1522908113

  • Hunted gazelles evidence cooling, but not drying, during the Younger Dryas in the southern Levant

    • Gideon Hartman,
    • Ofer Bar-Yosef,
    • Alex Brittingham,
    • Leore Grosman,
    • and Natalie D. Munro
    PNAS 2016 113 (15) 3997-4002; published ahead of print March 28, 2016, doi:10.1073/pnas.1519862113

Economic Sciences

  • Testing theories of financial decision making

    • Christopher P. Chambers,
    • Federico Echenique,
    • and Kota Saito
    PNAS 2016 113 (15) 4003-4008; published ahead of print March 28, 2016, doi:10.1073/pnas.1517760113

Psychological and Cognitive Sciences

  • Dominant, open nonverbal displays are attractive at zero-acquaintance

    • Tanya Vacharkulksemsuk,
    • Emily Reit,
    • Poruz Khambatta,
    • Paul W. Eastwick,
    • Eli J. Finkel,
    • and Dana R. Carney
    PNAS 2016 113 (15) 4009-4014; published ahead of print March 28, 2016, doi:10.1073/pnas.1508932113

Social Sciences

  • Rise, stagnation, and rise of Danish women’s life expectancy

    • Rune Lindahl-Jacobsen,
    • Roland Rau,
    • Bernard Jeune,
    • Vladimir Canudas-Romo,
    • Adam Lenart,
    • Kaare Christensen,
    • and James W. Vaupel
    PNAS 2016 113 (15) 4015-4020; published ahead of print March 28, 2016, doi:10.1073/pnas.1602783113
    OPEN ACCESS ARTICLE

Sustainability Science

  • Land-use policies and corporate investments in agriculture in the Gran Chaco and Chiquitano

    • Yann le Polain de Waroux,
    • Rachael D. Garrett,
    • Robert Heilmayr,
    • and Eric F. Lambin
    PNAS 2016 113 (15) 4021-4026; published ahead of print March 28, 2016, doi:10.1073/pnas.1602646113
    OPEN ACCESS ARTICLE

  • Analysis and valuation of the health and climate change cobenefits of dietary change

    • Marco Springmann,
    • H. Charles J. Godfray,
    • Mike Rayner,
    • and Peter Scarborough
    PNAS 2016 113 (15) 4146-4151; published ahead of print March 21, 2016, doi:10.1073/pnas.1523119113
    OPEN ACCESS ARTICLE

Biological Sciences

Applied Biological Sciences

  • Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes

    • Andrew Brantley Hall,
    • Philippos-Aris Papathanos,
    • Atashi Sharma,
    • Changde Cheng,
    • Omar S. Akbari,
    • Lauren Assour,
    • Nicholas H. Bergman,
    • Alessia Cagnetti,
    • Andrea Crisanti,
    • Tania Dottorini,
    • Elisa Fiorentini,
    • Roberto Galizi,
    • Jonathan Hnath,
    • Xiaofang Jiang,
    • Sergey Koren,
    • Tony Nolan,
    • Diane Radune,
    • Maria V. Sharakhova,
    • Aaron Steele,
    • Vladimir A. Timoshevskiy,
    • Nikolai Windbichler,
    • Simo Zhang,
    • Matthew W. Hahn,
    • Adam M. Phillippy,
    • Scott J. Emrich,
    • Igor V. Sharakhov,
    • Zhijian Jake Tu,
    • and Nora J. Besansky
    PNAS 2016 113 (15) E2114-E2123; published ahead of print March 29, 2016, doi:10.1073/pnas.1525164113
    OPEN ACCESS ARTICLE

  • [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity

    • Woosuk Kim,
    • Thuc M. Le,
    • Liu Wei,
    • Soumya Poddar,
    • Jimmy Bazzy,
    • Xuemeng Wang,
    • Nhu T. Uong,
    • Evan R. Abt,
    • Joseph R. Capri,
    • Wayne R. Austin,
    • Juno S. Van Valkenburgh,
    • Dalton Steele,
    • Raymond M. Gipson,
    • Roger Slavik,
    • Anthony E. Cabebe,
    • Thotsophon Taechariyakul,
    • Shahriar S. Yaghoubi,
    • Jason T. Lee,
    • Saman Sadeghi,
    • Arnon Lavie,
    • Kym F. Faull,
    • Owen N. Witte,
    • Timothy R. Donahue,
    • Michael E. Phelps,
    • Harvey R. Herschman,
    • Ken Herrmann,
    • Johannes Czernin,
    • and Caius G. Radu
    PNAS 2016 113 (15) 4027-4032; published ahead of print March 28, 2016, doi:10.1073/pnas.1524212113

  • Invasive mammal eradication on islands results in substantial conservation gains

    • Holly P. Jones,
    • Nick D. Holmes,
    • Stuart H. M. Butchart,
    • Bernie R. Tershy,
    • Peter J. Kappes,
    • Ilse Corkery,
    • Alfonso Aguirre-Muñoz,
    • Doug P. Armstrong,
    • Elsa Bonnaud,
    • Andrew A. Burbidge,
    • Karl Campbell,
    • Franck Courchamp,
    • Philip E. Cowan,
    • Richard J. Cuthbert,
    • Steve Ebbert,
    • Piero Genovesi,
    • Gregg R. Howald,
    • Bradford S. Keitt,
    • Stephen W. Kress,
    • Colin M. Miskelly,
    • Steffen Oppel,
    • Sally Poncet,
    • Mark J. Rauzon,
    • Gérard Rocamora,
    • James C. Russell,
    • Araceli Samaniego-Herrera,
    • Philip J. Seddon,
    • Dena R. Spatz,
    • David R. Towns,
    • and Donald A. Croll
    PNAS 2016 113 (15) 4033-4038; published ahead of print March 21, 2016, doi:10.1073/pnas.1521179113
    OPEN ACCESS ARTICLE

Biochemistry

  • Genome-wide kinetics of DNA excision repair in relation to chromatin state and mutagenesis

    • Sheera Adar,
    • Jinchuan Hu,
    • Jason D. Lieb,
    • and Aziz Sancar
    PNAS 2016 113 (15) E2124-E2133; published ahead of print March 28, 2016, doi:10.1073/pnas.1603388113

  • Self-assembly of crystalline nanotubes from monodisperse amphiphilic diblock copolypeptoid tiles

    • Jing Sun,
    • Xi Jiang,
    • Reidar Lund,
    • Kenneth H. Downing,
    • Nitash P. Balsara,
    • and Ronald N. Zuckermann
    PNAS 2016 113 (15) 3954-3959; published ahead of print March 28, 2016, doi:10.1073/pnas.1517169113

  • Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

    • Benjamin Richter,
    • Danielle A. Sliter,
    • Lina Herhaus,
    • Alexandra Stolz,
    • Chunxin Wang,
    • Petra Beli,
    • Gabriele Zaffagnini,
    • Philipp Wild,
    • Sascha Martens,
    • Sebastian A. Wagner,
    • Richard J. Youle,
    • and Ivan Dikic
    PNAS 2016 113 (15) 4039-4044; published ahead of print March 30, 2016, doi:10.1073/pnas.1523926113

  • Host–parasite oscillation dynamics and evolution in a compartmentalized RNA replication system

    • Yohsuke Bansho,
    • Taro Furubayashi,
    • Norikazu Ichihashi,
    • and Tetsuya Yomo
    PNAS 2016 113 (15) 4045-4050; published ahead of print March 28, 2016, doi:10.1073/pnas.1524404113

  • Structures of E. coli σS-transcription initiation complexes provide new insights into polymerase mechanism

    • Bin Liu,
    • Yuhong Zuo,
    • and Thomas A. Steitz
    PNAS 2016 113 (15) 4051-4056; published ahead of print March 28, 2016, doi:10.1073/pnas.1520555113
    OPEN ACCESS ARTICLE

  • A bacterial Argonaute with noncanonical guide RNA specificity

    • Emine Kaya,
    • Kevin W. Doxzen,
    • Kilian R. Knoll,
    • Ross C. Wilson,
    • Steven C. Strutt,
    • Philip J. Kranzusch,
    • and Jennifer A. Doudna
    PNAS 2016 113 (15) 4057-4062; published ahead of print March 30, 2016, doi:10.1073/pnas.1524385113
    OPEN ACCESS ARTICLE

Biophysics and Computational Biology

  • Stokes trap for multiplexed particle manipulation and assembly using fluidics

    • Anish Shenoy,
    • Christopher V. Rao,
    • and Charles M. Schroeder
    PNAS 2016 113 (15) 3976-3981; published ahead of print March 28, 2016, doi:10.1073/pnas.1525162113

  • Discrete gene replication events drive coupling between the cell cycle and circadian clocks

    • Joris Paijmans,
    • Mark Bosman,
    • Pieter Rein ten Wolde,
    • and David K. Lubensky
    PNAS 2016 113 (15) 4063-4068; published ahead of print March 28, 2016, doi:10.1073/pnas.1507291113
    OPEN ACCESS ARTICLE

  • Measuring and modeling diffuse scattering in protein X-ray crystallography

    • Andrew H. Van Benschoten,
    • Lin Liu,
    • Ana Gonzalez,
    • Aaron S. Brewster,
    • Nicholas K. Sauter,
    • James S. Fraser,
    • and Michael E. Wall
    PNAS 2016 113 (15) 4069-4074; published ahead of print March 28, 2016, doi:10.1073/pnas.1524048113
    OPEN ACCESS ARTICLE

Cell Biology

  • Modeling and analysis of collective cell migration in an in vivo three-dimensional environment

    • Danfeng Cai,
    • Wei Dai,
    • Mohit Prasad,
    • Junjie Luo,
    • Nir S. Gov,
    • and Denise J. Montell
    PNAS 2016 113 (15) E2134-E2141; published ahead of print March 29, 2016, doi:10.1073/pnas.1522656113

  • On board a raft or boat in the retrovirus sea

    • Jan Svoboda
    PNAS 2016 113 (15) 3927-3931; published ahead of print March 30, 2016, doi:10.1073/pnas.1602317113
    See QnAs on page 3910 in issue 15 of volume 113

  • CRF binding protein facilitates the presence of CRF type 2α receptor on the cell surface

    • Paula G. Slater,
    • Cledi A. Cerda,
    • Luis A. Pereira,
    • María E. Andrés,
    • and Katia Gysling
    PNAS 2016 113 (15) 4075-4080; published ahead of print March 28, 2016, doi:10.1073/pnas.1523745113

Ecology

  • Invasive species triggers a massive loss of ecosystem services through a trophic cascade

    • Jake R. Walsh,
    • Stephen R. Carpenter,
    • and M. Jake Vander Zanden
    PNAS 2016 113 (15) 4081-4085; published ahead of print March 21, 2016, doi:10.1073/pnas.1600366113

  • Conditional vulnerability of plant diversity to atmospheric nitrogen deposition across the United States

    • Samuel M. Simkin,
    • Edith B. Allen,
    • William D. Bowman,
    • Christopher M. Clark,
    • Jayne Belnap,
    • Matthew L. Brooks,
    • Brian S. Cade,
    • Scott L. Collins,
    • Linda H. Geiser,
    • Frank S. Gilliam,
    • Sarah E. Jovan,
    • Linda H. Pardo,
    • Bethany K. Schulz,
    • Carly J. Stevens,
    • Katharine N. Suding,
    • Heather L. Throop,
    • and Donald M. Waller
    PNAS 2016 113 (15) 4086-4091; published ahead of print March 28, 2016, doi:10.1073/pnas.1515241113

  • Differential and enhanced response to climate forcing in diarrheal disease due to rotavirus across a megacity of the developing world

    • Pamela P. Martinez,
    • Aaron A. King,
    • Mohammad Yunus,
    • A. S. G. Faruque,
    • and Mercedes Pascual
    PNAS 2016 113 (15) 4092-4097; published ahead of print March 28, 2016, doi:10.1073/pnas.1518977113
    OPEN ACCESS ARTICLE

  • Legumes are different: Leaf nitrogen, photosynthesis, and water use efficiency

    • Mark Andrew Adams,
    • Tarryn L. Turnbull,
    • Janet I. Sprent,
    • and Nina Buchmann
    PNAS 2016 113 (15) 4098-4103; published ahead of print March 30, 2016, doi:10.1073/pnas.1523936113
    OPEN ACCESS ARTICLE

  • Predation risk drives social complexity in cooperative breeders

    • Frank Groenewoud,
    • Joachim Gerhard Frommen,
    • Dario Josi,
    • Hirokazu Tanaka,
    • Arne Jungwirth,
    • and Michael Taborsky
    PNAS 2016 113 (15) 4104-4109; published ahead of print March 28, 2016, doi:10.1073/pnas.1524178113

Evolution

  • Rapid evolution of a Y-chromosome heterochromatin protein underlies sex chromosome meiotic drive

    • Quentin Helleu,
    • Pierre R. Gérard,
    • Raphaëlle Dubruille,
    • David Ogereau,
    • Benjamin Prud’homme,
    • Benjamin Loppin,
    • and Catherine Montchamp-Moreau
    PNAS 2016 113 (15) 4110-4115; published ahead of print March 15, 2016, doi:10.1073/pnas.1519332113
    See Commentary on page 3915 in issue 15 of volume 113

  • Horizontally acquired genes in early-diverging pathogenic fungi enable the use of host nucleosides and nucleotides

    • William G. Alexander,
    • Jennifer H. Wisecaver,
    • Antonis Rokas,
    • and Chris Todd Hittinger
    PNAS 2016 113 (15) 4116-4121; published ahead of print March 29, 2016, doi:10.1073/pnas.1517242113

Genetics

  • LNA modification of single-stranded DNA oligonucleotides allows subtle gene modification in mismatch-repair-proficient cells

    • Thomas W. van Ravesteyn,
    • Marleen Dekker,
    • Alexander Fish,
    • Titia K. Sixma,
    • Astrid Wolters,
    • Rob J. Dekker,
    • and Hein P. J. te Riele
    PNAS 2016 113 (15) 4122-4127; published ahead of print March 7, 2016, doi:10.1073/pnas.1513315113
    See Commentary on page 3918 in issue 15 of volume 113

  • Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants

    • Hellen Houlleberghs,
    • Marleen Dekker,
    • Hildo Lantermans,
    • Roos Kleinendorst,
    • Hendrikus Jan Dubbink,
    • Robert M. W. Hofstra,
    • Senno Verhoef,
    • and Hein te Riele
    PNAS 2016 113 (15) 4128-4133; published ahead of print March 7, 2016, doi:10.1073/pnas.1520813113
    See Commentary on page 3918 in issue 15 of volume 113

  • Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans

    • Hao Wu,
    • Liwei Sun,
    • Yang Wen,
    • Yujuan Liu,
    • Jun Yu,
    • Feiyu Mao,
    • Ya Wang,
    • Chao Tong,
    • Xuejiang Guo,
    • Zhibin Hu,
    • Jiahao Sha,
    • Mingxi Liu,
    • and Laixin Xia
    PNAS 2016 113 (15) 4134-4139; published ahead of print March 28, 2016, doi:10.1073/pnas.1513682113

Immunology and Inflammation

  • Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus

    • Andrew J. Monteith,
    • SunAh Kang,
    • Eric Scott,
    • Kai Hillman,
    • Zenon Rajfur,
    • Ken Jacobson,
    • M. Joseph Costello,
    • and Barbara J. Vilen
    PNAS 2016 113 (15) E2142-E2151; published ahead of print March 28, 2016, doi:10.1073/pnas.1513943113

  • Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis

    • Kathrin Thell,
    • Roland Hellinger,
    • Emine Sahin,
    • Paul Michenthaler,
    • Markus Gold-Binder,
    • Thomas Haider,
    • Mario Kuttke,
    • Zita Liutkevičiūtė,
    • Ulf Göransson,
    • Carsten Gründemann,
    • Gernot Schabbauer,
    • and Christian W. Gruber
    PNAS 2016 113 (15) 3960-3965; published ahead of print March 28, 2016, doi:10.1073/pnas.1519960113
    OPEN ACCESS ARTICLE

Medical Sciences

  • Reporter nanoparticle that monitors its anticancer efficacy in real time

    • Ashish Kulkarni,
    • Poornima Rao,
    • Siva Natarajan,
    • Aaron Goldman,
    • Venkata S. Sabbisetti,
    • Yashika Khater,
    • Navya Korimerla,
    • Vineethkrishna Chandrasekar,
    • Raghunath A. Mashelkar,
    • and Shiladitya Sengupta
    PNAS 2016 113 (15) E2104-E2113; published ahead of print March 29, 2016, doi:10.1073/pnas.1603455113

  • Anabolic actions of Notch on mature bone

    • Peng Liu,
    • Yilin Ping,
    • Meng Ma,
    • Demao Zhang,
    • Connie Liu,
    • Samir Zaidi,
    • Song Gao,
    • Yaoting Ji,
    • Feng Lou,
    • Fanyuan Yu,
    • Ping Lu,
    • Agnes Stachnik,
    • Mingru Bai,
    • Chengguo Wei,
    • Liaoran Zhang,
    • Ke Wang,
    • Rong Chen,
    • Maria I. New,
    • David W. Rowe,
    • Tony Yuen,
    • Li Sun,
    • and Mone Zaidi
    PNAS 2016 113 (15) E2152-E2161; published ahead of print March 28, 2016, doi:10.1073/pnas.1603399113

  • Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers

    • Lin-ting Hsia,
    • Neil Ashley,
    • Djamila Ouaret,
    • Lai Mun Wang,
    • Jennifer Wilding,
    • and Walter F. Bodmer
    PNAS 2016 113 (15) E2162-E2171; published ahead of print March 28, 2016, doi:10.1073/pnas.1603534113

  • Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery

    • Peng-Yu Yang,
    • Huafei Zou,
    • Elizabeth Chao,
    • Lance Sherwood,
    • Vanessa Nunez,
    • Michael Keeney,
    • Esi Ghartey-Tagoe,
    • Zhongli Ding,
    • Herlinda Quirino,
    • Xiaozhou Luo,
    • Gus Welzel,
    • Guohua Chen,
    • Parminder Singh,
    • Ashley K. Woods,
    • Peter G. Schultz,
    • and Weijun Shen
    PNAS 2016 113 (15) 4140-4145; published ahead of print March 28, 2016, doi:10.1073/pnas.1601653113
    OPEN ACCESS ARTICLE

  • Analysis and valuation of the health and climate change cobenefits of dietary change

    • Marco Springmann,
    • H. Charles J. Godfray,
    • Mike Rayner,
    • and Peter Scarborough
    PNAS 2016 113 (15) 4146-4151; published ahead of print March 21, 2016, doi:10.1073/pnas.1523119113
    OPEN ACCESS ARTICLE

  • S-nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration

    • Uthpala Seneviratne,
    • Alexi Nott,
    • Vadiraja B. Bhat,
    • Kodihalli C. Ravindra,
    • John S. Wishnok,
    • Li-Huei Tsai,
    • and Steven R. Tannenbaum
    PNAS 2016 113 (15) 4152-4157; published ahead of print March 24, 2016, doi:10.1073/pnas.1521318113
    OPEN ACCESS ARTICLE

  • Endocrine vasculatures are preferable targets of an antitumor ineffective low dose of anti-VEGF therapy

    • Yin Zhang,
    • Yunlong Yang,
    • Kayoko Hosaka,
    • Guichun Huang,
    • Jingwu Zang,
    • Fang Chen,
    • Yun Zhang,
    • Nilesh J. Samani,
    • and Yihai Cao
    PNAS 2016 113 (15) 4158-4163; published ahead of print March 28, 2016, doi:10.1073/pnas.1601649113

  • Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy

    • Hong-Jun Li,
    • Jin-Zhi Du,
    • Xiao-Jiao Du,
    • Cong-Fei Xu,
    • Chun-Yang Sun,
    • Hong-Xia Wang,
    • Zhi-Ting Cao,
    • Xian-Zhu Yang,
    • Yan-Hua Zhu,
    • Shuming Nie,
    • and Jun Wang
    PNAS 2016 113 (15) 4164-4169; published ahead of print March 28, 2016, doi:10.1073/pnas.1522080113

Microbiology

  • Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model

    • Aleidy Silva,
    • Bai-Yu Lee,
    • Daniel L. Clemens,
    • Theodore Kee,
    • Xianting Ding,
    • Chih-Ming Ho,
    • and Marcus A. Horwitz
    PNAS 2016 113 (15) E2172-E2179; published ahead of print March 28, 2016, doi:10.1073/pnas.1600812113

  • Virological factors that increase the transmissibility of emerging human viruses

    • Jemma L. Geoghegan,
    • Alistair M. Senior,
    • Francesca Di Giallonardo,
    • and Edward C. Holmes
    PNAS 2016 113 (15) 4170-4175; published ahead of print March 21, 2016, doi:10.1073/pnas.1521582113

  • Two distinct trimeric conformations of natively membrane-anchored full-length herpes simplex virus 1 glycoprotein B

    • Tzviya Zeev-Ben-Mordehai,
    • Daven Vasishtan,
    • Anna Hernández Durán,
    • Benjamin Vollmer,
    • Paul White,
    • Arun Prasad Pandurangan,
    • C. Alistair Siebert,
    • Maya Topf,
    • and Kay Grünewald
    PNAS 2016 113 (15) 4176-4181; published ahead of print March 24, 2016, doi:10.1073/pnas.1523234113

  • Comprehensive mutagenesis of the fimS promoter regulatory switch reveals novel regulation of type 1 pili in uropathogenic Escherichia coli

    • Huibin Zhang,
    • Teodorus T. Susanto,
    • Yue Wan,
    • and Swaine L. Chen
    PNAS 2016 113 (15) 4182-4187; published ahead of print March 30, 2016, doi:10.1073/pnas.1522958113
    OPEN ACCESS ARTICLE

Neuroscience

  • Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism

    • Paul D. Dodson,
    • Jakob K. Dreyer,
    • Katie A. Jennings,
    • Emilie C. J. Syed,
    • Richard Wade-Martins,
    • Stephanie J. Cragg,
    • J. Paul Bolam,
    • and Peter J. Magill
    PNAS 2016 113 (15) E2180-E2188; published ahead of print March 21, 2016, doi:10.1073/pnas.1515941113

  • Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish

    • Thomas S. Lisse,
    • Leah J. Middleton,
    • Adriana D. Pellegrini,
    • Paige B. Martin,
    • Emily L. Spaulding,
    • Olivia Lopes,
    • Elizabeth A. Brochu,
    • Erin V. Carter,
    • Ashley Waldron,
    • and Sandra Rieger
    PNAS 2016 113 (15) E2189-E2198; published ahead of print March 28, 2016, doi:10.1073/pnas.1525096113
    OPEN ACCESS ARTICLE

  • Spatial patterns of cutaneous vibration during whole-hand haptic interactions

    • Yitian Shao,
    • Vincent Hayward,
    • and Yon Visell
    PNAS 2016 113 (15) 4188-4193; published ahead of print March 28, 2016, doi:10.1073/pnas.1520866113

  • Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels

    • Joshua Levitz,
    • Perrine Royal,
    • Yannick Comoglio,
    • Brigitte Wdziekonski,
    • Sébastien Schaub,
    • Daniel M. Clemens,
    • Ehud Y. Isacoff,
    • and Guillaume Sandoz
    PNAS 2016 113 (15) 4194-4199; published ahead of print March 28, 2016, doi:10.1073/pnas.1522459113

  • Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties

    • Sandy Blin,
    • Ismail Ben Soussia,
    • Eun-Jin Kim,
    • Frédéric Brau,
    • Dawon Kang,
    • Florian Lesage,
    • and Delphine Bichet
    PNAS 2016 113 (15) 4200-4205; published ahead of print March 28, 2016, doi:10.1073/pnas.1522748113

  • Dopamine synapse is a neuroligin-2–mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures

    • Motokazu Uchigashima,
    • Toshihisa Ohtsuka,
    • Kazuto Kobayashi,
    • and Masahiko Watanabe
    PNAS 2016 113 (15) 4206-4211; published ahead of print March 25, 2016, doi:10.1073/pnas.1514074113

Physiology

  • Rethinking progesterone regulation of female reproductive cyclicity

    • Kaiyu Kubota,
    • Wei Cui,
    • Pramod Dhakal,
    • Michael W. Wolfe,
    • M. A. Karim Rumi,
    • Jay L. Vivian,
    • Katherine F. Roby,
    • and Michael J. Soares
    PNAS 2016 113 (15) 4212-4217; published ahead of print March 28, 2016, doi:10.1073/pnas.1601825113

Plant Biology

  • DELAY OF GERMINATION1 (DOG1) regulates both seed dormancy and flowering time through microRNA pathways

    • Heqiang Huo,
    • Shouhui Wei,
    • and Kent J. Bradford
    PNAS 2016 113 (15) E2199-E2206; published ahead of print March 28, 2016, doi:10.1073/pnas.1600558113

  • GOLDEN 2-LIKE transcription factors for chloroplast development affect ozone tolerance through the regulation of stomatal movement

    • Yukari Nagatoshi,
    • Nobutaka Mitsuda,
    • Maki Hayashi,
    • Shin-ichiro Inoue,
    • Eiji Okuma,
    • Akihiro Kubo,
    • Yoshiyuki Murata,
    • Mitsunori Seo,
    • Hikaru Saji,
    • Toshinori Kinoshita,
    • and Masaru Ohme-Takagi
    PNAS 2016 113 (15) 4218-4223; published ahead of print March 28, 2016, doi:10.1073/pnas.1513093113

Population Biology

  • Response of single bacterial cells to stress gives rise to complex history dependence at the population level

    • Roland Mathis and
    • Martin Ackermann
    PNAS 2016 113 (15) 4224-4229; published ahead of print March 9, 2016, doi:10.1073/pnas.1511509113
    OPEN ACCESS ARTICLE
    See Commentary on page 3921 in issue 15 of volume 113

Correction (Online Only)

  • Correction for Fukuda et al., Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography

    PNAS 2016 113 (15) E2207; published ahead of print March 28, 2016, doi:10.1073/pnas.1604061113

Retraction (Online Only)

  • Retraction for Dong et al., Deficient Smad7 expression: A putative molecular defect in scleroderma

    PNAS 2016 113 (15) E2208; published ahead of print April 4, 2016, doi:10.1073/pnas.1603558113