Contents
12 April 2016
Vol 9, Issue 423
Vol 9, Issue 423
Contents
Editorial Guide
- Focus Issue: New insights in GPCR to G protein signaling
Complexity in how G proteins and their receptors signal continues to emerge.
Research Articles
- Metalloprotease cleavage of the N terminus of the orphan G protein–coupled receptor GPR37L1 reduces its constitutive activity
The N terminus of the receptor GPR37L1 enables constitutive signaling to Gαs.
- Dominant-negative Gα subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease
Mutations in the G protein subunit Gαi3 prevent the endothelin receptor from coupling to the appropriate G protein in patients with auriculo-condylar syndrome.
- Gβ promotes pheromone receptor polarization and yeast chemotropism by inhibiting receptor phosphorylation
The Gβ subunit promotes mating responses in yeast by keeping pheromone receptors at the cell surface.
Podcast
- Science Signaling Podcast for 12 April 2016: G proteins in auriculo-condylar syndrome
Mutations that cause a GPCR to couple to the wrong G protein cause auriculo-condylar syndrome.
Editors' Choice
- PTEN as a tumor promoter
Because it enhances the survival of pre-B cells, PTEN could be targeted to treat pre-B acute lymphoblastic leukemia.
- Repurposing an HIV drug for melanoma
The HIV drug nelfinavir overcomes resistance to BRAF and MEK inhibitors in melanoma.
- Spatially restricting caspase activation
A Krebs cycle protein enables the caspase-dependent elimination of spermatid mitochondria without killing the cell.
- Papers of note in Science
This week’s articles show that macrophages can protect lymph nodes from tumor-secreted vesicles, expression of the oncogene MYC helps cancer cells evade the immune response, and bacteria can use riboswitches to defend themselves against antibiotics.
- Papers of note in Science Translational Medicine
This week’s articles describe why androgen receptors may fail to prevent relapsing prostate cancer, a more physiologically relevant way to study neurotoxicity, and how cyclodextrin causes macrophages to rid blood vessels of cholesterol plaques.
About The Cover
Online Cover This week features a Focus Issue that highlights new insights in G protein–coupled receptor (GPCR) to G protein signaling. The image shows the GPCR-activated G protein cycle. [Image: Preininger and Hamm/Sci. STKE]
