DMM invites submissions for a Special Collection on Neurodegenerative Diseases, guest edited by Aaron Gitler and James Shorter. Click here for more information.
DEADLINE EXTENDED TO SEPTEMBER 30th 2016
current issue Vol 9/ Issue 8
Disease Models & Mechanisms (DMM) is an online Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.
The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science, and the journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Monica Justice and Ross Cagan, and the journal is supported by an outstanding Editorial Advisory Board.
Research Highlights
Editors' choice:
A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition.
In vivo validation of a potent DYRK1A inhibitor, with proven clinical safety, using Down-syndrome- and Alzheimer's-disease-like models.
Other highlights:
Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma
Zebrafish with an inactivating mutation in the vhl gene can be used as a model of early stage clear cell renal cell carcinoma, with applications for genetic studies and drug screens.
Alterations in nuclear structure promote lupus autoimmunity in a mouse model
Combining a disruption in nuclear structure with a lupus-prone genetic background induces autoimmunity, suggesting that nuclear alterations trigger the disease in genetically susceptible individuals.
Protein Misfolding Diseases
In a new Special Article, Brehme and Voisine perform a comprehensive literature survey that highlights the power of model systems to unveil key chaperone modifiers of proteotoxicity with potential therapeutic applications. Read the article in full.
In a related article, Harm Kampinga and colleagues summarize the literature on a set of aggregation diseases and propose that each of them can be characterized or ‘barcoded’ by a different set of HSPs that can rescue specific types of aggregation.
Call for Papers
DEADLINE EXTENDED TO SEPTEMBER 30th 2016
Highlighted articles
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Mylène Hervé, El Chérif Ibrahim
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Namrata Singh, Duncan B. Johnstone, Kayla A. Martin, Italo Tempera, Mariana J. Kaplan, Michael F. Denny
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Haley R. Noonan, Ana M. Metelo, Caramai N. Kamei, Randall T. Peterson, Iain A. Drummond, Othon Iliopoulos
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K. Saidas Nair, Mihai Cosma, Narayanan Raghupathy, Michael A. Sellarole, Nicholas G. Tolman, Wilhelmine de Vries, Richard S. Smith, Simon W. M. John
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Vanessa B. Martino, Thomas Sabljic, Paula Deschamps, Rebecca M. Green, Monica Akula, Erica Peacock, Alexander Ball, Trevor Williams, Judith A. West-Mays
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Hyeongki Kim, Kyu-Sun Lee, Ae-Kyeong Kim, Miri Choi, Kwangman Choi, Mingu Kang, Seung-Wook Chi, Min-Sung Lee, Jeong-Soo Lee, So-Young Lee, Woo-Joo Song, Kweon Yu, Sungchan Cho
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Marc Brehme, Cindy Voisine
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Leonard Zon
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Dido Carrero, Clara Soria-Valles, Carlos López-Otín
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Madalena C. Carneiro, Inês Pimenta de Castro, Miguel Godinho Ferreira
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Adam D. Pfefferle, Yash N. Agrawal, Daniel C. Koboldt, Krishna L. Kanchi, Jason I. Herschkowitz, Elaine R. Mardis, Jeffrey M. Rosen, Charles M. Perou