George O'Connor | Profiles RNS

George T. O'Connor, MD

Professor

Boston University Chobanian & Avedisian School of Medicine

Dept of Medicine

Pulmonary, Allergy, Sleep & Critical Care Medicine

MD, Boston University School of Medicine
MS, Harvard School of Public Health

Websites

	Boston Medical Center Provider Profile
	Pulmonary, Allergy, Sleep & Critical Care Medicine Faculty
	College of Engineering Faculty
	Public Relations - BU Experts

ORCID : 0000-0002-6476-3926

My research focuses on epidemiology, including genetic epidemiology, and clinical investigations of asthma, allergy, chronic obstructive pulmonary disease, and sleep apnea. I have been the Boston University / Boston Medical Center principal investigator of multiple NIH-funded multi-center investigations, currently including the Inner-City Asthma Consortium (ICAC), the Vitamin D Antenatal Asthma Reduction Trial (VDAART), and the All of Us Research Program. Our ICAC studies include clinical trials in children and adolescents with asthma and a birth-cohort study examining the risk factors for asthma and allergy in the inner city. I also conduct epidemiologic and genetic epidemiologic research at the Framingham Heart Study, including genome-wide association studies seeking novel genetic determinants of lung function impairment, interstitial lung abnormalities, and atopy. I have collaborated with the Division of Computational Biomedicine's studies of alterations in gene expression related to tobacco smoking and COPD. My research spans disciplines including adult medicine, pediatrics, obstetrics, epidemiology, genetics and genomics, immunology, and environmental science. At Boston Medical Center, my outpatient practice focuses on adults with asthma, COPD, and bronchiectasis. I am an Associate Editor of JAMA.

Ad-interim Director; Co-Principle Investigator
Framingham Heart Study

Member
Boston University
Pulmonary Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Member
Boston University
Genome Science Institute

Clinical Center for NIH's Nurtrition for Precision Health: The All of Us NEw England Research Collaborative
12/10/2021 - 11/30/2026 (Subcontract PI)
Trustees of Tufts College, Inc NIH NICHD
1UG1HD107691-01

The Boston University Clinical and Transitional Science Institute
04/15/2020 - 03/31/2025 (Key Person)
PI: Megan H. Bair-Merritt, MD, MSCE
NIH/National Center for Advancing Translational Sciences
3UL1TR001430-07S1

Multi-Omic Approaches To Mechanisms Of Vitamin D, Environmental Influences, And The Microbiome On Asthma
09/01/2018 - 08/31/2023 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH OD
5UH3OD023268-06

Childrens Respiratory and Environmental Workgroup (CREW)
09/01/2018 - 08/31/2023 (Subcontract PI)
University of Wisconsin System NIH OD
5UH3OD023282-07

Interstitial Lung Abnormalities: Defining the Phenotype, Causes, and Consequences
05/01/2019 - 04/30/2023 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL111024-09

Framingham Heart Study
04/01/2019 - 04/30/2023 (Multi-PI)
PI: George T. O'Connor, MD
NIH/National Heart, Lung, and Blood Institute
75N92019D00031

Childhood Asthma in Urban Settings (CAUSE)- Leadership Center
08/01/2021 - 03/31/2023 (Subcontract PI)
University of Wisconsin, Madison NIH NIAID
5UM1AI160040-02

The New England Precision Medicine Consortium of the All of Us Research Program
03/01/2019 - 02/28/2023 (Subcontract PI)
Massachusetts General Hospital NIH OD
3OT2OD026553-01S4

Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung Abnormalities
08/01/2018 - 07/31/2021 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5R01HL135142-04

Inner City Asthma Consortium 3 (ICAC3)
08/01/2016 - 07/31/2021 (Subcontract PI)
University of Wisconsin System NIH NIAID
3UM1AI114271-07S1

Showing 10 of 38 results. Show All Results

The New England Precision Medicine Consortium of the All of_
03/01/2018 - 02/28/2023 (PI)
The General Hospital Corporation / MGH National Institutes

A New England Enrollment Center for the PMI Cohort Program
04/01/2017 - 02/28/2018 (PI)
Mass General Hosp NIH-OD

ScreenFlow - COPD Screening System
09/30/2014 - 09/29/2016 (PI)
Dimagi, Inc. NIH-DHHS

ScreenFlow - COPD Screening System
07/01/2012 - 11/07/2013 (PI)
Dimagi, Inc. NIH-NHLBI

Screen Flow Development - Research Assistance
12/21/2012 - 05/31/2013 (PI)
Dimagi, Inc.

Title

Yr	Title	Project-Sub Proj	Pubs
2022	The New England Precision Medicine Consortium of the All of Us Research Program	3OT2OD026553-01S4
2021	The New England Precision Medicine Consortium of the All of Us Research Program	3OT2OD026553-01S3	3
2020	The New England Precision Medicine Consortium of the All of Us Research Program	3OT2OD026553-01S2	3
2019	The New England Precision Medicine Consortium of the All of Us Research Program	3OT2OD026553-01S1	3
2018	The New England Precision Medicine Consortium of the All of Us Research Program	1OT2OD026553-01	3
2017	A New England Enrollment Center for PMI Cohort Program	3OT2OD024612-01S1
2016	A New England Enrollment Center for PMI Cohort Program	1OT2OD024612-01
2013	Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype	5R01HL101390-04	3
2012	Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype	5R01HL101390-03	3
2011	Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype	5R01HL101390-02	3

Showing 10 of 74 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Kim W, Hecker J, Barr RG, Boerwinkle E, Cade B, Correa A, Dupuis J, Gharib SA, Lange L, London SJ, Morrison AC, O'Connor GT, Oelsner EC, Psaty BM, Vasan RS, Redline S, Rich SS, Rotter JI, Yu B, Lange C, Manichaikul A, Zhou JJ, Sofer T, Silverman EK, Qiao D, Cho MH. Assessing the contribution of rare genetic variants to phenotypes of chronic obstructive pulmonary disease using whole-genome sequence data. Hum Mol Genet. 2022 Nov 10; 31(22):3873-3885.View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 35766891; PMCID: PMC9652112; DOI: 10.1093/hmg/ddac117;

Zhang J, Xu H, Qiao D, DeMeo DL, Silverman EK, O'Connor GT, Hobbs BD, Dupuis J, Cho MH, Moll M. A polygenic risk score and age of diagnosis of COPD. Eur Respir J. 2022 Sep; 60(3).View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 35115341

Putman RK, Axelsson GT, Ash SY, Sanders JL, Menon AA, Araki T, Nishino M, Yanagawa M, Gudmundsson EF, Qiao D, San José Estépar R, Dupuis J, O'Connor GT, Rosas IO, Washko GR, El-Chemaly S, Raby BA, Gudnason V, DeMeo DL, Silverman EK, Hatabu H, DeVivo I, Cho MH, Gudmundsson G, Hunninghake GM. Interstitial lung abnormalities are associated with decreased mean telomere length. Eur Respir J. 2022 Aug; 60(2).View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 35115336

McNeill J, Chernofsky A, Nayor M, Rahaghi FN, San Jose Estepar R, Washko G, Synn A, Vasan RS, O'Connor G, Larson MG, Ho JE, Lewis GD. The association of lung function and pulmonary vasculature volume with cardiorespiratory fitness in the community. Eur Respir J. 2022 Aug; 60(2).View Related Profiles.

O'Connor, George
Larson, Martin
Nayor, Matthew

PMID: 34996832; PMCID: PMC9259762; DOI: 10.1183/13993003.01821-2021;

Bhatt SP, Balte PP, Schwartz JE, Jaeger BC, Cassano PA, Chaves PH, Couper D, Jacobs DR, Kalhan R, Kaplan R, Lloyd-Jones D, Newman AB, O'Connor G, Sanders JL, Smith BM, Sun Y, Umans JG, White WB, Yende S, Oelsner EC. Pooled Cohort Probability Score for Subclinical Airflow Obstruction. Ann Am Thorac Soc. 2022 Aug; 19(8):1294-1304. PMID: 35176216; PMCID: PMC9353954; DOI: 10.1513/AnnalsATS.202109-1020OC;

Sanders JL, Axelsson G, Putman R, Menon A, Dupuis J, Xu H, Wang S, Murabito J, Vasan R, Araki T, Nishino M, Washko GR, Hatabu H, O'Connor G, Gudmundsson G, Gudnason V, Hunninghake GM. The relationship between interstitial lung abnormalities, mortality, and multimorbidity: a cohort study. Thorax. 2022 Jul 01.View Related Profiles.

O'Connor, George
Murabito, Joanne
Dupuis, Josee

PMID: 35777957

Gereige JD, Xu H, Ortega VE, Cho MH, Liu M, Sakornsakolpat P, Silverman EK, Beaty TH, Miller BE, Bakke P, Gulsvik A, Hersh CP, Morrow JD, Ampleford EJ, Hawkins GA, Bleecker ER, Meyers DA, Peters SP, Celedón JC, Tantisira K, Li J, Dupuis J, O'Connor GT. A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts. ERJ Open Res. 2022 Apr; 8(2).View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 35769418; PMCID: PMC9234425; DOI: 10.1183/23120541.00484-2021;

Eckhardt CM, Balte PP, Barr RG, Bertoni AG, Bhatt SP, Cuttica M, Cassano PA, Chaves P, Couper D, Jacobs DR, Kalhan R, Kronmal R, Lange L, Loehr L, London SJ, O'Connor GT, Rosamond W, Sanders J, Schwartz JE, Shah A, Shah SJ, Smith L, White W, Yende S, Oelsner EC. Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study. Eur Heart J. 2022 Jun 14; 43(23):2196-2208. PMID: 35467708; PMCID: PMC9631233; DOI: 10.1093/eurheartj/ehac205;

Seibold MA, Moore CM, Everman JL, Williams BJM, Nolin JD, Fairbanks-Mahnke A, Plender EG, Patel BB, Arbes SJ, Bacharier LB, Bendixsen CG, Calatroni A, Camargo CA, Dupont WD, Furuta GT, Gebretsadik T, Gruchalla RS, Gupta RS, Khurana Hershey GK, Murrison LB, Jackson DJ, Johnson CC, Kattan M, Liu AH, Lussier SJ, O'Connor GT, Rivera-Spoljaric K, Phipatanakul W, Rothenberg ME, Seroogy CM, Teach SJ, Zoratti EM, Togias A, Fulkerson PC, Hartert TV. Risk factors for SARS-CoV-2 infection and transmission in households with children with asthma and allergy: A prospective surveillance study. J Allergy Clin Immunol. 2022 Aug; 150(2):302-311. PMID: 35660376; PMCID: PMC9155183; DOI: 10.1016/j.jaci.2022.05.014;

Bhatt SP, O'Connor GT. Screening for Chronic Obstructive Pulmonary Disease: Challenges and Opportunities. JAMA. 2022 05 10; 327(18):1768-1770. PMID: 35536275

Showing 10 of 303 results. Show More

McNeill JN, Lee DH, Hwang SJ, Courchesne P, Yao C, Huan T, Joehanes R, O'Connor GT, Ho JE, Levy D. Association of 71 cardiovascular disease-related plasma proteins with pulmonary function in the community. PLoS One. 2022; 17(4):e0266523.View Related Profiles.

O'Connor, George
Hwang, Shih-Jen

PMID: 35390066; PMCID: PMC8989231; DOI: 10.1371/journal.pone.0266523;

Hu X, Qiao D, Kim W, Moll M, Balte PP, Lange LA, Bartz TM, Kumar R, Li X, Yu B, Cade BE, Laurie CA, Sofer T, Ruczinski I, Nickerson DA, Muzny DM, Metcalf GA, Doddapaneni H, Gabriel S, Gupta N, Dugan-Perez S, Cupples LA, Loehr LR, Jain D, Rotter JI, Wilson JG, Psaty BM, Fornage M, Morrison AC, Vasan RS, Washko G, Rich SS, O'Connor GT, Bleecker E, Kaplan RC, Kalhan R, Redline S, Gharib SA, Meyers D, Ortega V, Dupuis J, London SJ, Lappalainen T, Oelsner EC, Silverman EK, Barr RG, Thornton TA, Wheeler HE, Cho MH, Im HK, Manichaikul A. Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program. Am J Hum Genet. 2022 May 05; 109(5):857-870.View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 35385699; PMCID: PMC9118106; DOI: 10.1016/j.ajhg.2022.03.007;

Lee-Sarwar K, Dedrick S, Momeni B, Kelly RS, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Laranjo N, Gold DR, Lasky-Su J, Litonjua AA, Liu YY, Weiss ST. Association of the gut microbiome and metabolome with wheeze frequency in childhood asthma. J Allergy Clin Immunol. 2022 Aug; 150(2):325-336.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 35196534; PMCID: PMC9359927; DOI: 10.1016/j.jaci.2022.02.005;

McCauley KE, Flynn K, Calatroni A, DiMassa V, LaMere B, Fadrosh DW, Lynch KV, Gill MA, Pongracic JA, Khurana Hershey GK, Kercsmar CM, Liu AH, Johnson CC, Kim H, Kattan M, O'Connor GT, Bacharier LB, Teach SJ, Gergen PJ, Wheatley LM, Togias A, LeBeau P, Presnell S, Boushey HA, Busse WW, Gern JE, Jackson DJ, Altman MC, Lynch SV. Seasonal airway microbiome and transcriptome interactions promote childhood asthma exacerbations. J Allergy Clin Immunol. 2022 Jul; 150(1):204-213. PMID: 35149044

Miller PG, Qiao D, Rojas-Quintero J, Honigberg MC, Sperling AS, Gibson CJ, Bick AG, Niroula A, McConkey ME, Sandoval B, Miller BC, Shi W, Viswanathan K, Leventhal M, Werner L, Moll M, Cade BE, Barr RG, Correa A, Cupples LA, Gharib SA, Jain D, Gogarten SM, Lange LA, London SJ, Manichaikul A, O'Connor GT, Oelsner EC, Redline S, Rich SS, Rotter JI, Ramachandran V, Yu B, Sholl L, Neuberg D, Jaiswal S, Levy BD, Owen CA, Natarajan P, Silverman EK, van Galen P, Tesfaigzi Y, Cho MH, Ebert BL. Association of clonal hematopoiesis with chronic obstructive pulmonary disease. Blood. 2022 01 20; 139(3):357-368.View Related Profiles.

O'Connor, George
Cupples, L

PMID: 34855941; PMCID: PMC8777202; DOI: 10.1182/blood.2021013531;

Bui H, Keshawarz A, Hwang SJ, Yao C, Lee GY, Recto K, O'Connor GT, Levy D. A genomic approach identifies sRAGE as a putatively causal protein for asthma. J Allergy Clin Immunol. 2022 Jun; 149(6):1992-1997.e12.View Related Profiles.

O'Connor, George
Hwang, Shih-Jen

PMID: 34974068; PMCID: PMC9177555; DOI: 10.1016/j.jaci.2021.11.027;

Clark CR, Chandler PD, Zhou G, Noel N, Achilike C, Mendez L, O'Connor GT, Smoller JW, Weiss ST, Murphy SN, Ommerborn MJ, Karnes JH, Klimentidis YC, Jordan CD, Hiatt RA, Ramirez AH, Loperena R, Mayo K, Cohn E, Ohno-Machado L, Boerwinkle E, Cicek M, Schully SD, Mockrin S, Gebo KA, Karlson EW. Geographic Variation in Obesity at the State Level in the All of Us Research Program. Prev Chronic Dis. 2021 12 23; 18:E104.View Related Profiles.

O'Connor, George
Noel, Nyia

PMID: 34941480; PMCID: PMC8718125; DOI: 10.5888/pcd18.210094;

Wan ES, Balte P, Schwartz JE, Bhatt SP, Cassano PA, Couper D, Daviglus ML, Dransfield MT, Gharib SA, Jacobs DR, Kalhan R, London SJ, Navas-Acien A, O'Connor GT, Sanders JL, Smith BM, White W, Yende S, Oelsner EC. Association Between Preserved Ratio Impaired Spirometry and Clinical Outcomes in US Adults. JAMA. 2021 12 14; 326(22):2287-2298.View Related Profiles.

Wan, Emily
O'Connor, George

PMID: 34905031; PMCID: PMC8672237; DOI: 10.1001/jama.2021.20939;

Gereige JD, Morin A, Calatroni A, Visness CM, Wood RA, Kattan M, Bacharier LB, Becker P, Altman MC, Gern JE, Ober C, O'Connor GT. 17q12-q21 variants interact with early-life exposures to modify asthma risk in Black children. Clin Exp Allergy. 2022 Apr; 52(4):565-568. PMID: 34862819

Battaglia TA, Megrath K, Spencer N, Pamphile J, Crossno C, Maschke A, Bak S, O'Connor GT, Clark CR, Sarfaty S. Communicating to Engage: An Improvisational Theater-Based Communication Training Designed to Support Community-Academic Partnership Development. Acad Med. 2021 11 01; 96(11):1564-1568.View Related Profiles.

O'Connor, George
Sarfaty, Suzanne
Battaglia, Tracy

PMID: 34406131; PMCID: PMC8551044; DOI: 10.1097/ACM.0000000000004367;

da Silva Antunes R, Sutherland A, Frazier A, Schulten V, Pomés A, Glesner J, Calatroni A, Altman MC, Wood RA, O'Connor GT, Pongracic JA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Gill M, Liu AH, Zoratti E, Kattan M, Busse PJ, Bacharier LB, Teach SJ, Wheatley LM, Togias A, Busse WW, Jackson DJ, Sette A. Heterogeneity of magnitude, allergen immunodominance, and cytokine polarization of cockroach allergen-specific T cell responses in allergic sensitized children. Clin Transl Allergy. 2021 Oct; 11(8):e12073. PMID: 34691392; PMCID: PMC8514843; DOI: 10.1002/clt2.12073;

Keshawarz A, Joehanes R, Guan W, Huan T, DeMeo DL, Grove ML, Fornage M, Levy D, O'Connor G. Longitudinal change in blood DNA epigenetic signature after smoking cessation. Epigenetics. 2022 Oct; 17(10):1098-1109. PMID: 34570667; PMCID: PMC9542417; DOI: 10.1080/15592294.2021.1985301;

Yang T, Jackson VE, Smith AV, Chen H, Bartz TM, Sitlani CM, Psaty BM, Gharib SA, O'Connor GT, Dupuis J, Xu J, Lohman K, Liu Y, Kritchevsky SB, Cassano PA, Flexeder C, Gieger C, Karrasch S, Peters A, Schulz H, Harris SE, Starr JM, Deary IJ, Manichaikul A, Oelsner EC, Barr RG, Taylor KD, Rich SS, Bonten TN, Mook-Kanamori DO, Noordam R, Li-Gao R, Jarvelin MR, Wielscher M, Terzikhan N, Lahousse L, Brusselle G, Weiss S, Ewert R, Gläser S, Homuth G, Shrine N, Hall IP, Tobin M, London SJ, Wei P, Morrison AC. Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function. Sci Rep. 2021 09 29; 11(1):19365.View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 34588469; PMCID: PMC8481467; DOI: 10.1038/s41598-021-98120-7;

Daya M, Cox C, Acevedo N, Boorgula MP, Campbell M, Chavan S, Cho MH, David GL, Kachroo P, Lasky-Su J, Li X, McHugh CP, Qiao D, Rafaels N, Beck LA, Bleecker ER, Caraballo L, Cupples AL, Figueiredo CA, Gallo RL, Hanifin J, Hansel NN, Hata TR, Hersh CP, Knight-Madden J, Leung DYM, Guttman-Yassky E, Meyers DA, O'Connor G, Ober C, Ong PY, Ortega VE, Paller AS, Putcha N, Reed RM, Schneider LC, Silverman EK, Slifka MK, Spergel JM, Vasan RS, Viaud-Martinez KA, Watson H, Weiss ST, Ruczinski I, Beaty TH, Mathias RA, Barnes KC. Multiethnic genome-wide and HLA association study of total serum IgE level. J Allergy Clin Immunol. 2021 12; 148(6):1589-1595. PMID: 34536413; PMCID: PMC8665111; DOI: 10.1016/j.jaci.2021.09.011;

Baril AA, Beiser AS, Sanchez E, Mysliwiec V, Redline S, Gottlieb DJ, O'Connor GT, Gonzales MM, Himali D, Seshadri S, Himali JJ, Pase MP. Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype. Alzheimers Dement. 2022 03; 18(3):408-421.View Related Profiles.

Beiser, Alexa
O'Connor, George
Himali, Jayandra
Seshadri, Sudha

PMID: 34310026; PMCID: PMC8802306; DOI: 10.1002/alz.12405;

Keefe J, Yao C, Hwang SJ, Courchesne P, Lee GY, Dupuis J, Mizgerd JP, O'Connor G, Washko GR, Cho MH, Silverman EK, Levy D. An Integrative Genomic Strategy Identifies sRAGE as a Causal and Protective Biomarker of Lung Function. Chest. 2022 01; 161(1):76-84.View Related Profiles.

O'Connor, George
Dupuis, Josee
Mizgerd, Joseph
Hwang, Shih-Jen

PMID: 34237330; PMCID: PMC8783029; DOI: 10.1016/j.chest.2021.06.053;

Lovinsky-Desir S, Lussier SJ, Calatroni A, Gergen PJ, Rivera-Spoljaric K, Bacharier LB, De A, O'Connor GT, Sandel MT, Wood RA, Arteaga-Solis E, Gern JE, Kattan M. Trajectories of adiposity indicators and association with asthma and lung function in urban minority children. J Allergy Clin Immunol. 2021 11; 148(5):1219-1226.e7.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 34166677; PMCID: PMC8578316; DOI: 10.1016/j.jaci.2021.06.015;

Chen YS, Mirzakhani H, Lu M, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Carey VJ, Harshfield BJ, Laranjo N, Litonjua AA, Weiss ST, Lee-Sarwar KA. The Association of Prenatal Vitamin D Sufficiency With Aeroallergen Sensitization and Allergic Rhinitis in Early Childhood. J Allergy Clin Immunol Pract. 2021 10; 9(10):3788-3796.e3.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 34166843; PMCID: PMC8511216; DOI: 10.1016/j.jaip.2021.06.009;

Altman MC, Flynn K, Rosasco MG, Dapas M, Kattan M, Lovinsky-Desir S, O'Connor GT, Gill MA, Gruchalla RS, Liu AH, Pongracic JA, Khurana Hershey GK, Zoratti EM, Teach SJ, Rastrogi D, Wood RA, Bacharier LB, LeBeau P, Gergen PJ, Togias A, Busse WW, Presnell S, Gern JE, Ober C, Jackson DJ. Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children. J Allergy Clin Immunol. 2021 12; 148(6):1505-1514. PMID: 34019912; PMCID: PMC8599524; DOI: 10.1016/j.jaci.2021.04.035;

Becker EJ, Faiz A, van den Berge M, Timens W, Hiemstra PS, Clark K, Liu G, Xiao X, Alekseyev YO, O'Connor G, Lam S, Spira A, Lenburg ME, Steiling K. Bronchial gene expression signature associated with rate of subsequent FEV1 decline in individuals with and at risk of COPD. Thorax. 2022 01; 77(1):31-39.View Related Profiles.

Spira, Avrum
Liu, Gang
O'Connor, George
Steiling, Katrina
Lenburg, Marc
Alekseyev, Yuriy

PMID: 33972452

Sanders JL, Putman RK, Dupuis J, Xu H, Murabito JM, Araki T, Nishino M, Benjamin EJ, Levy DL, Ramachandran VS, Washko GR, Curtis JL, Freeman CM, Bowler RP, Hatabu H, O'Connor GT, Hunninghake GM. The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality. Am J Respir Crit Care Med. 2021 05 01; 203(9):1149-1157.View Related Profiles.

Benjamin, Emelia
O'Connor, George
Murabito, Joanne
Dupuis, Josee
Ramachandran, Vasan

PMID: 33080140; PMCID: PMC8314902; DOI: 10.1164/rccm.202007-2993OC;

Moll M, Jackson VE, Yu B, Grove ML, London SJ, Gharib SA, Bartz TM, Sitlani CM, Dupuis J, O'Connor GT, Xu H, Cassano PA, Patchen BK, Kim WJ, Park J, Kim KH, Han B, Barr RG, Manichaikul A, Nguyen JN, Rich SS, Lahousse L, Terzikhan N, Brusselle G, Sakornsakolpat P, Liu J, Benway CJ, Hall IP, Tobin MD, Wain LV, Silverman EK, Cho MH, Hobbs BD. A systematic analysis of protein-altering exonic variants in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2021 07 01; 321(1):L130-L143.View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 33909500; PMCID: PMC8321852; DOI: 10.1152/ajplung.00009.2021;

Hallmark B, Wegienka G, Havstad S, Billheimer D, Ownby D, Mendonca EA, Gress L, Stern DA, Myers JB, Khurana Hershey GK, Hoepner L, Miller RL, Lemanske RF, Jackson DJ, Gold DR, O'Connor GT, Nicolae DL, Gern JE, Ober C, Wright AL, Martinez FD. Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood. Am J Respir Crit Care Med. 2021 04 01; 203(7):864-870. PMID: 33535024; PMCID: PMC8017591; DOI: 10.1164/rccm.202003-0820OC;

Synn AJ, Byanova KL, Li W, Gold DR, Di Q, Kloog I, Schwartz J, San José Estépar R, Washko GR, O'Connor GT, Mittleman MA, Rice MB. Ambient air pollution exposure and radiographic pulmonary vascular volumes. Environ Epidemiol. 2021 Apr; 5(2):e143. PMID: 33870015; PMCID: PMC8043731; DOI: 10.1097/EE9.0000000000000143;

Terzikhan N, Xu H, Edris A, Bracke KR, Verhamme FM, Stricker BHC, Dupuis J, Lahousse L, O'Connor GT, Brusselle GG. Epigenome-wide association study on diffusing capacity of the lung. ERJ Open Res. 2021 Jan; 7(1).View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 33748261; PMCID: PMC7957297; DOI: 10.1183/23120541.00567-2020;

Ramratnam SK, Lockhart A, Visness CM, Calatroni A, Jackson DJ, Gergen PJ, Bacharier LB, O'Connor GT, Sandel MT, Kattan M, Wood RA, Gern JE. Maternal stress and depression are associated with respiratory phenotypes in urban children. J Allergy Clin Immunol. 2021 07; 148(1):120-127.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 33713764; PMCID: PMC8273133; DOI: 10.1016/j.jaci.2021.03.005;

Altman MC, Calatroni A, Ramratnam S, Jackson DJ, Presnell S, Rosasco MG, Gergen PJ, Bacharier LB, O'Connor GT, Sandel MT, Kattan M, Wood RA, Visness CM, Gern JE. Endotype of allergic asthma with airway obstruction in urban children. J Allergy Clin Immunol. 2021 11; 148(5):1198-1209.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 33713771; PMCID: PMC8429519; DOI: 10.1016/j.jaci.2021.02.040;

Yola IM, Oh A, Mitchell GF, O'Connor G, Cheng S, Vasan RS, Xanthakis V. Association of lung diffusion capacity with cardiac remodeling and risk of heart failure: The Framingham heart study. PLoS One. 2021; 16(2):e0246355.View Related Profiles.

Oh, Albin
O'Connor, George
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PMID: 33592021; PMCID: PMC7886141; DOI: 10.1371/journal.pone.0246355;

Knihtilä HM, Stubbs BJ, Carey VJ, Laranjo N, Chu SH, Kelly RS, Zeiger RS, Bacharier LB, O'Connor GT, Lasky-Su J, Weiss ST, Litonjua AA. Low gestational vitamin D level and childhood asthma are related to impaired lung function in high-risk children. J Allergy Clin Immunol. 2021 07; 148(1):110-119.e9. PMID: 33485958; PMCID: PMC8315297; DOI: 10.1016/j.jaci.2020.12.647;

Synn AJ, Li W, San José Estépar R, Washko GR, O'Connor GT, Tsao CW, Mittleman MA, Rice MB. Pulmonary Vascular Pruning on Computed Tomography and Risk of Death in the Framingham Heart Study. Am J Respir Crit Care Med. 2021 01 15; 203(2):251-254. PMID: 32926788; PMCID: PMC7874407; DOI: 10.1164/rccm.202005-1671LE;

Kim JS, Steffen BT, Podolanczuk AJ, Kawut SM, Noth I, Raghu G, Michos ED, Hoffman EA, Axelsson GT, Gudmundsson G, Gudnason V, Gudmundsson EF, Murphy RA, Dupuis J, Xu H, Vasan RS, O'Connor GT, Harris WS, Hunninghake GM, Barr RG, Tsai MY, Lederer DJ. Associations of ?-3 Fatty Acids With Interstitial Lung Disease and Lung Imaging Abnormalities Among Adults. Am J Epidemiol. 2021 01 04; 190(1):95-108.View Related Profiles.

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Dupuis, Josee

PMID: 32803215; PMCID: PMC7784523; DOI: 10.1093/aje/kwaa168;

Parikh R, Rao SR, Kukde R, O'Connor GT, Patel A, Hibberd PL. Assessing the Respiratory Effects of Air Pollution from Biomass Cookstoves on Pregnant Women in Rural India. Int J Environ Res Public Health. 2020 12 29; 18(1).View Related Profiles.

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PMID: 33383756; PMCID: PMC7795669; DOI: 10.3390/ijerph18010183;

Lovinsky-Desir S, O'Connor GT. Evolving Strategies for Long-term Asthma Management. JAMA. 2020 12 08; 324(22):2265-2267. PMID: 33270088

Zhao X, Qiao D, Yang C, Kasela S, Kim W, Ma Y, Shrine N, Batini C, Sofer T, Taliun SAG, Sakornsakolpat P, Balte PP, Prokopenko D, Yu B, Lange LA, Dupuis J, Cade BE, Lee J, Gharib SA, Daya M, Laurie CA, Ruczinski I, Cupples LA, Loehr LR, Bartz TM, Morrison AC, Psaty BM, Vasan RS, Wilson JG, Taylor KD, Durda P, Johnson WC, Cornell E, Guo X, Liu Y, Tracy RP, Ardlie KG, Aguet F, VanDenBerg DJ, Papanicolaou GJ, Rotter JI, Barnes KC, Jain D, Nickerson DA, Muzny DM, Metcalf GA, Doddapaneni H, Dugan-Perez S, Gupta N, Gabriel S, Rich SS, O'Connor GT, Redline S, Reed RM, Laurie CC, Daviglus ML, Preudhomme LK, Burkart KM, Kaplan RC, Wain LV, Tobin MD, London SJ, Lappalainen T, Oelsner EC, Abecasis GR, Silverman EK, Barr RG, Cho MH, Manichaikul A. Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants. Nat Commun. 2020 10 14; 11(1):5182.View Related Profiles.

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Dupuis, Josee
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PMID: 33057025; PMCID: PMC7598941; DOI: 10.1038/s41467-020-18334-7;

Cornelius T, Schwartz JE, Balte P, Bhatt SP, Cassano PA, Currow D, Jacobs DR, Johnson M, Kalhan R, Kronmal R, Loehr L, O'Connor GT, Smith B, White WB, Yende S, Oelsner EC. A Dyadic Growth Modeling Approach for Examining Associations Between Weight Gain and Lung Function Decline. Am J Epidemiol. 2020 10 01; 189(10):1173-1184. PMID: 32286615; PMCID: PMC7670871; DOI: 10.1093/aje/kwaa059;

McKennan C, Naughton K, Stanhope C, Kattan M, O'Connor GT, Sandel MT, Visness CM, Wood RA, Bacharier LB, Beigelman A, Lovinsky-Desir S, Togias A, Gern JE, Nicolae D, Ober C. Longitudinal data reveal strong genetic and weak non-genetic components of ethnicity-dependent blood DNA methylation levels. Epigenetics. 2021 06; 16(6):662-676.View Related Profiles.

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Sandel, Megan

PMID: 32997571; PMCID: PMC8143220; DOI: 10.1080/15592294.2020.1817290;

Araki T, Washko GR, Schiebler ML, O'Connor GT, Hatabu H. The Framingham Heart Study: Populational CT-based phenotyping in the lungs and mediastinum. Eur J Radiol Open. 2020; 7:100260. PMID: 32984450; PMCID: PMC7495061; DOI: 10.1016/j.ejro.2020.100260;

Lu M, Litonjua AA, O'Connor GT, Zeiger RS, Bacharier L, Schatz M, Carey VJ, Weiss ST, Mirzakhani H. Effect of early and late prenatal vitamin D and maternal asthma status on offspring asthma or recurrent wheeze. J Allergy Clin Immunol. 2021 04; 147(4):1234-1241.e3. PMID: 32822692; PMCID: PMC7892633; DOI: 10.1016/j.jaci.2020.06.041;

Synn AJ, Li W, Hunninghake GM, Washko GR, San José Estépar R, O'Connor GT, Kholdani CA, Hallowell RW, Bankier AA, Mittleman MA, Rice MB. Vascular Pruning on CT and Interstitial Lung Abnormalities in the Framingham Heart Study. Chest. 2021 02; 159(2):663-672. PMID: 32798523; PMCID: PMC7856535; DOI: 10.1016/j.chest.2020.07.082;

Nayor M, Xanthakis V, Tanguay M, Blodgett JB, Shah RV, Schoenike M, Sbarbaro J, Farrell R, Malhotra R, Houstis NE, Velagaleti RS, Moore SA, Baggish AL, O'Connor GT, Ho JE, Larson MG, Vasan RS, Lewis GD. Clinical and Hemodynamic Associations and Prognostic Implications of Ventilatory Efficiency in Patients With Preserved Left Ventricular Systolic Function. Circ Heart Fail. 2020 05; 13(5):e006729.View Related Profiles.

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Larson, Martin
Nayor, Matthew
Velagaleti, Raghava
Xanthakis, Vanessa

PMID: 32362167; PMCID: PMC7224335; DOI: 10.1161/CIRCHEARTFAILURE.119.006729;

Ober C, McKennan CG, Magnaye KM, Altman MC, Washington C, Stanhope C, Naughton KA, Rosasco MG, Bacharier LB, Billheimer D, Gold DR, Gress L, Hartert T, Havstad S, Khurana Hershey GK, Hallmark B, Hogarth DK, Jackson DJ, Johnson CC, Kattan M, Lemanske RF, Lynch SV, Mendonca EA, Miller RL, Naureckas ET, O'Connor GT, Seroogy CM, Wegienka G, White SR, Wood RA, Wright AL, Zoratti EM, Martinez FD, Ownby D, Nicolae DL, Levin AM, Gern JE. Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study. Lancet Respir Med. 2020 05; 8(5):482-492. PMID: 32380068; PMCID: PMC7335429; DOI: 10.1016/S2213-2600(20)30011-4;

Balte PP, Chaves PHM, Couper DJ, Enright P, Jacobs DR, Kalhan R, Kronmal RA, Loehr LR, London SJ, Newman AB, O'Connor GT, Schwartz JE, Smith BM, Smith LJ, White WB, Yende S, Oelsner EC. Association of Nonobstructive Chronic Bronchitis With Respiratory Health Outcomes in Adults. JAMA Intern Med. 2020 05 01; 180(5):676-686. PMID: 32119036; PMCID: PMC7052787; DOI: 10.1001/jamainternmed.2020.0104;

Jackson DJ, Busse WW, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Visness CM, Durham SR, Larson D, Esnault S, Ober C, Gergen PJ, Becker P, Togias A, Gern JE, Altman MC. Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2. J Allergy Clin Immunol. 2020 Jul; 146(1):203-206.e3. PMID: 32333915; PMCID: PMC7175851; DOI: 10.1016/j.jaci.2020.04.009;

Bou Jawde S, Walkey AJ, Majumdar A, O'Connor GT, Smith BJ, Bates JHT, Lutchen KR, Suki B. Tracking respiratory mechanics around natural breathing rates via variable ventilation. Sci Rep. 2020 04 21; 10(1):6722.View Related Profiles.

Walkey, Allan
Suki, Bela
O'Connor, George
Lutchen, Kenneth

PMID: 32317734; PMCID: PMC7174375; DOI: 10.1038/s41598-020-63663-8;

Allen RJ, Guillen-Guio B, Oldham JM, Ma SF, Dressen A, Paynton ML, Kraven LM, Obeidat M, Li X, Ng M, Braybrooke R, Molina-Molina M, Hobbs BD, Putman RK, Sakornsakolpat P, Booth HL, Fahy WA, Hart SP, Hill MR, Hirani N, Hubbard RB, McAnulty RJ, Millar AB, Navaratnam V, Oballa E, Parfrey H, Saini G, Whyte MKB, Zhang Y, Kaminski N, Adegunsoye A, Strek ME, Neighbors M, Sheng XR, Gudmundsson G, Gudnason V, Hatabu H, Lederer DJ, Manichaikul A, Newell JD, O'Connor GT, Ortega VE, Xu H, Fingerlin TE, Bossé Y, Hao K, Joubert P, Nickle DC, Sin DD, Timens W, Furniss D, Morris AP, Zondervan KT, Hall IP, Sayers I, Tobin MD, Maher TM, Cho MH, Hunninghake GM, Schwartz DA, Yaspan BL, Molyneaux PL, Flores C, Noth I, Jenkins RG, Wain LV. Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2020 03 01; 201(5):564-574. PMID: 31710517; PMCID: PMC7047454; DOI: 10.1164/rccm.201905-1017OC;

Zoratti EM, O'Connor GT. New Therapeutic Strategies for Asthma. JAMA. 2020 02 11; 323(6):517-518. PMID: 32044924

Litonjua AA, Carey VJ, Laranjo N, Stubbs BJ, Mirzakhani H, O'Connor GT, Sandel M, Beigelman A, Bacharier LB, Zeiger RS, Schatz M, Hollis BW, Weiss ST. Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction. N Engl J Med. 2020 02 06; 382(6):525-533.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 32023372; PMCID: PMC7444088; DOI: 10.1056/NEJMoa1906137;

Jackson DJ, Bacharier LB, Calatroni A, Gill MA, Hu J, Liu AH, Wheatley LM, Gern JE, Gruchalla RS, Khurana Hershey GK, Kattan M, Kercsmar CM, Kim H, O'Connor GT, Patel S, Pongracic JA, Wood RA, Busse WW. Serum IL-6: A biomarker in childhood asthma? J Allergy Clin Immunol. 2020 06; 145(6):1701-1704.e3. PMID: 32004524; PMCID: PMC7282967; DOI: 10.1016/j.jaci.2020.01.021;

Hobbs BD, Putman RK, Araki T, Nishino M, Gudmundsson G, Gudnason V, Eiriksdottir G, Zilhao Nogueira NR, Dupuis J, Xu H, O'Connor GT, Manichaikul A, Nguyen J, Podolanczuk AJ, Madahar P, Rotter JI, Lederer DJ, Barr RG, Rich SS, Ampleford EJ, Ortega VE, Peters SP, O'Neal WK, Newell JD, Bleecker ER, Meyers DA, Allen RJ, Oldham JM, Ma SF, Noth I, Jenkins RG, Maher TM, Hubbard RB, Wain LV, Fingerlin TE, Schwartz DA, Washko GR, Rosas IO, Silverman EK, Hatabu H, Cho MH, Hunninghake GM. Overlap of Genetic Risk between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 12 01; 200(11):1402-1413.View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 31339356; PMCID: PMC6884045; DOI: 10.1164/rccm.201903-0511OC;

Oelsner EC, Balte PP, Bhatt SP, Cassano PA, Couper D, Folsom AR, Freedman ND, Jacobs DR, Kalhan R, Mathew AR, Kronmal RA, Loehr LR, London SJ, Newman AB, O'Connor GT, Schwartz JE, Smith LJ, White WB, Yende S. Lung function decline in former smokers and low-intensity current smokers: a secondary data analysis of the NHLBI Pooled Cohorts Study. Lancet Respir Med. 2020 01; 8(1):34-44. PMID: 31606435; PMCID: PMC7261004; DOI: 10.1016/S2213-2600(19)30276-0;

Synn AJ, Li W, San José Estépar R, Zhang C, Washko GR, O'Connor GT, Araki T, Hatabu H, Bankier AA, Mittleman MA, Rice MB. Radiographic pulmonary vessel volume, lung function and airways disease in the Framingham Heart Study. Eur Respir J. 2019 09; 54(3). PMID: 31248956; PMCID: PMC7173739; DOI: 10.1183/13993003.00408-2019;

Lee-Sarwar KA, Kelly RS, Lasky-Su J, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Rifas-Shiman SL, Carey VJ, Harshfield BJ, Laranjo N, Gold DR, Weiss ST, Litonjua AA. Fecal short-chain fatty acids in pregnancy and offspring asthma and allergic outcomes. J Allergy Clin Immunol Pract. 2020 03; 8(3):1100-1102.e13.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 31494295; PMCID: PMC7056490; DOI: 10.1016/j.jaip.2019.08.036;

Mirzakhani H, Carey VJ, McElrath TF, Hollis BW, O'Connor GT, Zeiger RS, Bacharier L, Litonjua AA, Weiss ST. Maternal Asthma, Preeclampsia, and Risk for Childhood Asthma at Age Six. Am J Respir Crit Care Med. 2019 09 01; 200(5):638-642. PMID: 31059286; PMCID: PMC6727151; DOI: 10.1164/rccm.201901-0081LE;

Rice MB, Li W, Schwartz J, Di Q, Kloog I, Koutrakis P, Gold DR, Hallowell RW, Zhang C, O'Connor G, Washko GR, Hunninghake GM, Mittleman MA. Ambient air pollution exposure and risk and progression of interstitial lung abnormalities: the Framingham Heart Study. Thorax. 2019 11; 74(11):1063-1069. PMID: 31391318; PMCID: PMC7136036; DOI: 10.1136/thoraxjnl-2018-212877;

Bhatt SP, Balte PP, Schwartz JE, Cassano PA, Couper D, Jacobs DR, Kalhan R, O'Connor GT, Yende S, Sanders JL, Umans JG, Dransfield MT, Chaves PH, White WB, Oelsner EC. Discriminative Accuracy of FEV1:FVC Thresholds for COPD-Related Hospitalization and Mortality. JAMA. 2019 06 25; 321(24):2438-2447. PMID: 31237643; PMCID: PMC6593636; DOI: 10.1001/jama.2019.7233;

Corbett SE, Nitzberg M, Moses E, Kleerup E, Wang T, Perdomo C, Perdomo C, Liu G, Xiao X, Liu H, Elashoff DA, Brooks DR, O'Connor GT, Dubinett SM, Spira A, Lenburg ME. Gene Expression Alterations in the Bronchial Epithelium of e-Cigarette Users. Chest. 2019 10; 156(4):764-773.View Related Profiles.

Spira, Avrum
Brooks, Daniel
Moses, Elizabeth
Liu, Gang
O'Connor, George
Liu, Hanqiao
Lenburg, Marc

PMID: 31233743; PMCID: PMC6859252; DOI: 10.1016/j.chest.2019.05.022;

Pomés A, Glesner J, Calatroni A, Visness CM, Wood RA, O'Connor GT, Kattan M, Bacharier LB, Wheatley LM, Gern JE, Busse WW. Cockroach allergen component analysis of children with or without asthma and rhinitis in an inner-city birth cohort. J Allergy Clin Immunol. 2019 10; 144(4):935-944. PMID: 31201891; PMCID: PMC7307589; DOI: 10.1016/j.jaci.2019.05.036;

Gern JE, Jackson DJ, Lemanske RF, Seroogy CM, Tachinardi U, Craven M, Hwang SY, Hamilton CM, Huggins W, O'Connor GT, Gold DR, Miller R, Kattan M, Johnson CC, Ownby D, Zoratti EM, Wood RA, Visness CM, Martinez F, Wright A, Lynch S, Ober C, Khurana Hershey GK, Ryan P, Hartert T, Bacharier LB. The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population. Respir Res. 2019 Jun 10; 20(1):115. PMID: 31182091; PMCID: PMC6558735; DOI: 10.1186/s12931-019-1088-9;

Synn AJ, Zhang C, Washko GR, Estépar RSJ, O'Connor GT, Li W, Mittleman MA, Rice MB. Cigarette Smoke Exposure and Radiographic Pulmonary Vascular Morphology in the Framingham Heart Study. Ann Am Thorac Soc. 2019 06; 16(6):698-706. PMID: 30714821; PMCID: PMC6543477; DOI: 10.1513/AnnalsATS.201811-795OC;

Schulten V, Frazier A, Calatroni A, Kattan M, Bacharier LB, O'Connor GT, Sandel MT, Wood RA, Wheatley LM, Togias A, Visness CM, Dresen A, Gern JE, Sette A. The association of allergic sensitization patterns in early childhood with disease manifestations and immunological reactivity at 10 years of age. Clin Exp Allergy. 2019 08; 49(8):1087-1094.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 31046157; PMCID: PMC6896992; DOI: 10.1111/cea.13406;

Hijazi K, Malyszko B, Steiling K, Xiao X, Liu G, Alekseyev YO, Dumas YM, Hertsgaard L, Jensen J, Hatsukami D, Brooks DR, O'Connor G, Beane J, Lenburg ME, Spira A. Tobacco-Related Alterations in Airway Gene Expression are Rapidly Reversed Within Weeks Following Smoking-Cessation. Sci Rep. 2019 05 06; 9(1):6978.View Related Profiles.

Spira, Avrum
Brooks, Daniel
Liu, Gang
O'Connor, George
Beane-Ebel, Jennifer
Steiling, Katrina
Lenburg, Marc
Alekseyev, Yuriy
Dumas, Yves-Martine

PMID: 31061400; PMCID: PMC6502805; DOI: 10.1038/s41598-019-43295-3;

Altman MC, Gill MA, Whalen E, Babineau DC, Shao B, Liu AH, Jepson B, Gruchalla RS, O'Connor GT, Pongracic JA, Kercsmar CM, Khurana Hershey GK, Zoratti EM, Johnson CC, Teach SJ, Kattan M, Bacharier LB, Beigelman A, Sigelman SM, Presnell S, Gern JE, Gergen PJ, Wheatley LM, Togias A, Busse WW, Jackson DJ. Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children. Nat Immunol. 2019 05; 20(5):637-651. PMID: 30962590; PMCID: PMC6472965; DOI: 10.1038/s41590-019-0347-8;

Miller ER, Putman RK, Diaz AA, Xu H, San José Estépar R, Araki T, Nishino M, Poli de Frías S, Hida T, Ross J, Coxson H, Dupuis J, O'Connor GT, Silverman EK, Rosas IO, Hatabu H, Washko G, Hunninghake GM. Increased Airway Wall Thickness in Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2019 04; 16(4):447-454.View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 30543456; PMCID: PMC6441702; DOI: 10.1513/AnnalsATS.201806-424OC;

Lee-Sarwar KA, Kelly RS, Lasky-Su J, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Laranjo N, Gold DR, Weiss ST, Litonjua AA. Integrative analysis of the intestinal metabolome of childhood asthma. J Allergy Clin Immunol. 2019 08; 144(2):442-454.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 30914378; PMCID: PMC6688902; DOI: 10.1016/j.jaci.2019.02.032;

Sordillo JE, Korrick S, Laranjo N, Carey V, Weinstock GM, Gold DR, O'Connor G, Sandel M, Bacharier LB, Beigelman A, Zeiger R, Litonjua AA, Weiss ST. Association of the Infant Gut Microbiome With Early Childhood Neurodevelopmental Outcomes: An Ancillary Study to the VDAART Randomized Clinical Trial. JAMA Netw Open. 2019 03 01; 2(3):e190905.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 30901046; PMCID: PMC6583279; DOI: 10.1001/jamanetworkopen.2019.0905;

Xu J, Gaddis NC, Bartz TM, Hou R, Manichaikul AW, Pankratz N, Smith AV, Sun F, Terzikhan N, Markunas CA, Patchen BK, Schu M, Beydoun MA, Brusselle GG, Eiriksdottir G, Zhou X, Wood AC, Graff M, Harris TB, Ikram MA, Jacobs DR, Launer LJ, Lemaitre RN, O'Connor GT, Oelsner EC, Psaty BM, Vasan RS, Rohde RR, Rich SS, Rotter JI, Seshadri S, Smith LJ, Tiemeier H, Tsai MY, Uitterlinden AG, Voruganti VS, Xu H, Zilhão NR, Fornage M, Zillikens MC, London SJ, Barr RG, Dupuis J, Gharib SA, Gudnason V, Lahousse L, North KE, Steffen LM, Cassano PA, Hancock DB. Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association. Am J Respir Crit Care Med. 2019 03 01; 199(5):631-642.View Related Profiles.

O'Connor, George
Dupuis, Josee
Seshadri, Sudha
Ramachandran, Vasan

PMID: 30199657; PMCID: PMC6396866; DOI: 10.1164/rccm.201802-0304OC;

Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N, Qiao D, Bartz TM, Kim DK, Lee MK, Latourelle JC, Li X, Morrow JD, Obeidat M, Wyss AB, Bakke P, Barr RG, Beaty TH, Belinsky SA, Brusselle GG, Crapo JD, de Jong K, DeMeo DL, Fingerlin TE, Gharib SA, Gulsvik A, Hall IP, Hokanson JE, Kim WJ, Lomas DA, London SJ, Meyers DA, O'Connor GT, Rennard SI, Schwartz DA, Sliwinski P, Sparrow D, Strachan DP, Tal-Singer R, Tesfaigzi Y, Vestbo J, Vonk JM, Yim JJ, Zhou X, Bossé Y, Manichaikul A, Lahousse L, Silverman EK, Boezen HM, Wain LV, Tobin MD, Hobbs BD, Cho MH. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. Nat Genet. 2019 03; 51(3):494-505.View Related Profiles.

Sparrow, David
O'Connor, George
Latourelle, Jeanne

PMID: 30804561; PMCID: PMC6546635; DOI: 10.1038/s41588-018-0342-2;

Oelsner EC, Balte PP, Grams ME, Cassano PA, Jacobs DR, Barr RG, Burkart KM, Kalhan R, Kronmal R, Loehr LR, O'Connor GT, Schwartz JE, Shlipak M, Tracy RP, Tsai MY, White W, Yende S. Albuminuria, Lung Function Decline, and Risk of Incident Chronic Obstructive Pulmonary Disease. The NHLBI Pooled Cohorts Study. Am J Respir Crit Care Med. 2019 02 01; 199(3):321-332. PMID: 30261735; PMCID: PMC6363973; DOI: 10.1164/rccm.201803-0402OC;

Borrelli B, O'Connor GT. E-Cigarettes to Assist with Smoking Cessation. N Engl J Med. 2019 02 14; 380(7):678-679.View Related Profiles.

Borrelli, Belinda
O'Connor, George

PMID: 30699299

Mirzakhani H, Carey VJ, Zeiger R, Bacharier LB, O'Connor GT, Schatz MX, Laranjo N, Weiss ST, Litonjua AA. Impact of parental asthma, prenatal maternal asthma control, and vitamin D status on risk of asthma and recurrent wheeze in 3-year-old children. Clin Exp Allergy. 2019 04; 49(4):419-429. PMID: 30461089; PMCID: PMC6438751; DOI: 10.1111/cea.13320;

Rice MB, Li W, Wilker EH, Gold DR, Schwartz J, Zanobetti A, Koutrakis P, Kloog I, Washko GR, O'Connor GT, Mittleman MA. Association of outdoor temperature with lung function in a temperate climate. Eur Respir J. 2019 01; 53(1). PMID: 30578386; PMCID: PMC6903481; DOI: 10.1183/13993003.00612-2018;

Mirzakhani H, Carey VJ, McElrath TF, Qiu W, Hollis BW, O'Connor GT, Zeiger RS, Bacharier L, Litonjua AA, Weiss ST. Impact of Preeclampsia on the Relationship between Maternal Asthma and Offspring Asthma. An Observation from the VDAART Clinical Trial. Am J Respir Crit Care Med. 2019 01 01; 199(1):32-42. PMID: 30153046; PMCID: PMC6353019; DOI: 10.1164/rccm.201804-0770OC;

Bacharier LB, Beigelman A, Calatroni A, Jackson DJ, Gergen PJ, O'Connor GT, Kattan M, Wood RA, Sandel MT, Lynch SV, Fujimura KE, Fadrosh DW, Santee CA, Boushey H, Visness CM, Gern JE. Longitudinal Phenotypes of Respiratory Health in a High-Risk Urban Birth Cohort. Am J Respir Crit Care Med. 2019 01 01; 199(1):71-82.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 30079758; PMCID: PMC6353010; DOI: 10.1164/rccm.201801-0190OC;

Karvonen AM, Sordillo JE, Gold DR, Bacharier LB, O'Connor GT, Zeiger RS, Beigelman A, Weiss ST, Litonjua AA. Gut microbiota and overweight in 3-year old children. Int J Obes (Lond). 2019 04; 43(4):713-723. PMID: 30568265; PMCID: PMC6457121; DOI: 10.1038/s41366-018-0290-z;

Kercsmar CM, Sorkness CA, Calatroni A, Gergen PJ, Bloomberg GR, Gruchalla RS, Kattan M, Liu AH, O'Connor GT, Pongracic JA, Szefler SJ, Teach SJ, Wildfire JJ, Wood RA, Zoratti EM, Busse WW. A computerized decision support tool to implement asthma guidelines for children and adolescents. J Allergy Clin Immunol. 2019 05; 143(5):1760-1768. PMID: 30529451; PMCID: PMC6504600; DOI: 10.1016/j.jaci.2018.10.060;

Oelsner EC, Balte PP, Cassano PA, Couper D, Enright PL, Folsom AR, Hankinson J, Jacobs DR, Kalhan R, Kaplan R, Kronmal R, Lange L, Loehr LR, London SJ, Navas Acien A, Newman AB, O'Connor GT, Schwartz JE, Smith LJ, Yeh F, Zhang Y, Moran AE, Mwasongwe S, White WB, Yende S, Barr RG. Harmonization of Respiratory Data From 9 US Population-Based Cohorts: The NHLBI Pooled Cohorts Study. Am J Epidemiol. 2018 11 01; 187(11):2265-2278. PMID: 29982273; PMCID: PMC6211239; DOI: 10.1093/aje/kwy139;

Terzikhan N, Sun F, Verhamme FM, Adams HHH, Loth D, Bracke KR, Stricker BHC, Lahousse L, Dupuis J, Brusselle GG, O'Connor GT. Heritability and genome-wide association study of diffusing capacity of the lung. Eur Respir J. 2018 09; 52(3).View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 30049742

Xu J, Bartz TM, Chittoor G, Eiriksdottir G, Manichaikul AW, Sun F, Terzikhan N, Zhou X, Booth SL, Brusselle GG, de Boer IH, Fornage M, Frazier-Wood AC, Graff M, Gudnason V, Harris TB, Hofman A, Hou R, Houston DK, Jacobs DR, Kritchevsky SB, Latourelle J, Lemaitre RN, Lutsey PL, O'Connor G, Oelsner EC, Pankow JS, Psaty BM, Rohde RR, Rich SS, Rotter JI, Smith LJ, Stricker BH, Voruganti VS, Wang TJ, Zillikens MC, Barr RG, Dupuis J, Gharib SA, Lahousse L, London SJ, North KE, Smith AV, Steffen LM, Hancock DB, Cassano PA. Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function. Br J Nutr. 2018 11; 120(10):1159-1170.View Related Profiles.

O'Connor, George
Latourelle, Jeanne
Dupuis, Josee

PMID: 30205856; PMCID: PMC6263170; DOI: 10.1017/S0007114518002180;

Savage JH, Lee-Sarwar KA, Sordillo JE, Lange NE, Zhou Y, O'Connor GT, Sandel M, Bacharier LB, Zeiger R, Sodergren E, Weinstock GM, Gold DR, Weiss ST, Litonjua AA. Diet during Pregnancy and Infancy and the Infant Intestinal Microbiome. J Pediatr. 2018 12; 203:47-54.e4.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 30173873; PMCID: PMC6371799; DOI: 10.1016/j.jpeds.2018.07.066;

Lee-Sarwar K, Kelly RS, Lasky-Su J, Kachroo P, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Laranjo N, Gold DR, Weiss ST, Litonjua AA. Dietary and Plasma Polyunsaturated Fatty Acids Are Inversely Associated with Asthma and Atopy in Early Childhood. J Allergy Clin Immunol Pract. 2019 02; 7(2):529-538.e8.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 30145365; PMCID: PMC6400588; DOI: 10.1016/j.jaip.2018.07.039;

Wyss AB, Sofer T, Lee MK, Terzikhan N, Nguyen JN, Lahousse L, Latourelle JC, Smith AV, Bartz TM, Feitosa MF, Gao W, Ahluwalia TS, Tang W, Oldmeadow C, Duan Q, de Jong K, Wojczynski MK, Wang XQ, Noordam R, Hartwig FP, Jackson VE, Wang T, Obeidat M, Hobbs BD, Huan T, Gui H, Parker MM, Hu D, Mogil LS, Kichaev G, Jin J, Graff M, Harris TB, Kalhan R, Heckbert SR, Paternoster L, Burkart KM, Liu Y, Holliday EG, Wilson JG, Vonk JM, Sanders JL, Barr RG, de Mutsert R, Menezes AMB, Adams HHH, van den Berge M, Joehanes R, Levin AM, Liberto J, Launer LJ, Morrison AC, Sitlani CM, Celedón JC, Kritchevsky SB, Scott RJ, Christensen K, Rotter JI, Bonten TN, Wehrmeister FC, Bossé Y, Xiao S, Oh S, Franceschini N, Brody JA, Kaplan RC, Lohman K, McEvoy M, Province MA, Rosendaal FR, Taylor KD, Nickle DC, Williams LK, Burchard EG, Wheeler HE, Sin DD, Gudnason V, North KE, Fornage M, Psaty BM, Myers RH, O'Connor G, Hansen T, Laurie CC, Cassano PA, Sung J, Kim WJ, Attia JR, Lange L, Boezen HM, Thyagarajan B, Rich SS, Mook-Kanamori DO, Horta BL, Uitterlinden AG, Im HK, Cho MH, Brusselle GG, Gharib SA, Dupuis J, Manichaikul A, London SJ. Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function. Nat Commun. 2018 07 30; 9(1):2976.View Related Profiles.

O'Connor, George
Latourelle, Jeanne
Dupuis, Josee
Myers, Richard

PMID: 30061609; PMCID: PMC6065313; DOI: 10.1038/s41467-018-05369-0;

Hurley K, O'Connor GT. Serum a1-Antitrypsin Concentration in the Diagnosis of a1-Antitrypsin Deficiency. JAMA. 2018 May 15; 319(19):2034-2035. PMID: 29800192

Lee-Sarwar K, Kelly RS, Lasky-Su J, Moody DB, Mola AR, Cheng TY, Comstock LE, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Laranjo N, Gold DR, Bunyavanich S, Savage JH, Weiss ST, Brennan PJ, Litonjua AA. Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy. J Allergy Clin Immunol. 2018 07; 142(1):335-338.e9.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 29729303; PMCID: PMC6433125; DOI: 10.1016/j.jaci.2018.04.016;

Rice MB, Li W, Dorans KS, Wilker EH, Ljungman P, Gold DR, Schwartz J, Koutrakis P, Kloog I, Araki T, Hatabu H, San Jose Estepar R, O'Connor GT, Mittleman MA, Washko GR. Exposure to Traffic Emissions and Fine Particulate Matter and Computed Tomography Measures of the Lung and Airways. Epidemiology. 2018 05; 29(3):333-341. PMID: 29384790; PMCID: PMC6095201; DOI: 10.1097/EDE.0000000000000809;

Altman MC, Whalen E, Togias A, O'Connor GT, Bacharier LB, Bloomberg GR, Kattan M, Wood RA, Presnell S, LeBeau P, Jaffee K, Visness CM, Busse WW, Gern JE. Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma. J Allergy Clin Immunol. 2018 12; 142(6):1856-1866. PMID: 29518416; PMCID: PMC6123299; DOI: 10.1016/j.jaci.2018.02.019;

Kattan M, Bacharier LB, O'Connor GT, Cohen R, Sorkness RL, Morgan W, Gergen PJ, Jaffee KF, Visness CM, Wood RA, Bloomberg GR, Doyle S, Burton R, Gern JE. Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy. J Allergy Clin Immunol Pract. 2018 Sep - Oct; 6(5):1596-1603.e6. PMID: 29449165; PMCID: PMC6089669; DOI: 10.1016/j.jaip.2017.12.028;

Chandra S, Wingender G, Greenbaum JA, Khurana A, Gholami AM, Ganesan AP, Rosenbach M, Jaffee K, Gern JE, Wood R, O'Connor G, Sandel M, Kattan M, Bacharier L, Togias A, Horner AA, Kronenberg M. Development of Asthma in Inner-City Children: Possible Roles of MAIT Cells and Variation in the Home Environment. J Immunol. 2018 03 15; 200(6):1995-2003.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 29431692; PMCID: PMC5840005; DOI: 10.4049/jimmunol.1701525;

Jackson VE, Latourelle JC, Wain LV, Smith AV, Grove ML, Bartz TM, Obeidat M, Province MA, Gao W, Qaiser B, Porteous DJ, Cassano PA, Ahluwalia TS, Grarup N, Li J, Altmaier E, Marten J, Harris SE, Manichaikul A, Pottinger TD, Li-Gao R, Lind-Thomsen A, Mahajan A, Lahousse L, Imboden M, Teumer A, Prins B, Lyytikäinen LP, Eiriksdottir G, Franceschini N, Sitlani CM, Brody JA, Bossé Y, Timens W, Kraja A, Loukola A, Tang W, Liu Y, Bork-Jensen J, Justesen JM, Linneberg A, Lange LA, Rawal R, Karrasch S, Huffman JE, Smith BH, Davies G, Burkart KM, Mychaleckyj JC, Bonten TN, Enroth S, Lind L, Brusselle GG, Kumar A, Stubbe B, Kähönen M, Wyss AB, Psaty BM, Heckbert SR, Hao K, Rantanen T, Kritchevsky SB, Lohman K, Skaaby T, Pisinger C, Hansen T, Schulz H, Polasek O, Campbell A, Starr JM, Rich SS, Mook-Kanamori DO, Johansson Å, Ingelsson E, Uitterlinden AG, Weiss S, Raitakari OT, Gudnason V, North KE, Gharib SA, Sin DD, Taylor KD, O'Connor GT, Kaprio J, Harris TB, Pederson O, Vestergaard H, Wilson JG, Strauch K, Hayward C, Kerr S, Deary IJ, Barr RG, de Mutsert R, Gyllensten U, Morris AP, Ikram MA, Probst-Hensch N, Gläser S, Zeggini E, Lehtimäki T, Strachan DP, Dupuis J, Morrison AC, Hall IP, Tobin MD, London SJ. Meta-analysis of exome array data identifies six novel genetic loci for lung function. Wellcome Open Res. 2018; 3:4.View Related Profiles.

O'Connor, George
Latourelle, Jeanne
Dupuis, Josee

PMID: 30175238; PMCID: PMC6081985; DOI: 10.12688/wellcomeopenres.12583.3;

Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmüller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bønnelykke K, Boomsma DI, Bouzigon E, Brightling CE, Brossard M, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Couto Alves A, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA, Freidin MB, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib SA, Gilliland F, Granell R, Graves PE, Gudbjartsson DF, Haahtela T, Heckbert SR, Heederik D, Heinrich J, Heliövaara M, Henderson J, Himes BE, Hirose H, Hirschhorn JN, Hofman A, Holt P, Hottenga J, Hudson TJ, Hui J, Imboden M, Ivanov V, Jaddoe VWV, James A, Janson C, Jarvelin MR, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kähönen M, Kantor DB, Karunas AS, Khusnutdinova E, Koppelman GH, Kozyrskyj AL, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee YA, Lehtimäki T, Letort S, Levin AM, Li G, Liang L, Loehr LR, London SJ, Loth DW, Manichaikul A, Marenholz I, Martinez FJ, Matheson MC, Mathias RA, Matsumoto K, Mbarek H, McArdle WL, Melbye M, Melén E, Meyers D, Michel S, Mohamdi H, Musk AW, Myers RA, Nieuwenhuis MAE, Noguchi E, O'Connor GT, Ogorodova LM, Palmer CD, Palotie A, Park JE, Pennell CE, Pershagen G, Polonikov A, Postma DS, Probst-Hensch N, Puzyrev VP, Raby BA, Raitakari OT, Ramasamy A, Rich SS, Robertson CF, Romieu I, Salam MT, Salomaa V, Schlünssen V, Scott R, Selivanova PA, Sigsgaard T, Simpson A, Siroux V, Smith LJ, Solodilova M, Standl M, Stefansson K, Strachan DP, Stricker BH, Takahashi A, Thompson PJ, Thorleifsson G, Thorsteinsdottir U, Tiesler CMT, Torgerson DG, Tsunoda T, Uitterlinden AG, van der Valk RJP, Vaysse A, Vedantam S, von Berg A, von Mutius E, Vonk JM, Waage J, Wareham NJ, Weiss ST, White WB, Wickman M, Widén E, Willemsen G, Williams LK, Wouters IM, Yang JJ, Zhao JH, Moffatt MF, Ober C, Nicolae DL. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018 01; 50(1):42-53. PMID: 29273806; PMCID: PMC5901974; DOI: 10.1038/s41588-017-0014-7;

Sorkness RL, Zoratti EM, Kattan M, Gergen PJ, Evans MD, Visness CM, Gill M, Khurana Hershey GK, Kercsmar CM, Liu AH, O'Connor GT, Pongracic JA, Pillai D, Sorkness CA, Togias A, Wood RA, Busse WW. Obstruction phenotype as a predictor of asthma severity and instability in children. J Allergy Clin Immunol. 2018 10; 142(4):1090-1099.e4. PMID: 29146272; PMCID: PMC5951738; DOI: 10.1016/j.jaci.2017.09.047;

Lee-Sarwar K, Hauser R, Calafat AM, Ye X, O'Connor GT, Sandel M, Bacharier LB, Zeiger RS, Laranjo N, Gold DR, Weiss ST, Litonjua AA, Savage JH. Prenatal and early-life triclosan and paraben exposure and allergic outcomes. J Allergy Clin Immunol. 2018 07; 142(1):269-278.e15.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 29111213; PMCID: PMC5924494; DOI: 10.1016/j.jaci.2017.09.029;

Willinger CM, Rong J, Tanriverdi K, Courchesne PL, Huan T, Wasserman GA, Lin H, Dupuis J, Joehanes R, Jones MR, Chen G, Benjamin EJ, O'Connor GT, Mizgerd JP, Freedman JE, Larson MG, Levy D. MicroRNA Signature of Cigarette Smoking and Evidence for a Putative Causal Role of MicroRNAs in Smoking-Related Inflammation and Target Organ Damage. Circ Cardiovasc Genet. 2017 Oct; 10(5).View Related Profiles.

Benjamin, Emelia
O'Connor, George
Wasserman, Gregory
Lin, Honghuang
Dupuis, Josee
Mizgerd, Joseph
Larson, Martin
Jones, Matthew

PMID: 29030400; PMCID: PMC5683429; DOI: 10.1161/CIRCGENETICS.116.001678;

O'Connor GT, Lynch SV, Bloomberg GR, Kattan M, Wood RA, Gergen PJ, Jaffee KF, Calatroni A, Bacharier LB, Beigelman A, Sandel MT, Johnson CC, Faruqi A, Santee C, Fujimura KE, Fadrosh D, Boushey H, Visness CM, Gern JE. Early-life home environment and risk of asthma among inner-city children. J Allergy Clin Immunol. 2018 04; 141(4):1468-1475.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 28939248; PMCID: PMC6521865; DOI: 10.1016/j.jaci.2017.06.040;

Mirzakhani H, Carey VJ, McElrath TF, Laranjo N, O'Connor G, Iverson RE, Lee-Parritz A, Strunk RC, Bacharier LB, Macones GA, Zeiger RS, Schatz M, Hollis BW, Litonjua AA, Weiss ST. The Association of Maternal Asthma and Early Pregnancy Vitamin D with Risk of Preeclampsia: An Observation From Vitamin D Antenatal Asthma Reduction Trial (VDAART). J Allergy Clin Immunol Pract. 2018 Mar - Apr; 6(2):600-608.e2.View Related Profiles.

Lee-Parritz, Aviva
O'Connor, George
Iverson, Ronald

PMID: 28923490; PMCID: PMC5843492; DOI: 10.1016/j.jaip.2017.07.018;

Savage JH, Lee-Sarwar KA, Sordillo J, Bunyavanich S, Zhou Y, O'Connor G, Sandel M, Bacharier LB, Zeiger R, Sodergren E, Weinstock GM, Gold DR, Weiss ST, Litonjua AA. A prospective microbiome-wide association study of food sensitization and food allergy in early childhood. Allergy. 2018 Jan; 73(1):145-152.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 28632934; PMCID: PMC5921051; DOI: 10.1111/all.13232;

Mirzakhani H, O'Connor G, Bacharier LB, Zeiger RS, Schatz MX, Weiss ST, Litonjua AA. Asthma control status in pregnancy, body mass index, and maternal vitamin D levels. J Allergy Clin Immunol. 2017 11; 140(5):1453-1456.e7. PMID: 28606587; PMCID: PMC5708874; DOI: 10.1016/j.jaci.2017.03.053;

Aschard H, Tobin MD, Hancock DB, Skurnik D, Sood A, James A, Vernon Smith A, Manichaikul AW, Campbell A, Prins BP, Hayward C, Loth DW, Porteous DJ, Strachan DP, Zeggini E, O'Connor GT, Brusselle GG, Boezen HM, Schulz H, Deary IJ, Hall IP, Rudan I, Kaprio J, Wilson JF, Wilk JB, Huffman JE, Hua Zhao J, de Jong K, Lyytikäinen LP, Wain LV, Jarvelin MR, Kähönen M, Fornage M, Polasek O, Cassano PA, Barr RG, Rawal R, Harris SE, Gharib SA, Enroth S, Heckbert SR, Lehtimäki T, Gyllensten U, Jackson VE, Gudnason V, Tang W, Dupuis J, Soler Artigas M, Joshi AD, London SJ, Kraft P. Evidence for large-scale gene-by-smoking interaction effects on pulmonary function. Int J Epidemiol. 2017 06 01; 46(3):894-904.View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 28082375; PMCID: PMC5837518; DOI: 10.1093/ije/dyw318;

Hornsby E, Pfeffer PE, Laranjo N, Cruikshank W, Tuzova M, Litonjua AA, Weiss ST, Carey VJ, O'Connor G, Hawrylowicz C. Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial. J Allergy Clin Immunol. 2018 01; 141(1):269-278.e1. PMID: 28552588

Manichaikul A, Wang XQ, Sun L, Dupuis J, Borczuk AC, Nguyen JN, Raghu G, Hoffman EA, Onengut-Gumuscu S, Farber EA, Kaufman JD, Rabinowitz D, Stukovsky KDH, Kawut SM, Hunninghake GM, Washko GR, O'Connor GT, Rich SS, Barr RG, Lederer DJ. Genome-wide association study of subclinical interstitial lung disease in MESA. Respir Res. 2017 May 18; 18(1):97.View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 28521775; PMCID: PMC5437638; DOI: 10.1186/s12931-017-0581-2;

Gold DR, Adamkiewicz G, Arshad SH, Celedón JC, Chapman MD, Chew GL, Cook DN, Custovic A, Gehring U, Gern JE, Johnson CC, Kennedy S, Koutrakis P, Leaderer B, Mitchell H, Litonjua AA, Mueller GA, O'Connor GT, Ownby D, Phipatanakul W, Persky V, Perzanowski MS, Ramsey CD, Salo PM, Schwaninger JM, Sordillo JE, Spira A, Suglia SF, Togias A, Zeldin DC, Matsui EC. NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management. J Allergy Clin Immunol. 2017 Oct; 140(4):933-949.View Related Profiles.

Spira, Avrum
O'Connor, George

PMID: 28502823; PMCID: PMC5632590; DOI: 10.1016/j.jaci.2017.04.024;

Araki T, Yanagawa M, Sun FJ, Dupuis J, Nishino M, Yamada Y, Washko GR, Christiani DC, Tomiyama N, O'Connor GT, Hunninghake GM, Hatabu H. Pleural abnormalities in the Framingham Heart Study: prevalence and CT image features. Occup Environ Med. 2017 Oct; 74(10):756-761.View Related Profiles.

Sun, Fangui
O'Connor, George
Dupuis, Josee

PMID: 28468931; PMCID: PMC5701783; DOI: 10.1136/oemed-2016-104178;

Lorbergs AL, O'Connor GT, Zhou Y, Travison TG, Kiel DP, Cupples LA, Rosen H, Samelson EJ. Severity of Kyphosis and Decline in Lung Function: The Framingham Study. J Gerontol A Biol Sci Med Sci. 2017 May 01; 72(5):689-694.View Related Profiles.

O'Connor, George
Cupples, L

PMID: 27341855; PMCID: PMC5964740; DOI: 10.1093/gerona/glw124;

Rota AP, Bacharier LB, Jaffee K, Visness CM, Kattan M, O'Connor GT, Wood RA, Gergen PJ, Gern JE, Bloomberg GR. Screen Time Engagement Is Increased in Urban Children With Asthma. Clin Pediatr (Phila). 2017 Oct; 56(11):1048-1053. PMID: 28871879; PMCID: PMC6378875; DOI: 10.1177/0009922817698801;

Wolsk HM, Harshfield BJ, Laranjo N, Carey VJ, O'Connor G, Sandel M, Strunk RC, Bacharier LB, Zeiger RS, Schatz M, Hollis BW, Weiss ST, Litonjua AA. Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: Secondary analyses from the Vitamin D Antenatal Asthma Reduction Trial. J Allergy Clin Immunol. 2017 Nov; 140(5):1423-1429.e5.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 28285844; DOI: 10.1016/j.jaci.2017.01.013;

Hardin M, Cho MH, Sharma S, Glass K, Castaldi PJ, McDonald ML, Aschard H, Senter-Sylvia J, Tantisira K, Weiss ST, Hersh CP, Morrow JD, Lomas D, Agusti A, Bakke P, Gulsvik A, O'Connor GT, Dupuis J, Hokanson J, Crapo JD, Beaty TH, Laird N, Silverman EK, DeMeo DL. Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. Am J Respir Cell Mol Biol. 2017 Mar; 56(3):332-341.View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 27854507; PMCID: PMC5359539; DOI: 10.1165/rcmb.2016-0172OC;

Hobbs BD, de Jong K, Lamontagne M, Bossé Y, Shrine N, Artigas MS, Wain LV, Hall IP, Jackson VE, Wyss AB, London SJ, North KE, Franceschini N, Strachan DP, Beaty TH, Hokanson JE, Crapo JD, Castaldi PJ, Chase RP, Bartz TM, Heckbert SR, Psaty BM, Gharib SA, Zanen P, Lammers JW, Oudkerk M, Groen HJ, Locantore N, Tal-Singer R, Rennard SI, Vestbo J, Timens W, Paré PD, Latourelle JC, Dupuis J, O'Connor GT, Wilk JB, Kim WJ, Lee MK, Oh YM, Vonk JM, de Koning HJ, Leng S, Belinsky SA, Tesfaigzi Y, Manichaikul A, Wang XQ, Rich SS, Barr RG, Sparrow D, Litonjua AA, Bakke P, Gulsvik A, Lahousse L, Brusselle GG, Stricker BH, Uitterlinden AG, Ampleford EJ, Bleecker ER, Woodruff PG, Meyers DA, Qiao D, Lomas DA, Yim JJ, Kim DK, Hawrylkiewicz I, Sliwinski P, Hardin M, Fingerlin TE, Schwartz DA, Postma DS, MacNee W, Tobin MD, Silverman EK, Boezen HM, Cho MH. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet. 2017 Mar; 49(3):426-432.View Related Profiles.

Sparrow, David
O'Connor, George
Latourelle, Jeanne
Dupuis, Josee

PMID: 28166215; PMCID: PMC5381275; DOI: 10.1038/ng.3752;

Hollingsworth HM, O'Connor GT. Asthma-Here Today, Gone Tomorrow? JAMA. 2017 01 17; 317(3):262-263.View Related Profiles.

O'Connor, George
Hollingsworth, Helen

PMID: 28114530; DOI: 10.1001/jama.2016.19676;

Gern JE, Calatroni A, Jaffee KF, Lynn H, Dresen A, Cruikshank WW, Lederman HM, Sampson HA, Shreffler W, Bacharier LB, Gergen PJ, Gold DR, Kattan M, O'Connor GT, Sandel MT, Wood RA, Bloomberg GR. Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy. J Allergy Clin Immunol. 2017 Sep; 140(3):836-844.e7.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 28089873; PMCID: PMC5509531; DOI: 10.1016/j.jaci.2016.10.052;

McDonald MN, Won S, Mattheisen M, Castaldi PJ, Cho MH, Rutten E, Hardin M, Yip WK, Rennard SI, Lomas DA, Wouters EFM, Agusti A, Casaburi R, Lange CP, O'Connor G, Hersh CP, Silverman EK. Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. J Cachexia Sarcopenia Muscle. 2017 Jun; 8(3):428-436. PMID: 28044437; PMCID: PMC5476850; DOI: 10.1002/jcsm.12171;

Dinakar Ch, O’Connor GT. The Health Effects of Electronic Cigarettes. N Engl J Med. 2016 12 29; 375(26):2608-2609. PMID: 28029910; DOI: 10.1056/NEJMc1613869;

Lu C, O'Connor GT, Dupuis J, Kolaczyk ED. Meta-Analysis for Penalized Regression Methods with Multi-Cohort Genome-Wide Association Studies. Hum Hered. 2016; 81(3):142-149.View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 28002817; PMCID: PMC5331116; DOI: 10.1159/000447969;

Araki T, Putman RK, Hatabu H, Gao W, Dupuis J, Latourelle JC, Nishino M, Zazueta OE, Kurugol S, Ross JC, San José Estépar R, Schwartz DA, Rosas IO, Washko GR, O'Connor GT, Hunninghake GM. Development and Progression of Interstitial Lung Abnormalities in the Framingham Heart Study. Am J Respir Crit Care Med. 2016 Dec 15; 194(12):1514-1522.View Related Profiles.

O'Connor, George
Latourelle, Jeanne
Dupuis, Josee

PMID: 27314401; PMCID: PMC5215030; DOI: 10.1164/rccm.201512-2523OC;

Mirzakhani H, Litonjua AA, McElrath TF, O'Connor G, Lee-Parritz A, Iverson R, Macones G, Strunk RC, Bacharier LB, Zeiger R, Hollis BW, Handy DE, Sharma A, Laranjo N, Carey V, Qiu W, Santolini M, Liu S, Chhabra D, Enquobahrie DA, Williams MA, Loscalzo J, Weiss ST. Early pregnancy vitamin D status and risk of preeclampsia. J Clin Invest. 2016 Dec 01; 126(12):4702-4715.View Related Profiles.

Lee-Parritz, Aviva
O'Connor, George
Iverson, Ronald

PMID: 27841759; PMCID: PMC5127689; DOI: 10.1172/JCI89031;

Huan T, Joehanes R, Schurmann C, Schramm K, Pilling LC, Peters MJ, Mägi R, DeMeo D, O'Connor GT, Ferrucci L, Teumer A, Homuth G, Biffar R, Völker U, Herder C, Waldenberger M, Peters A, Zeilinger S, Metspalu A, Hofman A, Uitterlinden AG, Hernandez DG, Singleton AB, Bandinelli S, Munson PJ, Lin H, Benjamin EJ, Esko T, Grabe HJ, Prokisch H, van Meurs JB, Melzer D, Levy D. A whole-blood transcriptome meta-analysis identifies gene expression signatures of cigarette smoking. Hum Mol Genet. 2016 11 01; 25(21):4611-4623.View Related Profiles.

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Sordillo JE, Zhou Y, McGeachie MJ, Ziniti J, Lange N, Laranjo N, Savage JR, Carey V, O'Connor G, Sandel M, Strunk R, Bacharier L, Zeiger R, Weiss ST, Weinstock G, Gold DR, Litonjua AA. Factors influencing the infant gut microbiome at age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART). J Allergy Clin Immunol. 2017 Feb; 139(2):482-491.e14.View Related Profiles.

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Dinakar C, O'Connor GT. The Health Effects of Electronic Cigarettes. N Engl J Med. 2016 Oct 06; 375(14):1372-1381. PMID: 27705269

Moses E, Wang T, Corbett S, Jackson GR, Drizik E, Perdomo C, Perdomo C, Kleerup E, Brooks D, O'Connor G, Dubinett S, Hayden P, Lenburg ME, Spira A. Molecular Impact of Electronic Cigarette Aerosol Exposure in Human Bronchial Epithelium. Toxicol Sci. 2017 Jan; 155(1):248-257.View Related Profiles.

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Liu AH, Babineau DC, Krouse RZ, Zoratti EM, Pongracic JA, O'Connor GT, Wood RA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Kattan M, Teach SJ, Makhija M, Pillai D, Lamm CI, Gern JE, Sigelman SM, Gergen PJ, Togias A, Visness CM, Busse WW. Pathways through which asthma risk factors contribute to asthma severity in inner-city children. J Allergy Clin Immunol. 2016 Oct; 138(4):1042-1050. PMID: 27720018; PMCID: PMC5381517; DOI: 10.1016/j.jaci.2016.06.060;

Zoratti EM, Krouse RZ, Babineau DC, Pongracic JA, O'Connor GT, Wood RA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Kattan M, Teach SJ, Sigelman SM, Gergen PJ, Togias A, Visness CM, Busse WW, Liu AH. Asthma phenotypes in inner-city children. J Allergy Clin Immunol. 2016 Oct; 138(4):1016-1029. PMID: 27720016; PMCID: PMC5104222; DOI: 10.1016/j.jaci.2016.06.061;

Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, Moreno-Macias H, Smith JA, Brody JA, Dhingra R, Yousefi P, Pankow JS, Kunze S, Shah SH, McRae AF, Lohman K, Sha J, Absher DM, Ferrucci L, Zhao W, Demerath EW, Bressler J, Grove ML, Huan T, Liu C, Mendelson MM, Yao C, Kiel DP, Peters A, Wang-Sattler R, Visscher PM, Wray NR, Starr JM, Ding J, Rodriguez CJ, Wareham NJ, Irvin MR, Zhi D, Barrdahl M, Vineis P, Ambatipudi S, Uitterlinden AG, Hofman A, Schwartz J, Colicino E, Hou L, Vokonas PS, Hernandez DG, Singleton AB, Bandinelli S, Turner ST, Ware EB, Smith AK, Klengel T, Binder EB, Psaty BM, Taylor KD, Gharib SA, Swenson BR, Liang L, DeMeo DL, O'Connor GT, Herceg Z, Ressler KJ, Conneely KN, Sotoodehnia N, Kardia SL, Melzer D, Baccarelli AA, van Meurs JB, Romieu I, Arnett DK, Ong KK, Liu Y, Waldenberger M, Deary IJ, Fornage M, Levy D, London SJ. Epigenetic Signatures of Cigarette Smoking. Circ Cardiovasc Genet. 2016 Oct; 9(5):436-447.View Related Profiles.

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Martinez FJ, O'Connor GT. Screening, Case-Finding, and Outcomes for Adults With Unrecognized COPD. JAMA. 2016 Apr 5; 315(13):1343-4. PMID: 27046363; DOI: 10.1001/jama.2016.3274;

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Kakumanu S, Jaffee K, Visness CM, Dresen A, Burger M, Witter FR, O'Connor GT, Cruikshank WW, Shreffler WG, Bacharier LB, Gern JE. The influence of atopy and asthma on immune responses in inner-city adults. Immun Inflamm Dis. 2016 Mar; 4(1):80-90. PMID: 27042305; PMCID: PMC4768071; DOI: 10.1002/iid3.96;

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Litonjua AA, Carey VJ, Laranjo N, Harshfield BJ, McElrath TF, O'Connor GT, Sandel M, Iverson RE, Lee-Paritz A, Strunk RC, Bacharier LB, Macones GA, Zeiger RS, Schatz M, Hollis BW, Hornsby E, Hawrylowicz C, Wu AC, Weiss ST. Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial. JAMA. 2016 Jan 26; 315(4):362-70.View Related Profiles.

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Gharib SA, Loth DW, Soler Artigas M, Birkland TP, Wilk JB, Wain LV, Brody JA, Obeidat M, Hancock DB, Tang W, Rawal R, Boezen HM, Imboden M, Huffman JE, Lahousse L, Alves AC, Manichaikul A, Hui J, Morrison AC, Ramasamy A, Smith AV, Gudnason V, Surakka I, Vitart V, Evans DM, Strachan DP, Deary IJ, Hofman A, Gläser S, Wilson JF, North KE, Zhao JH, Heckbert SR, Jarvis DL, Probst-Hensch N, Schulz H, Barr RG, Jarvelin MR, O'Connor GT, Kähönen M, Cassano PA, Hysi PG, Dupuis J, Hayward C, Psaty BM, Hall IP, Parks WC, Tobin MD, London SJ. Integrative pathway genomics of lung function and airflow obstruction. Hum Mol Genet. 2015 Dec 1; 24(23):6836-48.View Related Profiles.

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Obeidat M, Hao K, Bossé Y, Nickle DC, Nie Y, Postma DS, Laviolette M, Sandford AJ, Daley DD, Hogg JC, Elliott WM, Fishbane N, Timens W, Hysi PG, Kaprio J, Wilson JF, Hui J, Rawal R, Schulz H, Stubbe B, Hayward C, Polasek O, Järvelin MR, Zhao JH, Jarvis D, Kähönen M, Franceschini N, North KE, Loth DW, Brusselle GG, Smith AV, Gudnason V, Bartz TM, Wilk JB, O'Connor GT, Cassano PA, Tang W, Wain LV, Soler Artigas M, Gharib SA, Strachan DP, Sin DD, Tobin MD, London SJ, Hall IP, Paré PD. Molecular mechanisms underlying variations in lung function: a systems genetics analysis. Lancet Respir Med. 2015 Oct; 3(10):782-95. PMID: 26404118; PMCID: PMC5021067; DOI: 10.1016/S2213-2600(15)00380-X;

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Rice MB, Ljungman PL, Wilker EH, Dorans KS, Gold DR, Schwartz J, Koutrakis P, Washko GR, O'Connor GT, Mittleman MA. Long-term exposure to traffic emissions and fine particulate matter and lung function decline in the Framingham heart study. Am J Respir Crit Care Med. 2015 Mar 15; 191(6):656-64. PMID: 25590631; PMCID: PMC4384780; DOI: 10.1164/rccm.201410-1875OC;

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Coogan PF, Castro-Webb N, Yu J, O'Connor GT, Palmer JR, Rosenberg L. Active and passive smoking and the incidence of asthma in the Black Women's Health Study. Am J Respir Crit Care Med. 2015 Jan 15; 191(2):168-76.View Related Profiles.

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Gottlieb DJ, Hek K, Chen TH, Watson NF, Eiriksdottir G, Byrne EM, Cornelis M, Warby SC, Bandinelli S, Cherkas L, Evans DS, Grabe HJ, Lahti J, Li M, Lehtimäki T, Lumley T, Marciante KD, Pérusse L, Psaty BM, Robbins J, Tranah GJ, Vink JM, Wilk JB, Stafford JM, Bellis C, Biffar R, Bouchard C, Cade B, Curhan GC, Eriksson JG, Ewert R, Ferrucci L, Fülöp T, Gehrman PR, Goodloe R, Harris TB, Heath AC, Hernandez D, Hofman A, Hottenga JJ, Hunter DJ, Jensen MK, Johnson AD, Kähönen M, Kao L, Kraft P, Larkin EK, Lauderdale DS, Luik AI, Medici M, Montgomery GW, Palotie A, Patel SR, Pistis G, Porcu E, Quaye L, Raitakari O, Redline S, Rimm EB, Rotter JI, Smith AV, Spector TD, Teumer A, Uitterlinden AG, Vohl MC, Widen E, Willemsen G, Young T, Zhang X, Liu Y, Blangero J, Boomsma DI, Gudnason V, Hu F, Mangino M, Martin NG, O'Connor GT, Stone KL, Tanaka T, Viikari J, Gharib SA, Punjabi NM, Räikkönen K, Völzke H, Mignot E, Tiemeier H. Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. Mol Psychiatry. 2015 Oct; 20(10):1232-9.View Related Profiles.

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Dupuis, Josee

PMID: 24983941; PMCID: PMC4077649; DOI: 10.1371/journal.pone.0100776;

Loth DW, Artigas MS, Gharib SA, Wain LV, Franceschini N, Koch B, Pottinger TD, Smith AV, Duan Q, Oldmeadow C, Lee MK, Strachan DP, James AL, Huffman JE, Vitart V, Ramasamy A, Wareham NJ, Kaprio J, Wang XQ, Trochet H, Kähönen M, Flexeder C, Albrecht E, Lopez LM, de Jong K, Thyagarajan B, Alves AC, Enroth S, Omenaas E, Joshi PK, Fall T, Viñuela A, Launer LJ, Loehr LR, Fornage M, Li G, Wilk JB, Tang W, Manichaikul A, Lahousse L, Harris TB, North KE, Rudnicka AR, Hui J, Gu X, Lumley T, Wright AF, Hastie ND, Campbell S, Kumar R, Pin I, Scott RA, Pietiläinen KH, Surakka I, Liu Y, Holliday EG, Schulz H, Heinrich J, Davies G, Vonk JM, Wojczynski M, Pouta A, Johansson A, Wild SH, Ingelsson E, Rivadeneira F, Völzke H, Hysi PG, Eiriksdottir G, Morrison AC, Rotter JI, Gao W, Postma DS, White WB, Rich SS, Hofman A, Aspelund T, Couper D, Smith LJ, Psaty BM, Lohman K, Burchard EG, Uitterlinden AG, Garcia M, Joubert BR, McArdle WL, Musk AB, Hansel N, Heckbert SR, Zgaga L, van Meurs JB, Navarro P, Rudan I, Oh YM, Redline S, Jarvis DL, Zhao JH, Rantanen T, O'Connor GT, Ripatti S, Scott RJ, Karrasch S, Grallert H, Gaddis NC, Starr JM, Wijmenga C, Minster RL, Lederer DJ, Pekkanen J, Gyllensten U, Campbell H, Morris AP, Gläser S, Hammond CJ, Burkart KM, Beilby J, Kritchevsky SB, Gudnason V, Hancock DB, Williams OD, Polasek O, Zemunik T, Kolcic I, Petrini MF, Wjst M, Kim WJ, Porteous DJ, Scotland G, Smith BH, Viljanen A, Heliövaara M, Attia JR, Sayers I, Hampel R, Gieger C, Deary IJ, Boezen HM, Newman A, Jarvelin MR, Wilson JF, Lind L, Stricker BH, Teumer A, Spector TD, Melén E, Peters MJ, Lange LA, Barr RG, Bracke KR, Verhamme FM, Sung J, Hiemstra PS, Cassano PA, Sood A, Hayward C, Dupuis J, Hall IP, Brusselle GG, Tobin MD, London SJ. Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nat Genet. 2014 Jul; 46(7):669-77.View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 24929828; PMCID: PMC4140093; DOI: 10.1038/ng.3011;

Lynch SV, Wood RA, Boushey H, Bacharier LB, Bloomberg GR, Kattan M, O'Connor GT, Sandel MT, Calatroni A, Matsui E, Johnson CC, Lynn H, Visness CM, Jaffee KF, Gergen PJ, Gold DR, Wright RJ, Fujimura K, Rauch M, Busse WW, Gern JE. Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children. J Allergy Clin Immunol. 2014 Sep; 134(3):593-601.e12.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 24908147; PMCID: PMC4151305; DOI: 10.1016/j.jaci.2014.04.018;

Demehri S, Yockey LJ, Visness CM, Jaffee KF, Turkoz A, Wood RA, O'Connor GT, Kattan M, Gern JE, Gergen PJ, Holtzman M, Bloomberg G, Kopan R. Circulating TSLP associates with decreased wheezing in non-atopic preschool children: data from the URECA birth cohort. Clin Exp Allergy. 2014 Jun; 44(6):851-7. PMID: 24397611; PMCID: PMC4037448; DOI: 10.1111/cea.12270;

Litonjua AA, Lange NE, Carey VJ, Brown S, Laranjo N, Harshfield BJ, O'Connor GT, Sandel M, Strunk RC, Bacharier LB, Zeiger RS, Schatz M, Hollis BW, Weiss ST. The Vitamin D Antenatal Asthma Reduction Trial (VDAART): rationale, design, and methods of a randomized, controlled trial of vitamin D supplementation in pregnancy for the primary prevention of asthma and allergies in children. Contemp Clin Trials. 2014 May; 38(1):37-50.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 24614387; PMCID: PMC4086903; DOI: 10.1016/j.cct.2014.02.006;

Coogan PF, Yu J, O'Connor GT, Brown TA, Cozier YC, Palmer JR, Rosenberg L. Experiences of racism and the incidence of adult-onset asthma in the Black Women's Health Study. Chest. 2014 Mar 1; 145(3):480-5.View Related Profiles.

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Palmer, Julie
Rosenberg, Lynn
Coogan, Patricia
Cozier, Yvette

PMID: 23887828; PMCID: PMC3941245; DOI: 10.1378/chest.13-0665;

Cheng S, Enserro D, Xanthakis V, Sullivan LM, Murabito JM, Benjamin EJ, Polak JF, O'Donnell CJ, Wolf PA, O'Connor GT, Keaney JF, Vasan RS. Association of exhaled carbon monoxide with subclinical cardiovascular disease and their conjoint impact on the incidence of cardiovascular outcomes. Eur Heart J. 2014 Nov 7; 35(42):2980-7.View Related Profiles.

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Xanthakis, Vanessa
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PMID: 24574370; PMCID: PMC4271053; DOI: 10.1093/eurheartj/ehu052;

Manichaikul A, Hoffman EA, Smolonska J, Gao W, Cho MH, Baumhauer H, Budoff M, Austin JH, Washko GR, Carr JJ, Kaufman JD, Pottinger T, Powell CA, Wijmenga C, Zanen P, Groen HJ, Postma DS, Wanner A, Rouhani FN, Brantly ML, Powell R, Smith BM, Rabinowitz D, Raffel LJ, Hinckley Stukovsky KD, Crapo JD, Beaty TH, Hokanson JE, Silverman EK, Dupuis J, O'Connor GT, Boezen HM, Rich SS, Barr RG. Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. Am J Respir Crit Care Med. 2014 Feb 15; 189(4):408-18.View Related Profiles.

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Dupuis, Josee

PMID: 24383474; PMCID: PMC3977717; DOI: 10.1164/rccm.201306-1061OC;

Coogan PF, Yu J, O'Connor GT, Brown TA, Palmer JR, Rosenberg L. Depressive symptoms and the incidence of adult-onset asthma in African American women. Ann Allergy Asthma Immunol. 2014 Apr; 112(4):333-8.e1.View Related Profiles.

O'Connor, George
Palmer, Julie
Rosenberg, Lynn
Coogan, Patricia

PMID: 24440322; PMCID: PMC3972352; DOI: 10.1016/j.anai.2013.12.025;

Rice MB, Ljungman PL, Wilker EH, Gold DR, Schwartz JD, Koutrakis P, Washko GR, O'Connor GT, Mittleman MA. Short-term exposure to air pollution and lung function in the Framingham Heart Study. Am J Respir Crit Care Med. 2013 Dec 1; 188(11):1351-7. PMID: 24200465; PMCID: PMC3919078; DOI: 10.1164/rccm.201308-1414OC;

Reardon BJ, Hansen JG, Crystal RG, Houston DK, Kritchevsky SB, Harris T, Lohman K, Liu Y, O'Connor GT, Wilk JB, Mezey J, Gao C, Cassano PA. Vitamin D-responsive SGPP2 variants associated with lung cell expression and lung function. BMC Med Genet. 2013; 14:122. PMID: 24274704; PMCID: PMC3907038; DOI: 10.1186/1471-2350-14-122;

Wood RA, Togias A, Wildfire J, Visness CM, Matsui EC, Gruchalla R, Hershey G, Liu AH, O'Connor GT, Pongracic JA, Zoratti E, Little F, Granada M, Kennedy S, Durham SR, Shamji MH, Busse WW. Development of cockroach immunotherapy by the Inner-City Asthma Consortium. J Allergy Clin Immunol. 2014 Mar; 133(3):846-52.e6. PMID: 24184147; PMCID: PMC3943647; DOI: 10.1016/j.jaci.2013.08.047;

Rosenquist KJ, Massaro JM, Pencina KM, D'Agostino RB, Beiser A, O'Connor GT, O'Donnell CJ, Wolf PA, Polak JF, Seshadri S, Fox CS. Neck circumference, carotid wall intima-media thickness, and incident stroke. Diabetes Care. 2013 Sep; 36(9):e153-4.View Related Profiles.

Beiser, Alexa
O'Donnell, Christopher
O'Connor, George
Massaro, Joseph
Polak, Joseph
Wolf, Philip
D'Agostino, Ralph
Seshadri, Sudha

PMID: 23970728; PMCID: PMC3747939; DOI: 10.2337/dc13-0379;

Burkart KM, Manichaikul A, Wilk JB, Ahmed FS, Burke GL, Enright P, Hansel NN, Haynes D, Heckbert SR, Hoffman EA, Kaufman JD, Kurai J, Loehr L, London SJ, Meng Y, O'Connor GT, Oelsner E, Petrini M, Pottinger TD, Powell CA, Redline S, Rotter JI, Smith LJ, Soler Artigas M, Tobin MD, Tsai MY, Watson K, White W, Young TR, Rich SS, Barr RG. APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema. Eur Respir J. 2014 Apr; 43(4):1003-17. PMID: 23900982; PMCID: PMC4041087; DOI: 10.1183/09031936.00147612;

Bethea TN, Rosenberg L, Charlot M, O'Connor GT, Adams-Campbell LL, Palmer JR. Obesity in relation to lung cancer incidence in African American women. Cancer Causes Control. 2013 Sep; 24(9):1695-703.View Related Profiles.

O'Connor, George
Palmer, Julie
Rosenberg, Lynn
Charlot, Marjory
Bethea, Traci

PMID: 23744044; PMCID: PMC3737410; DOI: 10.1007/s10552-013-0245-6;

Hunninghake GM, Hatabu H, Okajima Y, Gao W, Dupuis J, Latourelle JC, Nishino M, Araki T, Zazueta OE, Kurugol S, Ross JC, San José Estépar R, Murphy E, Steele MP, Loyd JE, Schwarz MI, Fingerlin TE, Rosas IO, Washko GR, O'Connor GT, Schwartz DA. MUC5B promoter polymorphism and interstitial lung abnormalities. N Engl J Med. 2013 Jun 6; 368(23):2192-200.View Related Profiles.

O'Connor, George
Latourelle, Jeanne
Dupuis, Josee

PMID: 23692170; PMCID: PMC3747636; DOI: 10.1056/NEJMoa1216076;

Kantor DB, Palmer CD, Young TR, Meng Y, Gajdos ZK, Lyon H, Price AL, Pollack S, London SJ, Loehr LR, Smith LJ, Kumar R, Jacobs DR, Petrini MF, O'Connor GT, White WB, Papanicolaou G, Burkart KM, Heckbert SR, Barr RG, Hirschhorn JN. Replication and fine mapping of asthma-associated loci in individuals of African ancestry. Hum Genet. 2013 Sep; 132(9):1039-47. PMID: 23666277; PMCID: PMC3975655; DOI: 10.1007/s00439-013-1310-7;

Chami HA, Fontes JD, Vasan RS, Keaney JF, O'Connor GT, Larson MG, Benjamin EJ, Gottlieb DJ. Vascular inflammation and sleep disordered breathing in a community-based cohort. Sleep. 2013 May; 36(5):763-768C.View Related Profiles.

Benjamin, Emelia
O'Connor, George
Larson, Martin
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PMID: 23633759; PMCID: PMC3622647; DOI: 10.5665/sleep.2644;

Steiling K, van den Berge M, Hijazi K, Florido R, Campbell J, Liu G, Xiao J, Zhang X, Duclos G, Drizik E, Si H, Perdomo C, Dumont C, Coxson HO, Alekseyev YO, Sin D, Pare P, Hogg JC, McWilliams A, Hiemstra PS, Sterk PJ, Timens W, Chang JT, Sebastiani P, O'Connor GT, Bild AH, Postma DS, Lam S, Spira A, Lenburg ME. A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med. 2013 May 1; 187(9):933-42.View Related Profiles.

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Dumont, Charles
Liu, Gang
O'Connor, George
Duclos, Grant
Campbell, Joshua
Steiling, Katrina
Lenburg, Marc
Sebastiani, Paola
Alekseyev, Yuriy

PMID: 23471465; PMCID: PMC3707363; DOI: 10.1164/rccm.201208-1449OC;

Lu C, Latourelle J, O'Connor GT, Dupuis J, Kolaczyk ED. Network-guided sparse regression modeling for detection of gene-by-gene interactions. Bioinformatics. 2013 May 15; 29(10):1241-9.View Related Profiles.

O'Connor, George
Latourelle, Jeanne
Dupuis, Josee

PMID: 23599501; PMCID: PMC3711507; DOI: 10.1093/bioinformatics/btt139;

Gergen PJ, Teach SJ, Mitchell HE, Freishtat RF, Calatroni A, Matsui E, Kattan M, Bloomberg GR, Liu AH, Kercsmar C, O'Connor G, Pongracic J, Rivera-Sanchez Y, Morgan WJ, Sorkness CA, Binkley N, Busse W. Lack of a relation between serum 25-hydroxyvitamin D concentrations and asthma in adolescents. Am J Clin Nutr. 2013 Jun; 97(6):1228-34. PMID: 23595876; PMCID: PMC3652921; DOI: 10.3945/ajcn.112.046961;

Oelsner EC, Pottinger TD, Burkart KM, Allison M, Buxbaum SG, Hansel NN, Kumar R, Larkin EK, Lange LA, Loehr LR, London SJ, O'Connor GT, Papanicolaou G, Petrini MF, Rabinowitz D, Raghavan S, Redline S, Thyagarajan B, Tracy RP, Wilk JB, White WB, Rich SS, Barr RG. Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts. Biomarkers. 2013 May; 18(3):196-203. PMID: 23557128; PMCID: PMC3890095; DOI: 10.3109/1354750X.2012.762805;

Ramasamy A, Kuokkanen M, Vedantam S, Gajdos ZK, Couto Alves A, Lyon HN, Ferreira MAR, Strachan DP, Zhao JH, Abramson MJ, Brown MA, Coin L, Dharmage SC, Duffy DL, Haahtela T, Heath AC, Janson C, Kähönen M, Khaw KT, Laitinen J, Le Souef P, Lehtimäki T, Madden PAF, Marks GB, Martin NG, Matheson MC, Palmer CD, Palotie A, Pouta A, Robertson CF, Viikari J, Widen E, Wjst M, Jarvis DL, Montgomery GW, Thompson PJ, Wareham N, Eriksson J, Jousilahti P, Laitinen T, Pekkanen J, Raitakari OT, O'Connor GT, Salomaa V, Jarvelin MR, Hirschhorn JN. Correction: Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA. PLoS One. 2013; 8(3). PMID: 29294486; PMCID: PMC6061579; DOI: 10.1371/annotation/9630862b-4676-4b82-9869-8d8fbb2a2e65;

Sorkness CA, Wildfire JJ, Calatroni A, Mitchell HE, Busse WW, O'Connor GT, Pongracic JA, Ross K, Gill MA, Kattan M, Morgan WJ, Teach SJ, Gergen PJ, Liu AH, Szefler SJ. Reassessment of omalizumab-dosing strategies and pharmacodynamics in inner-city children and adolescents. J Allergy Clin Immunol Pract. 2013 Mar; 1(2):163-71. PMID: 24565455; PMCID: PMC4254887; DOI: 10.1016/j.jaip.2013.01.011;

Hancock DB, Artigas MS, Gharib SA, Henry A, Manichaikul A, Ramasamy A, Loth DW, Imboden M, Koch B, McArdle WL, Smith AV, Smolonska J, Sood A, Tang W, Wilk JB, Zhai G, Zhao JH, Aschard H, Burkart KM, Curjuric I, Eijgelsheim M, Elliott P, Gu X, Harris TB, Janson C, Homuth G, Hysi PG, Liu JZ, Loehr LR, Lohman K, Loos RJ, Manning AK, Marciante KD, Obeidat M, Postma DS, Aldrich MC, Brusselle GG, Chen TH, Eiriksdottir G, Franceschini N, Heinrich J, Rotter JI, Wijmenga C, Williams OD, Bentley AR, Hofman A, Laurie CC, Lumley T, Morrison AC, Joubert BR, Rivadeneira F, Couper DJ, Kritchevsky SB, Liu Y, Wjst M, Wain LV, Vonk JM, Uitterlinden AG, Rochat T, Rich SS, Psaty BM, O'Connor GT, North KE, Mirel DB, Meibohm B, Launer LJ, Khaw KT, Hartikainen AL, Hammond CJ, Gläser S, Marchini J, Kraft P, Wareham NJ, Völzke H, Stricker BH, Spector TD, Probst-Hensch NM, Jarvis D, Jarvelin MR, Heckbert SR, Gudnason V, Boezen HM, Barr RG, Cassano PA, Strachan DP, Fornage M, Hall IP, Dupuis J, Tobin MD, London SJ. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genet. 2012; 8(12):e1003098.View Related Profiles.

O'Connor, George
Dupuis, Josee

PMID: 23284291; PMCID: PMC3527213; DOI: 10.1371/journal.pgen.1003098;

Coogan PF, Wise LA, O'Connor GT, Brown TA, Palmer JR, Rosenberg L. Abuse during childhood and adolescence and risk of adult-onset asthma in African American women. J Allergy Clin Immunol. 2013 Apr; 131(4):1058-63.View Related Profiles.

O'Connor, George
Palmer, Julie
Wise, Lauren
Rosenberg, Lynn
Coogan, Patricia

PMID: 23219171; PMCID: PMC3615035; DOI: 10.1016/j.jaci.2012.10.023;

Coglianese EE, Larson MG, Vasan RS, Ho JE, Ghorbani A, McCabe EL, Cheng S, Fradley MG, Kretschman D, Gao W, O'Connor G, Wang TJ, Januzzi JL. Distribution and clinical correlates of the interleukin receptor family member soluble ST2 in the Framingham Heart Study. Clin Chem. 2012 Dec; 58(12):1673-81.View Related Profiles.

O'Connor, George
Ho, Jennifer
Larson, Martin
Ramachandran, Vasan

PMID: 23065477; PMCID: PMC3557515; DOI: 10.1373/clinchem.2012.192153;

Ramasamy A, Kuokkanen M, Vedantam S, Gajdos ZK, Couto Alves A, Lyon HN, Ferreira MA, Strachan DP, Zhao JH, Abramson MJ, Brown MA, Coin L, Dharmage SC, Duffy DL, Haahtela T, Heath AC, Janson C, Kähönen M, Khaw KT, Laitinen J, Le Souef P, Lehtimäki T, Madden PA, Marks GB, Martin NG, Matheson MC, Palmer CD, Palotie A, Pouta A, Robertson CF, Viikari J, Widen E, Wjst M, Jarvis DL, Montgomery GW, Thompson PJ, Wareham N, Eriksson J, Jousilahti P, Laitinen T, Pekkanen J, Raitakari OT, O'Connor GT, Salomaa V, Jarvelin MR, Hirschhorn JN. Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. PLoS One. 2012; 7(9):e44008. PMID: 23028483; PMCID: PMC3461045; DOI: 10.1371/journal.pone.0044008;

Hansel NN, Ruczinski I, Rafaels N, Sin DD, Daley D, Malinina A, Huang L, Sandford A, Murray T, Kim Y, Vergara C, Heckbert SR, Psaty BM, Li G, Elliott WM, Aminuddin F, Dupuis J, O'Connor GT, Doheny K, Scott AF, Boezen HM, Postma DS, Smolonska J, Zanen P, Mohamed Hoesein FA, de Koning HJ, Crystal RG, Tanaka T, Ferrucci L, Silverman E, Wan E, Vestbo J, Lomas DA, Connett J, Wise RA, Neptune ER, Mathias RA, Paré PD, Beaty TH, Barnes KC. Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD. Hum Genet. 2013 Jan; 132(1):79-90.View Related Profiles.

Wan, Emily
O'Connor, George
Dupuis, Josee

PMID: 22986903; PMCID: PMC3536920; DOI: 10.1007/s00439-012-1219-6;

O'Connor GT, Reibman J. Inhaled corticosteroid dose adjustment in mild persistent asthma. JAMA. 2012 Sep 12; 308(10):1036-7. PMID: 22968893; DOI: 10.1001/2012.jama.11405;

Wilk JB, Shrine NR, Loehr LR, Zhao JH, Manichaikul A, Lopez LM, Smith AV, Heckbert SR, Smolonska J, Tang W, Loth DW, Curjuric I, Hui J, Cho MH, Latourelle JC, Henry AP, Aldrich M, Bakke P, Beaty TH, Bentley AR, Borecki IB, Brusselle GG, Burkart KM, Chen TH, Couper D, Crapo JD, Davies G, Dupuis J, Franceschini N, Gulsvik A, Hancock DB, Harris TB, Hofman A, Imboden M, James AL, Khaw KT, Lahousse L, Launer LJ, Litonjua A, Liu Y, Lohman KK, Lomas DA, Lumley T, Marciante KD, McArdle WL, Meibohm B, Morrison AC, Musk AW, Myers RH, North KE, Postma DS, Psaty BM, Rich SS, Rivadeneira F, Rochat T, Rotter JI, Artigas MS, Starr JM, Uitterlinden AG, Wareham NJ, Wijmenga C, Zanen P, Province MA, Silverman EK, Deary IJ, Palmer LJ, Cassano PA, Gudnason V, Barr RG, Loos RJ, Strachan DP, London SJ, Boezen HM, Probst-Hensch N, Gharib SA, Hall IP, O'Connor GT, Tobin MD, Stricker BH. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med. 2012 Oct 1; 186(7):622-32.View Related Profiles.

O'Connor, George
Latourelle, Jeanne
Dupuis, Josee
Myers, Richard

PMID: 22837378; PMCID: PMC3480517; DOI: 10.1164/rccm.201202-0366OC;

O'Connor GT, Hatabu H. Lung cancer screening, radiation, risks, benefits, and uncertainty. JAMA. 2012 Jun 13; 307(22):2434-5. PMID: 22692175; DOI: 10.1001/jama.2012.6096;

Imboden M, Bouzigon E, Curjuric I, Ramasamy A, Kumar A, Hancock DB, Wilk JB, Vonk JM, Thun GA, Siroux V, Nadif R, Monier F, Gonzalez JR, Wjst M, Heinrich J, Loehr LR, Franceschini N, North KE, Altmüller J, Koppelman GH, Guerra S, Kronenberg F, Lathrop M, Moffatt MF, O'Connor GT, Strachan DP, Postma DS, London SJ, Schindler C, Kogevinas M, Kauffmann F, Jarvis DL, Demenais F, Probst-Hensch NM. Genome-wide association study of lung function decline in adults with and without asthma. J Allergy Clin Immunol. 2012 May; 129(5):1218-28. PMID: 22424883; PMCID: PMC3340499; DOI: 10.1016/j.jaci.2012.01.074;

Tepper RS, Wise RS, Covar R, Irvin CG, Kercsmar CM, Kraft M, Liu MC, O'Connor GT, Peters SP, Sorkness R, Togias A. Asthma outcomes: pulmonary physiology. J Allergy Clin Immunol. 2012 Mar; 129(3 Suppl):S65-87. PMID: 22386510; PMCID: PMC4263032; DOI: 10.1016/j.jaci.2011.12.986;

Granada M, Wilk JB, Tuzova M, Strachan DP, Weidinger S, Albrecht E, Gieger C, Heinrich J, Himes BE, Hunninghake GM, Celedón JC, Weiss ST, Cruikshank WW, Farrer LA, Center DM, O'Connor GT. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. J Allergy Clin Immunol. 2012 Mar; 129(3):840-845.e21.View Related Profiles.

Center, David
O'Connor, George
Farrer, Lindsay
Tuzova, Marina
Cruikshank, William

PMID: 22075330; PMCID: PMC3293994; DOI: 10.1016/j.jaci.2011.09.029;

Norweg A, Ni P, Garshick E, O'Connor G, Wilke K, Jette AM. A multidimensional computer adaptive test approach to dyspnea assessment. Arch Phys Med Rehabil. 2011 Oct; 92(10):1561-9.View Related Profiles.

Jette, Alan
Garshick, Eric
O'Connor, George
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PMID: 21963123; PMCID: PMC3526016; DOI: 10.1016/j.apmr.2011.05.020;

Soler Artigas M, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, Zhai G, Zhao JH, Smith AV, Huffman JE, Albrecht E, Jackson CM, Evans DM, Cadby G, Fornage M, Manichaikul A, Lopez LM, Johnson T, Aldrich MC, Aspelund T, Barroso I, Campbell H, Cassano PA, Couper DJ, Eiriksdottir G, Franceschini N, Garcia M, Gieger C, Gislason GK, Grkovic I, Hammond CJ, Hancock DB, Harris TB, Ramasamy A, Heckbert SR, Heliövaara M, Homuth G, Hysi PG, James AL, Jankovic S, Joubert BR, Karrasch S, Klopp N, Koch B, Kritchevsky SB, Launer LJ, Liu Y, Loehr LR, Lohman K, Loos RJ, Lumley T, Al Balushi KA, Ang WQ, Barr RG, Beilby J, Blakey JD, Boban M, Boraska V, Brisman J, Britton JR, Brusselle GG, Cooper C, Curjuric I, Dahgam S, Deary IJ, Ebrahim S, Eijgelsheim M, Francks C, Gaysina D, Granell R, Gu X, Hankinson JL, Hardy R, Harris SE, Henderson J, Henry A, Hingorani AD, Hofman A, Holt PG, Hui J, Hunter ML, Imboden M, Jameson KA, Kerr SM, Kolcic I, Kronenberg F, Liu JZ, Marchini J, McKeever T, Morris AD, Olin AC, Porteous DJ, Postma DS, Rich SS, Ring SM, Rivadeneira F, Rochat T, Sayer AA, Sayers I, Sly PD, Smith GD, Sood A, Starr JM, Uitterlinden AG, Vonk JM, Wannamethee SG, Whincup PH, Wijmenga C, Williams OD, Wong A, Mangino M, Marciante KD, McArdle WL, Meibohm B, Morrison AC, North KE, Omenaas E, Palmer LJ, Pietiläinen KH, Pin I, Pola Sbreve Ek O, Pouta A, Psaty BM, Hartikainen AL, Rantanen T, Ripatti S, Rotter JI, Rudan I, Rudnicka AR, Schulz H, Shin SY, Spector TD, Surakka I, Vitart V, Völzke H, Wareham NJ, Warrington NM, Wichmann HE, Wild SH, Wilk JB, Wjst M, Wright AF, Zgaga L, Zemunik T, Pennell CE, Nyberg F, Kuh D, Holloway JW, Boezen HM, Lawlor DA, Morris RW, Probst-Hensch N, Kaprio J, Wilson JF, Hayward C, Kähönen M, Heinrich J, Musk AW, Jarvis DL, Gläser S, Järvelin MR, Ch Stricker BH, Elliott P, O'Connor GT, Strachan DP, London SJ, Hall IP, Gudnason V, Tobin MD. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet. 2011 Nov; 43(11):1082-90. PMID: 21946350; PMCID: PMC3267376; DOI: 10.1038/ng.941;

Mendonça NT, Kenyon J, LaPrad AS, Syeda SN, O'Connor GT, Lutchen KR. Airway resistance at maximum inhalation as a marker of asthma and airway hyperresponsiveness. Respir Res. 2011; 12:96.View Related Profiles.

O'Connor, George
Lutchen, Kenneth
Syeda, Sohera

PMID: 21762517; PMCID: PMC3143926; DOI: 10.1186/1465-9921-12-96;

Chi A, Wildfire J, McLoughlin R, Wood RA, Bloomberg GR, Kattan M, Gergen P, Gold DR, Witter F, Chen T, Holick M, Visness C, Gern J, O'Connor GT. Umbilical cord plasma 25-hydroxyvitamin D concentration and immune function at birth: the Urban Environment and Childhood Asthma study. Clin Exp Allergy. 2011 Jun; 41(6):842-50.View Related Profiles.

O'Connor, George
Holick, Michael
Chen, Tai

PMID: 21481021; PMCID: PMC3093441; DOI: 10.1111/j.1365-2222.2011.03712.x;

Bunyavanich S, Melen E, Wilk JB, Granada M, Soto-Quiros ME, Avila L, Lasky-Su J, Hunninghake GM, Wickman M, Pershagen G, O'Connor GT, Weiss ST, Celedón JC. Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma. Clin Mol Allergy. 2011; 9:1. PMID: 21244681; PMCID: PMC3032752; DOI: 10.1186/1476-7961-9-1;

Hunninghake GM, Soto-Quirós ME, Avila L, Kim HP, Lasky-Su J, Rafaels N, Ruczinski I, Beaty TH, Mathias RA, Barnes KC, Wilk JB, O'Connor GT, Gauderman WJ, Vora H, Baurley JW, Gilliland F, Liang C, Sylvia JS, Klanderman BJ, Sharma SS, Himes BE, Bossley CJ, Israel E, Raby BA, Bush A, Choi AM, Weiss ST, Celedón JC. TSLP polymorphisms are associated with asthma in a sex-specific fashion. Allergy. 2010 Dec; 65(12):1566-75. PMID: 20560908; PMCID: PMC2970693; DOI: 10.1111/j.1398-9995.2010.02415.x;

DeWan AT, Triche EW, Xu X, Hsu LI, Zhao C, Belanger K, Hellenbrand K, Willis-Owen SA, Moffatt M, Cookson WO, Himes BE, Weiss ST, Gauderman WJ, Baurley JW, Gilliland F, Wilk JB, O'Connor GT, Strachan DP, Hoh J, Bracken MB. PDE11A associations with asthma: results of a genome-wide association scan. J Allergy Clin Immunol. 2010 Oct; 126(4):871-873.e9. PMID: 20920776; PMCID: PMC3133448; DOI: 10.1016/j.jaci.2010.06.051;

Cheng S, Lyass A, Massaro JM, O'Connor GT, Keaney JF, Vasan RS. Exhaled carbon monoxide and risk of metabolic syndrome and cardiovascular disease in the community. Circulation. 2010 Oct 12; 122(15):1470-7.View Related Profiles.

O'Connor, George
Massaro, Joseph
Ramachandran, Vasan

PMID: 20876437; PMCID: PMC2975571; DOI: 10.1161/CIRCULATIONAHA.110.941013;

Himes BE, Lasky-Su J, Wu AC, Wilk JB, Hunninghake GM, Klanderman B, Murphy AJ, Lazarus R, Soto-Quiros ME, Avila L, Celedón JC, Lange C, O'Connor GT, Raby BA, Silverman EK, Weiss ST. Asthma-susceptibility variants identified using probands in case-control and family-based analyses. BMC Med Genet. 2010; 11:122. PMID: 20698975; PMCID: PMC2927535; DOI: 10.1186/1471-2350-11-122;

Gottlieb DJ, Yenokyan G, Newman AB, O'Connor GT, Punjabi NM, Quan SF, Redline S, Resnick HE, Tong EK, Diener-West M, Shahar E. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation. 2010 Jul 27; 122(4):352-60.View Related Profiles.

Gottlieb, Daniel
O'Connor, George

PMID: 20625114; PMCID: PMC3117288; DOI: 10.1161/CIRCULATIONAHA.109.901801;

Zanobetti A, Redline S, Schwartz J, Rosen D, Patel S, O'Connor GT, Lebowitz M, Coull BA, Gold DR. Associations of PM10 with sleep and sleep-disordered breathing in adults from seven U.S. urban areas. Am J Respir Crit Care Med. 2010 Sep 15; 182(6):819-25. PMID: 20508218; PMCID: PMC2949406; DOI: 10.1164/rccm.200912-1797OC;

Redline S, Yenokyan G, Gottlieb DJ, Shahar E, O'Connor GT, Resnick HE, Diener-West M, Sanders MH, Wolf PA, Geraghty EM, Ali T, Lebowitz M, Punjabi NM. Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med. 2010 Jul 15; 182(2):269-77.View Related Profiles.

Gottlieb, Daniel
O'Connor, George
Wolf, Philip

PMID: 20339144; PMCID: PMC2913239; DOI: 10.1164/rccm.200911-1746OC;

Pongracic JA, O'Connor GT, Muilenberg ML, Vaughn B, Gold DR, Kattan M, Morgan WJ, Gruchalla RS, Smartt E, Mitchell HE. Differential effects of outdoor versus indoor fungal spores on asthma morbidity in inner-city children. J Allergy Clin Immunol. 2010 Mar; 125(3):593-9. PMID: 20132971; PMCID: PMC4754109; DOI: 10.1016/j.jaci.2009.10.036;

Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD, Franceschini N, van Durme YM, Chen TH, Barr RG, Schabath MB, Couper DJ, Brusselle GG, Psaty BM, van Duijn CM, Rotter JI, Uitterlinden AG, Hofman A, Punjabi NM, Rivadeneira F, Morrison AC, Enright PL, North KE, Heckbert SR, Lumley T, Stricker BH, O'Connor GT, London SJ. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet. 2010 Jan; 42(1):45-52. PMID: 20010835; PMCID: PMC2832852; DOI: 10.1038/ng.500;

Zhang X, Sebastiani P, Liu G, Schembri F, Zhang X, Dumas YM, Langer EM, Alekseyev Y, O'Connor GT, Brooks DR, Lenburg ME, Spira A. Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium. Physiol Genomics. 2010 Mar 3; 41(1):1-8.View Related Profiles.

Spira, Avrum
Brooks, Daniel
Schembri, Frank
Liu, Gang
O'Connor, George
Lenburg, Marc
Sebastiani, Paola
Zhang, Xiaoling
Alekseyev, Yuriy
Dumas, Yves-Martine

PMID: 19952278; PMCID: PMC2841495; DOI: 10.1152/physiolgenomics.00167.2009;

Won S, Wilk JB, Mathias RA, O'Donnell CJ, Silverman EK, Barnes K, O'Connor GT, Weiss ST, Lange C. On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies. PLoS Genet. 2009 Nov; 5(11):e1000741.View Related Profiles.

O'Donnell, Christopher
O'Connor, George

PMID: 19956679; PMCID: PMC2777973; DOI: 10.1371/journal.pgen.1000741;

D'Armiento JM, Scharf SM, Roth MD, Connett JE, Ghio A, Sternberg D, Goldin JG, Louis TA, Mao JT, O'Connor GT, Ramsdell JW, Ries AL, Schluger NW, Sciurba FC, Skeans MA, Voelker H, Walter RE, Wendt CH, Weinmann GG, Wise RA, Foronjy RF. Eosinophil and T cell markers predict functional decline in COPD patients. Respir Res. 2009; 10:113. PMID: 19925666; PMCID: PMC2785783; DOI: 10.1186/1465-9921-10-113;

Chami HA, Keyes MJ, Vita JA, Mitchell GF, Larson MG, Fan S, Vasan RS, O'Connor GT, Benjamin EJ, Gottlieb DJ. Brachial artery diameter, blood flow and flow-mediated dilation in sleep-disordered breathing. Vasc Med. 2009 Nov; 14(4):351-60.View Related Profiles.

Gottlieb, Daniel
Benjamin, Emelia
O'Connor, George
Vita, Joseph
Larson, Martin
Ramachandran, Vasan

PMID: 19808720; PMCID: PMC2956304; DOI: 10.1177/1358863X09105132;

Gold DR, Bloomberg GR, Cruikshank WW, Visness CM, Schwarz J, Kattan M, O'Connor GT, Wood RA, Burger MS, Wright RJ, Witter F, Lee-Parritz A, Sperling R, Sadovsky Y, Togias A, Gern JE. Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses. J Allergy Clin Immunol. 2009 Nov; 124(5):1078-87.View Related Profiles.

Lee-Parritz, Aviva
O'Connor, George
Cruikshank, William

PMID: 19895995; PMCID: PMC2796683; DOI: 10.1016/j.jaci.2009.08.021;

Punjabi NM, Caffo BS, Goodwin JL, Gottlieb DJ, Newman AB, O'Connor GT, Rapoport DM, Redline S, Resnick HE, Robbins JA, Shahar E, Unruh ML, Samet JM. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med. 2009 Aug; 6(8):e1000132.View Related Profiles.

Gottlieb, Daniel
O'Connor, George

PMID: 19688045; PMCID: PMC2722083; DOI: 10.1371/journal.pmed.1000132;

Ly NP, Ruiz-Perez B, McLoughlin RM, Visness CM, Wallace PK, Cruikshank WW, Tzianabos AO, O'Connor GT, Gold DR, Gern JE. Characterization of regulatory T cells in urban newborns. Clin Mol Allergy. 2009; 7:8.View Related Profiles.

O'Connor, George
Cruikshank, William

PMID: 19586545; PMCID: PMC2717905; DOI: 10.1186/1476-7961-7-8;

O'Connor G, McNamara B. An audit of traumatic nerve injury. Ir Med J. 2009 Jul-Aug; 102(7):231-2. PMID: 19772010

Gern JE, Visness CM, Gergen PJ, Wood RA, Bloomberg GR, O'Connor GT, Kattan M, Sampson HA, Witter FR, Sandel MT, Shreffler WG, Wright RJ, Arbes SJ, Busse WW. The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population. BMC Pulm Med. 2009; 9:17.View Related Profiles.

O'Connor, George
Sandel, Megan

PMID: 19426496; PMCID: PMC2689166; DOI: 10.1186/1471-2466-9-17;

Himes BE, Hunninghake GM, Baurley JW, Rafaels NM, Sleiman P, Strachan DP, Wilk JB, Willis-Owen SA, Klanderman B, Lasky-Su J, Lazarus R, Murphy AJ, Soto-Quiros ME, Avila L, Beaty T, Mathias RA, Ruczinski I, Barnes KC, Celedón JC, Cookson WO, Gauderman WJ, Gilliland FD, Hakonarson H, Lange C, Moffatt MF, O'Connor GT, Raby BA, Silverman EK, Weiss ST. Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet. 2009 May; 84(5):581-93. PMID: 19426955; PMCID: PMC2681010; DOI: 10.1016/j.ajhg.2009.04.006;

Wilk JB, Chen TH, Gottlieb DJ, Walter RE, Nagle MW, Brandler BJ, Myers RH, Borecki IB, Silverman EK, Weiss ST, O'Connor GT. A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet. 2009 Mar; 5(3):e1000429.View Related Profiles.

O'Connor, George
Myers, Richard
Chen, Ting-hsu

PMID: 19300500; PMCID: PMC2652834; DOI: 10.1371/journal.pgen.1000429;

O'Connor GT, Caffo B, Newman AB, Quan SF, Rapoport DM, Redline S, Resnick HE, Samet J, Shahar E. Prospective study of sleep-disordered breathing and hypertension: the Sleep Heart Health Study. Am J Respir Crit Care Med. 2009 Jun 15; 179(12):1159-64. PMID: 19264976; PMCID: PMC2695498; DOI: 10.1164/rccm.200712-1809OC;

Coogan PF, Palmer JR, O'Connor GT, Rosenberg L. Body mass index and asthma incidence in the Black Women's Health Study. J Allergy Clin Immunol. 2009 Jan; 123(1):89-95.View Related Profiles.

O'Connor, George
Palmer, Julie
Rosenberg, Lynn
Coogan, Patricia

PMID: 18980776; PMCID: PMC2703182; DOI: 10.1016/j.jaci.2008.09.040;

Szefler SJ, Mitchell H, Sorkness CA, Gergen PJ, O'Connor GT, Morgan WJ, Kattan M, Pongracic JA, Teach SJ, Bloomberg GR, Eggleston PA, Gruchalla RS, Kercsmar CM, Liu AH, Wildfire JJ, Curry MD, Busse WW. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet. 2008 Sep 20; 372(9643):1065-72. PMID: 18805335; PMCID: PMC2610850; DOI: 10.1016/S0140-6736(08)61448-8;

O'Connor GT, Neas L, Vaughn B, Kattan M, Mitchell H, Crain EF, Evans R, Gruchalla R, Morgan W, Stout J, Adams GK, Lippmann M. Acute respiratory health effects of air pollution on children with asthma in US inner cities. J Allergy Clin Immunol. 2008 May; 121(5):1133-1139.e1. PMID: 18405952; DOI: 10.1016/j.jaci.2008.02.020;

Muindi JR, Roth MD, Wise RA, Connett JE, O'Connor GT, Ramsdell JW, Schluger NW, Romkes M, Branch RA, Sciurba FC. Pharmacokinetics and metabolism of all-trans- and 13-cis-retinoic acid in pulmonary emphysema patients. J Clin Pharmacol. 2008 Jan; 48(1):96-107. PMID: 18094222

Walter RE, Wilk JB, Larson MG, Vasan RS, Keaney JF, Lipinska I, O'Connor GT, Benjamin EJ. Systemic inflammation and COPD: the Framingham Heart Study. Chest. 2008 Jan; 133(1):19-25.View Related Profiles.

Benjamin, Emelia
O'Connor, George
Larson, Martin
Ramachandran, Vasan

PMID: 17908709

Wilk JB, Walter RE, Laramie JM, Gottlieb DJ, O'Connor GT. Framingham Heart Study genome-wide association: results for pulmonary function measures. BMC Med Genet. 2007; 8 Suppl 1:S8. PMID: 17903307; PMCID: PMC1995616; DOI: 10.1186/1471-2350-8-S1-S8;

Gottlieb DJ, O'Connor GT, Wilk JB. Genome-wide association of sleep and circadian phenotypes. BMC Med Genet. 2007; 8 Suppl 1:S9. PMID: 17903308; PMCID: PMC1995620; DOI: 10.1186/1471-2350-8-S1-S9;

Quan SF, O'Connor GT, Quan JS, Redline S, Resnick HE, Shahar E, Siscovick D, Sherrill DL. Association of physical activity with sleep-disordered breathing. Sleep Breath. 2007 Sep; 11(3):149-57. PMID: 17221274

Kraft M, Israel E, O'Connor GT. Clinical Decisions. Treatment of mild persistent asthma. N Engl J Med. 2007 May 17; 356(20):2096-100. PMID: 17507711

Cupples LA, Arruda HT, Benjamin EJ, D'Agostino RB, Demissie S, DeStefano AL, Dupuis J, Falls KM, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Kathiresan S, Kiel DP, Laramie JM, Larson MG, Levy D, Liu CY, Lunetta KL, Mailman MD, Manning AK, Meigs JB, Murabito JM, Newton-Cheh C, O'Connor GT, O'Donnell CJ, Pandey M, Seshadri S, Vasan RS, Wang ZY, Wilk JB, Wolf PA, Yang Q, Atwood LD. The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet. 2007; 8 Suppl 1:S1.View Related Profiles.

DeStefano, Anita
O'Donnell, Christopher
Liu, Chunyu
Benjamin, Emelia
O'Connor, George
Murabito, Joanne
Dupuis, Josee
Lunetta, Kathryn
Cupples, L
Larson, Martin
Heard-Costa, Nancy
Wolf, Philip
Yang, Qiong
D'Agostino, Ralph
Demissie, Serkalem
Hwang, Shih-Jen
Seshadri, Sudha
Ramachandran, Vasan

PMID: 17903291; PMCID: PMC1995613; DOI: 10.1186/1471-2350-8-S1-S1;

Roth MD, Connett JE, D'Armiento JM, Foronjy RF, Friedman PJ, Goldin JG, Louis TA, Mao JT, Muindi JR, O'Connor GT, Ramsdell JW, Ries AL, Scharf SM, Schluger NW, Sciurba FC, Skeans MA, Walter RE, Wendt CH, Wise RA. Feasibility of retinoids for the treatment of emphysema study. Chest. 2006 Nov; 130(5):1334-45. PMID: 17099008

Kattan M, Crain EF, Steinbach S, Visness CM, Walter M, Stout JW, Evans R, Smartt E, Gruchalla RS, Morgan WJ, O'Connor GT, Mitchell HE. A randomized clinical trial of clinician feedback to improve quality of care for inner-city children with asthma. Pediatrics. 2006 Jun; 117(6):e1095-103. PMID: 16740812

O'Connor GT. Safety of long-acting beta-agonists. N Engl J Med. 2006 Mar 16; 354(11):1206-8; author reply 1206-8. PMID: 16548074

Burkart KM, Barton SJ, Holloway JW, Yang IA, Cakebread JA, Cruikshank W, Little F, Jin X, Farrer LA, Clough JB, Keith TP, Holgate S, Center DM, O'Connor GT. Association of asthma with a functional promoter polymorphism in the IL16 gene. J Allergy Clin Immunol. 2006 Jan; 117(1):86-91.View Related Profiles.

Center, David
Little, Frederic
O'Connor, George
Farrer, Lindsay
Cruikshank, William

PMID: 16387589

Kattan M, Stearns SC, Crain EF, Stout JW, Gergen PJ, Evans R, Visness CM, Gruchalla RS, Morgan WJ, O'Connor GT, Mastin JP, Mitchell HE. Cost-effectiveness of a home-based environmental intervention for inner-city children with asthma. J Allergy Clin Immunol. 2005 Nov; 116(5):1058-63. PMID: 16275376

Redline S, Min NI, Shahar E, Rapoport D, O'Connor G. Polysomnographic predictors of blood pressure and hypertension: is one index best? Sleep. 2005 Sep; 28(9):1122-30. PMID: 16268382

O'Connor GT. Allergen avoidance in asthma: what do we do now? J Allergy Clin Immunol. 2005 Jul; 116(1):26-30. PMID: 15990768

Fass R, Quan SF, O'Connor GT, Ervin A, Iber C. Predictors of heartburn during sleep in a large prospective cohort study. Chest. 2005 May; 127(5):1658-66. PMID: 15888843

Levy AP, Zhang L, Miller-Lotan R, Redline S, O'Connor GT, Quan SF, Resnick HE. Haptoglobin phenotype, sleep-disordered breathing, and the prevalence of cardiovascular disease: the Sleep Heart Health Study. Sleep. 2005 Feb; 28(2):207-13. PMID: 16171245

Morgan WJ, Crain EF, Gruchalla RS, O'Connor GT, Kattan M, Evans R, Stout J, Malindzak G, Smartt E, Plaut M, Walter M, Vaughn B, Mitchell H. Results of a home-based environmental intervention among urban children with asthma. N Engl J Med. 2004 Sep 9; 351(11):1068-80. PMID: 15356304

O'connor GT, Walter M, Mitchell H, Kattan M, Morgan WJ, Gruchalla RS, Pongracic JA, Smartt E, Stout JW, Evans R, Crain EF, Burge HA. Airborne fungi in the homes of children with asthma in low-income urban communities: The Inner-City Asthma Study. J Allergy Clin Immunol. 2004 Sep; 114(3):599-606. PMID: 15356564

Walsleben JA, Kapur VK, Newman AB, Shahar E, Bootzin RR, Rosenberg CE, O'Connor G, Nieto FJ. Sleep and reported daytime sleepiness in normal subjects: the Sleep Heart Health Study. Sleep. 2004 Mar 15; 27(2):293-8. PMID: 15124725

Miller RR, Zhang Y, Silliman RA, Hayes MK, Leveille SG, Murabito JM, Kiel D, O'Connor GT, Felson DT. Effect of medical conditions on improvement in self-reported and observed functional performance of elders. J Am Geriatr Soc. 2004 Feb; 52(2):217-23.View Related Profiles.

Felson, David
O'Connor, George
Murabito, Joanne
Silliman, Rebecca
Zhang, Yuqing

PMID: 14728630

Wilk JB, DeStefano AL, Joost O, Myers RH, Cupples LA, Slater K, Atwood LD, Heard-Costa NL, Herbert A, O'Connor GT, Gottlieb DJ. Linkage and association with pulmonary function measures on chromosome 6q27 in the Framingham Heart Study. Hum Mol Genet. 2003 Nov 1; 12(21):2745-51.View Related Profiles.

Herbert, Alan
DeStefano, Anita
O'Connor, George
Cupples, L
Heard-Costa, Nancy
Myers, Richard

PMID: 12966033

Wallace LA, Mitchell H, O'Connor GT, Neas L, Lippmann M, Kattan M, Koenig J, Stout JW, Vaughn BJ, Wallace D, Walter M, Adams K, Liu LJ. Particle concentrations in inner-city homes of children with asthma: the effect of smoking, cooking, and outdoor pollution. Environ Health Perspect. 2003 Jul; 111(9):1265-72. PMID: 12842784; PMCID: PMC1241585

Litonjua AA, Sparrow D, Guevarra L, O'Connor GT, Weiss ST, Tollerud DJ. Serum interferon-gamma is associated with longitudinal decline in lung function among asthmatic patients: the Normative Aging Study. Ann Allergy Asthma Immunol. 2003 Apr; 90(4):422-8.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 12722965

Walter RE, Beiser A, Givelber RJ, O'Connor GT, Gottlieb DJ. Association between glycemic state and lung function: the Framingham Heart Study. Am J Respir Crit Care Med. 2003 Mar 15; 167(6):911-6.View Related Profiles.

Beiser, Alexa
O'Connor, George

PMID: 12623860

O'Connor GT, Lind BK, Lee ET, Nieto FJ, Redline S, Samet JM, Boland LL, Walsleben JA, Foster GL. Variation in symptoms of sleep-disordered breathing with race and ethnicity: the Sleep Heart Health Study. Sleep. 2003 Feb 1; 26(1):74-9. PMID: 12627736

Shahar E, Redline S, Young T, Boland LL, Baldwin CM, Nieto FJ, O'Connor GT, Rapoport DM, Robbins JA. Hormone replacement therapy and sleep-disordered breathing. Am J Respir Crit Care Med. 2003 May 1; 167(9):1186-92. PMID: 12531779

Sanders MH, Newman AB, Haggerty CL, Redline S, Lebowitz M, Samet J, O'Connor GT, Punjabi NM, Shahar E. Sleep and sleep-disordered breathing in adults with predominantly mild obstructive airway disease. Am J Respir Crit Care Med. 2003 Jan 1; 167(1):7-14. PMID: 12502472

Crain EF, Walter M, O'Connor GT, Mitchell H, Gruchalla RS, Kattan M, Malindzak GS, Enright P, Evans R, Morgan W, Stout JW. Home and allergic characteristics of children with asthma in seven U.S. urban communities and design of an environmental intervention: the Inner-City Asthma Study. Environ Health Perspect. 2002 Sep; 110(9):939-45. PMID: 12204830; PMCID: PMC1240995

Kapur V, Strohl KP, Redline S, Iber C, O'Connor G, Nieto J. Underdiagnosis of sleep apnea syndrome in U.S. communities. Sleep Breath. 2002 Jun; 6(2):49-54. PMID: 12075479

Joost O, Wilk JB, Cupples LA, Harmon M, Shearman AM, Baldwin CT, O'Connor GT, Myers RH, Gottlieb DJ. Genetic loci influencing lung function: a genome-wide scan in the Framingham Study. Am J Respir Crit Care Med. 2002 Mar 15; 165(6):795-9.View Related Profiles.

Baldwin, Clinton
O'Connor, George
Cupples, L
Myers, Richard

PMID: 11897646

Gottlieb DJ, Wilk JB, Harmon M, Evans JC, Joost O, Levy D, O'Connor GT, Myers RH. Heritability of longitudinal change in lung function. The Framingham study. Am J Respir Crit Care Med. 2001 Nov 1; 164(9):1655-9.View Related Profiles.

Levy, Daniel
O'Connor, George
Myers, Richard

PMID: 11719305

Guidry UC, Mendes LA, Evans JC, Levy D, O'Connor GT, Larson MG, Gottlieb DJ, Benjamin EJ. Echocardiographic features of the right heart in sleep-disordered breathing: the Framingham Heart Study. Am J Respir Crit Care Med. 2001 Sep 15; 164(6):933-8.View Related Profiles.

Benjamin, Emelia
O'Connor, George
Larson, Martin

PMID: 11587973

Vojta PJ, Randels SP, Stout J, Muilenberg M, Burge HA, Lynn H, Mitchell H, O'Connor GT, Zeldin DC. Effects of physical interventions on house dust mite allergen levels in carpet, bed, and upholstery dust in low-income, urban homes. Environ Health Perspect. 2001 Aug; 109(8):815-9. PMID: 11564617; PMCID: PMC1240409

Baldwin CM, Griffith KA, Nieto FJ, O'Connor GT, Walsleben JA, Redline S. The association of sleep-disordered breathing and sleep symptoms with quality of life in the Sleep Heart Health Study. Sleep. 2001 Feb 1; 24(1):96-105. PMID: 11204058

Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Nieto FJ, O'Connor GT, Boland LL, Schwartz JE, Samet JM. Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study. Am J Respir Crit Care Med. 2001 Jan; 163(1):19-25. PMID: 11208620

Finkelstein J, O'Connor G, Friedmann RH. Development and implementation of the home asthma telemonitoring (HAT) system to facilitate asthma self-care. Stud Health Technol Inform. 2001; 84(Pt 1):810-4. PMID: 11604847

Walter R, Gottlieb DJ, O'Connor GT. Environmental and genetic risk factors and gene-environment interactions in the pathogenesis of chronic obstructive lung disease. Environ Health Perspect. 2000 Aug; 108 Suppl 4:733-42. PMID: 10931792; PMCID: PMC1637681

O'Connor GT, Sparrow D, Demolles D, Dockery D, Raizenne M, Fay M, Ingram RH, Speizer FE. Maximal and partial expiratory flow rates in a population sample of 10- to 11-yr-old schoolchildren. Effect of volume history and relation to asthma and maternal smoking. Am J Respir Crit Care Med. 2000 Aug; 162(2 Pt 1):436-9.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 10934066

Kitch BT, Chew G, Burge HA, Muilenberg ML, Weiss ST, Platts-Mills TA, O'Connor G, Gold DR. Socioeconomic predictors of high allergen levels in homes in the greater Boston area. Environ Health Perspect. 2000 Apr; 108(4):301-7. PMID: 10753087; PMCID: PMC1638021

Allaire SH, LaValley MP, Evans SR, O'Connor GT, Kelly-Hayes M, Meenan RF, Levy D, Felson DT. Evidence for decline in disability and improved health among persons aged 55 to 70 years: the Framingham Heart Study. Am J Public Health. 1999 Nov; 89(11):1678-83.View Related Profiles.

Felson, David
O'Connor, George
Kelly-Hayes, Margaret
LaValley, Michael
Meenan, Robert
Allaire, Saralynn

PMID: 10553388; PMCID: PMC1508997

Chang B, Ryan D, Kennedy S, O'Connor G. Orbital Kimura's disease in a white child. Br J Ophthalmol. 1999 Oct; 83(10):1198-9. PMID: 10636650; PMCID: PMC1722804

Powell CA, Klares S, O'Connor G, Brody JS. Loss of heterozygosity in epithelial cells obtained by bronchial brushing: clinical utility in lung cancer. Clin Cancer Res. 1999 Aug; 5(8):2025-34.View Related Profiles.

O'Connor, George
Brody, Jerome

PMID: 10473082

O'Connor GT, Gold DR. Cockroach allergy and asthma in a 30-year-old man. Environ Health Perspect. 1999 Mar; 107(3):243-7. PMID: 10064555; PMCID: PMC1566372

Weiss ST, O'Connor GT, DeMolles D, Platts-Mills T, Sparrow D. Indoor allergens and longitudinal FEV1 decline in older adults: the Normative Aging Study. J Allergy Clin Immunol. 1998 Jun; 101(6 Pt 1):720-5.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 9648697

Givelber RJ, Couropmitree NN, Gottlieb DJ, Evans JC, Levy D, Myers RH, O'Connor GT. Segregation analysis of pulmonary function among families in the Framingham Study. Am J Respir Crit Care Med. 1998 May; 157(5 Pt 1):1445-51.View Related Profiles.

O'Connor, George
Myers, Richard

PMID: 9603122

Quan SF, Howard BV, Iber C, Kiley JP, Nieto FJ, O'Connor GT, Rapoport DM, Redline S, Robbins J, Samet JM, Wahl PW. The Sleep Heart Health Study: design, rationale, and methods. Sleep. 1997 Dec; 20(12):1077-85. PMID: 9493915

Litonjua AA, Sparrow D, Weiss ST, O'Connor GT, Long AA, Ohman JL. Sensitization to cat allergen is associated with asthma in older men and predicts new-onset airway hyperresponsiveness. The Normative Aging Study. Am J Respir Crit Care Med. 1997 Jul; 156(1):23-7.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 9230721

Sparrow D, O'Connor GT, Weiss ST, DeMolles D, Ingram RH. Volume history effects and airway responsiveness in middle-aged and older men. The Normative Aging Study. Am J Respir Crit Care Med. 1997 Mar; 155(3):888-92.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 9117022

Gottlieb DJ, Stone PJ, Sparrow D, Gale ME, Weiss ST, Snider GL, O'Connor GT. Urinary desmosine excretion in smokers with and without rapid decline of lung function: the Normative Aging Study. Am J Respir Crit Care Med. 1996 Nov; 154(5):1290-5.View Related Profiles.

Sparrow, David
O'Connor, George
Stone, Phillip

PMID: 8912738

Shadick NA, Sparrow D, O'Connor GT, DeMolles D, Weiss ST. Relationship of serum IgE concentration to level and rate of decline of pulmonary function: the Normative Aging Study. Thorax. 1996 Aug; 51(8):787-92.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 8795665; PMCID: PMC472538

Gottlieb DJ, Sparrow D, O'Connor GT, Weiss ST. Skin test reactivity to common aeroallergens and decline of lung function. The Normative Aging Study. Am J Respir Crit Care Med. 1996 Feb; 153(2):561-6.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 8564098

Cunningham J, O'Connor GT, Dockery DW, Speizer FE. Environmental tobacco smoke, wheezing, and asthma in children in 24 communities. Am J Respir Crit Care Med. 1996 Jan; 153(1):218-24. PMID: 8542119

Gottlieb DJ, Beiser AS, O'Connor GT. Poverty, race, and medication use are correlates of asthma hospitalization rates. A small area analysis in Boston. Chest. 1995 Jul; 108(1):28-35.View Related Profiles.

Beiser, Alexa
O'Connor, George

PMID: 7606972

O'Connor GT, Sparrow D, Weiss ST. A prospective longitudinal study of methacholine airway responsiveness as a predictor of pulmonary-function decline: the Normative Aging Study. Am J Respir Crit Care Med. 1995 Jul; 152(1):87-92.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 7599868

Stone PJ, Gottlieb DJ, O'Connor GT, Ciccolella DE, Breuer R, Bryan-Rhadfi J, Shaw HA, Franzblau C, Snider GL. Elastin and collagen degradation products in urine of smokers with and without chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1995 Apr; 151(4):952-9.View Related Profiles.

Franzblau, Carl
O'Connor, George
Stone, Phillip

PMID: 7697272

Annema JT, Sparrow D, O'Connor GT, Rijcken B, Koëter GH, Postma DS, Weiss ST. Chronic respiratory symptoms and airway responsiveness to methacholine are associated with eosinophilia in older men: the Normative Aging Study. Eur Respir J. 1995 Jan; 8(1):62-9.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 7744195

O'Connor GT, Sparrow D, Weiss ST. Normal range of methacholine responsiveness in relation to prechallenge pulmonary function. The Normative Aging Study. Chest. 1994 Mar; 105(3):661-6.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 8131522

O'Connor GT, Weiss ST. Clinical and symptom measures. Am J Respir Crit Care Med. 1994 Feb; 149(2 Pt 2):S21-8; discussion S29-30. PMID: 8298766

Sparrow D, O'Connor GT, Rosner B, Weiss ST. Predictors of longitudinal change in methacholine airway responsiveness among middle-aged and older men: the Normative Aging Study. Am J Respir Crit Care Med. 1994 Feb; 149(2 Pt 1):376-81.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 8306033

Arbeit RD, Slutsky A, Barber TW, Maslow JN, Niemczyk S, Falkinham JO, O'Connor GT, von Reyn CF. Genetic diversity among strains of Mycobacterium avium causing monoclonal and polyclonal bacteremia in patients with AIDS. J Infect Dis. 1993 Jun; 167(6):1384-90.View Related Profiles.

O'Connor, George
Barber, Thomas

PMID: 8501328

Sparrow D, O'Connor GT, Rosner B, DeMolles D, Weiss ST. A longitudinal study of plasma cortisol concentration and pulmonary function decline in men. The Normative Aging Study. Am Rev Respir Dis. 1993 Jun; 147(6 Pt 1):1345-8.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 8503543

Sparrow D, O'Connor GT, Basner RC, Rosner B, Weiss ST. Predictors of the new onset of wheezing among middle-aged and older men. The Normative Aging Study. Am Rev Respir Dis. 1993 Feb; 147(2):367-71.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 8430960

O'Connor GT, Sparrow D, Segal M, Weiss ST. Risk factors for ventilatory impairment among middle-aged and elderly men. The Normative Aging Study. Chest. 1993 Feb; 103(2):376-82.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 8432122

O'connor G. Brazil: the children of the day after. Child Worldw. 1993; 20(2-3):56-7. PMID: 12179315

Weiss ST, Sparrow D, O'Connor GT. The interrelationship among allergy, airways responsiveness, and asthma. J Asthma. 1993; 30(5):329-49.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 8407734

Bailey WC, Clark NM, Gotsch AR, Lemen RJ, O'Connor GT, Rosenstock IM. Asthma prevention. Task Force on Research and Education for the Prevention and Control of Respiratory Diseases. Chest. 1992 Sep; 102(3 Suppl):216S-231S. PMID: 1516452

Sparrow D, O'Connor GT, Young JB, Rosner B, Weiss ST. Relationship of urinary serotonin excretion to cigarette smoking and respiratory symptoms. The Normative Aging Study. Chest. 1992 Apr; 101(4):976-80.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 1372851

Tollerud DJ, O'Connor GT, Sparrow D, Weiss ST. Asthma, hay fever, and phlegm production associated with distinct patterns of allergy skin test reactivity, eosinophilia, and serum IgE levels. The Normative Aging Study. Am Rev Respir Dis. 1991 Oct; 144(4):776-81.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 1928948

Sparrow D, O'Connor GT, Rosner B, Weiss ST. Methacholine airway responsiveness and 24-hour urine excretion of sodium and potassium. The Normative Aging Study. Am Rev Respir Dis. 1991 Sep; 144(3 Pt 1):722-5.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 1892316

Sparrow D, O'Connor GT, Rosner B, Segal MR, Weiss ST. The influence of age and level of pulmonary function on nonspecific airway responsiveness. The Normative Aging Study. Am Rev Respir Dis. 1991 May; 143(5 Pt 1):978-82.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 2024853

Parker DR, O'Connor GT, Sparrow D, Segal MR, Weiss ST. The relationship of nonspecific airway responsiveness and atopy to the rate of decline of lung function. The Normative Aging Study. Am Rev Respir Dis. 1990 Mar; 141(3):589-94.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 2178525

O'Connor GT, Sparrow D, Segal MR, Weiss ST. Smoking, atopy, and methacholine airway responsiveness among middle-aged and elderly men. The Normative Aging Study. Am Rev Respir Dis. 1989 Dec; 140(6):1520-6.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 2690701

O'Connor GT, Olmstead EM, Zug K, Baughman RD, Beck JR, Dunn JL, Seal P, Lewandowski JF. Detection of hepatotoxicity associated with methotrexate therapy for psoriasis. Arch Dermatol. 1989 Sep; 125(9):1209-17. PMID: 2774596

Sorlie PD, Kannel WB, O'Connor G. Mortality associated with respiratory function and symptoms in advanced age. The Framingham Study. Am Rev Respir Dis. 1989 Aug; 140(2):379-84. PMID: 2764375

O'Connor GT, Sparrow D, Weiss ST. The role of allergy and nonspecific airway hyperresponsiveness in the pathogenesis of chronic obstructive pulmonary disease. Am Rev Respir Dis. 1989 Jul; 140(1):225-52.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 2665587

Regan-Smith MG, O'Connor GT, Kwoh CK, Brown LA, Olmstead EM, Burnett JB. Lack of correlation between the Steinbrocker staging of hand radiographs and the functional health status of individuals with rheumatoid arthritis. Arthritis Rheum. 1989 Feb; 32(2):128-33. PMID: 2920048

Spektor DM, Lippmann M, Thurston GD, Lioy PJ, Stecko J, O'Connor G, Garshick E, Speizer FE, Hayes C. Effects of ambient ozone on respiratory function in healthy adults exercising outdoors. Am Rev Respir Dis. 1988 Oct; 138(4):821-8.View Related Profiles.

Garshick, Eric
O'Connor, George

PMID: 3202456

Sparrow D, O'Connor G, Weiss ST. The relation of airways responsiveness and atopy to the development of chronic obstructive lung disease. Epidemiol Rev. 1988; 10:29-47.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 3066629

O'Connor G, Sparrow D, Taylor D, Segal M, Weiss S. Analysis of dose-response curves to methacholine. An approach suitable for population studies. Am Rev Respir Dis. 1987 Dec; 136(6):1412-7.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 3318599

Sparrow D, O'Connor G, Weiss ST. Bronchial responsiveness to methacholine: relation to respiratory symptoms and pulmonary function. Bull Eur Physiopathol Respir. 1987 Jul-Aug; 23(4):395-6.View Related Profiles.

Sparrow, David
O'Connor, George

PMID: 3318968

Sparrow D, O'Connor G, Colton T, Barry CL, Weiss ST. The relationship of nonspecific bronchial responsiveness to the occurrence of respiratory symptoms and decreased levels of pulmonary function. The Normative Aging Study. Am Rev Respir Dis. 1987 Jun; 135(6):1255-60.View Related Profiles.

Sparrow, David
O'Connor, George
Colton, Theodore

PMID: 3296893

O'Connor GT, Weiss ST, Tager IB, Speizer FE. The effect of passive smoking on pulmonary function and nonspecific bronchial responsiveness in a population-based sample of children and young adults. Am Rev Respir Dis. 1987 Apr; 135(4):800-4. PMID: 3565928

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 303 publications over 36 distinct years, with a maximum of 26 publications in 2021

Bar chart showing 303 publications over 36 distinct years, with a maximum of 26 publications in 2021

Year	Publications
1987	4
1988	2
1989	5
1990	1
1991	3
1992	2
1993	6
1994	3
1995	4
1996	4
1997	3
1998	2
1999	4
2000	3
2001	6
2002	3
2003	7
2004	4
2005	5
2006	4
2007	6
2008	4
2009	13
2010	8
2011	6
2012	10
2013	15
2014	11
2015	16
2016	20
2017	21
2018	15
2019	25
2020	17
2021	26
2022	15

Media Mentions

COPD Screening for Asymptomatic Adults? USPSTF Weighs In, Again

Medscape 5/11/2022

USPSTF finalizes recommendation against COPD screening in asymptomatic adults

Healio 5/10/2022

New asthma guidelines advise single maintenance and reliever therapy

MD Alert 12/7/2020

NHLBI Updates Asthma Tx Guidelines

MedPage Today 12/3/2020

E-Cigarettes More Effective Than Nicotine-Replacement Therapy For Smoking-Cessation

Healio 2/21/2019

Vaping twice as good as gum for quitting smoking finds study

News Medical Life Sciences 1/31/2019

Vaping 2x better for quitting smoking than patches, gum: study

Sunday Times 1/31/2019

E-Cigarettes More Effective Than Nicotine Patches, Gums In Getting People To Stop Smoking Cigarettes, Study Finds

CNBC 1/30/2019

E-Cigarettes Are Effective at Helping Smokers Quit, a Study Says

The New York Times 1/30/2019

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

air pollution
Asthma
Clinical trials
COPD
Epidemiology
Genetic epidemiology
pulmonary function
sleep apnea

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