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#Tissue_Science_Conference_2018
Don't miss out #Tissuescience2018 that will provide in-depth instruction and demonstration in #Stemcell_theraphy and #Regenerative_medicine treatments.
Check out the event: http://tissuescience.alliedacademies.com/
Register today!
#Stemcells #Tissue_repair #Bioengineering #Regenerative_medicine
Don't miss out #Tissuescience2018 that will provide in-depth instruction and demonstration in #Stemcell_theraphy and #Regenerative_medicine treatments.
Check out the event: http://tissuescience.alliedacademies.com/
Register today!
#Stemcells #Tissue_repair #Bioengineering #Regenerative_medicine
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cool aint it
Brain on a Chip” Reveals How the Brain Folds
Being born with a “tabula rasa” – a clean slate – in the case of the brain is something of a curse. Our brains are already wrinkled like walnuts by the time we are born. Babies born without these wrinkles – smooth brain syndrome – suffer from severe developmental deficiencies and their life expectancy is markedly reduced. The gene that causes this syndrome helped Weizmann Institute of Science researchers to probe the physical forces that cause the brain’s wrinkles to form. In their findings, reported in Nature Physics, the researchers describe a method they developed for growing tiny “brains on chips” from human cells that enabled them to track the physical and biological mechanisms underlying the wrinkling process.
Tiny brains grown in the lab from embryonic stem cells –called organoids – were pioneered in the last decade by Profs. Yoshiki Sasai in Japan and Juergen Knoblich in Austria. Prof. Orly Reiner of the Institute’s Molecular Genetics Department says that her lab, along with many others, embraced the idea of growing organoids. But Dr. Eyal Karzbrun, in her lab, had to put a bit of a damper on their enthusiasm: The sizes of the organoids they obtained were far from uniform; with no blood vessels, the insides did not have a steady supply of nutrients and started to die; and the thickness of the tissue got in the way of the optical imaging and microscope tracking.
So Karzbrun developed a new approach to growing organoids – one that would enable the group to follow their growth processes in real time: He limited their growth in the vertical axis. This gave him a “pita”-shaped organoid – round and flat with a thin space in the middle. This shape enabled the group to image the thin tissue as it developed and to supply nutrients to all the cells. And by the second week of the tiny “brain’s” growth and development, wrinkles began to appear and then to deepen. Karzbrun: “This is the first time that folding has been observed in organoids, apparently due to the architecture of our system.”
Wrinkles in time
Karzbrun is a physicist by training, and he naturally turned to physical models for the behavior of elastic materials to understand the formation of the wrinkles. Folds or wrinkles in a surface are the result of mechanical instability – compression forces applied to some part of the material. So for example, if there is uneven expansion in one part of the material, another part might be forced to fold in order to accommodate the pressure. In the organoids, the scientists found such mechanical instability in two places: The cytoskeleton – the internal skeleton – of the cells in the center of the organoid contracted; and the nuclei of the cells near the surface expanded. Or, to think of it another way, the outside of the “pita” grew faster than its inside.
While this achievement was impressive, Reiner was not convinced that the wrinkles in the organoids were really modeling the folds in a developing brain. So the group grew new organoids, this time bearing the same mutations carried by babies with smooth brain syndrome. Reiner had identified this gene – LIS1 – back in 1993, and has investigated its role in the developing brain and in the disease, which affects one in 30,000 births. Among other things, the gene is involved in the migration of nerve cells to the brain during embryonic development, and it also regulates the cytoskeleton and molecular motors in the cell.
The organoids with the mutated gene grew to the same proportions as the others, but they developed few folds and the ones they did develop were very different in shape from the normal wrinkles. Working on the assumption that differences in the physical properties of the cell were responsible for these variations, the group investigated the organoid’s cells with atomic force microscopy, with the help of Dr. Sidney Cohen of the Chemical Research Support Department. By measures of elasticity, the normal cells were about twice as stiff as the mutated ones, which were basically soft. Reiner: “We discovered a significant difference in the physical properties of cells in the two organoids, but we observed difference in their biological properties as well. For example, the nuclei in the centers of the mutant organoids moved more slowly, and we saw significant differences in gene expression.”
Source:
https://wis-wander.weizmann.ac.il/life-sciences/%E2%80%9Cbrain-chip%E2%80%9D-reveals-how-brain-folds
Journal article:
https://www.nature.com/articles/s41567-018-0046-7
Gif: As the organoid develops, the tissue in the outer part folds in a manner similar to those in the developing brain.
#stemcells #brainorganoids #lissencephaly #brainwrinkles #geneexpression #braindevelopment #neuroscience
Being born with a “tabula rasa” – a clean slate – in the case of the brain is something of a curse. Our brains are already wrinkled like walnuts by the time we are born. Babies born without these wrinkles – smooth brain syndrome – suffer from severe developmental deficiencies and their life expectancy is markedly reduced. The gene that causes this syndrome helped Weizmann Institute of Science researchers to probe the physical forces that cause the brain’s wrinkles to form. In their findings, reported in Nature Physics, the researchers describe a method they developed for growing tiny “brains on chips” from human cells that enabled them to track the physical and biological mechanisms underlying the wrinkling process.
Tiny brains grown in the lab from embryonic stem cells –called organoids – were pioneered in the last decade by Profs. Yoshiki Sasai in Japan and Juergen Knoblich in Austria. Prof. Orly Reiner of the Institute’s Molecular Genetics Department says that her lab, along with many others, embraced the idea of growing organoids. But Dr. Eyal Karzbrun, in her lab, had to put a bit of a damper on their enthusiasm: The sizes of the organoids they obtained were far from uniform; with no blood vessels, the insides did not have a steady supply of nutrients and started to die; and the thickness of the tissue got in the way of the optical imaging and microscope tracking.
So Karzbrun developed a new approach to growing organoids – one that would enable the group to follow their growth processes in real time: He limited their growth in the vertical axis. This gave him a “pita”-shaped organoid – round and flat with a thin space in the middle. This shape enabled the group to image the thin tissue as it developed and to supply nutrients to all the cells. And by the second week of the tiny “brain’s” growth and development, wrinkles began to appear and then to deepen. Karzbrun: “This is the first time that folding has been observed in organoids, apparently due to the architecture of our system.”
Wrinkles in time
Karzbrun is a physicist by training, and he naturally turned to physical models for the behavior of elastic materials to understand the formation of the wrinkles. Folds or wrinkles in a surface are the result of mechanical instability – compression forces applied to some part of the material. So for example, if there is uneven expansion in one part of the material, another part might be forced to fold in order to accommodate the pressure. In the organoids, the scientists found such mechanical instability in two places: The cytoskeleton – the internal skeleton – of the cells in the center of the organoid contracted; and the nuclei of the cells near the surface expanded. Or, to think of it another way, the outside of the “pita” grew faster than its inside.
While this achievement was impressive, Reiner was not convinced that the wrinkles in the organoids were really modeling the folds in a developing brain. So the group grew new organoids, this time bearing the same mutations carried by babies with smooth brain syndrome. Reiner had identified this gene – LIS1 – back in 1993, and has investigated its role in the developing brain and in the disease, which affects one in 30,000 births. Among other things, the gene is involved in the migration of nerve cells to the brain during embryonic development, and it also regulates the cytoskeleton and molecular motors in the cell.
The organoids with the mutated gene grew to the same proportions as the others, but they developed few folds and the ones they did develop were very different in shape from the normal wrinkles. Working on the assumption that differences in the physical properties of the cell were responsible for these variations, the group investigated the organoid’s cells with atomic force microscopy, with the help of Dr. Sidney Cohen of the Chemical Research Support Department. By measures of elasticity, the normal cells were about twice as stiff as the mutated ones, which were basically soft. Reiner: “We discovered a significant difference in the physical properties of cells in the two organoids, but we observed difference in their biological properties as well. For example, the nuclei in the centers of the mutant organoids moved more slowly, and we saw significant differences in gene expression.”
Source:
https://wis-wander.weizmann.ac.il/life-sciences/%E2%80%9Cbrain-chip%E2%80%9D-reveals-how-brain-folds
Journal article:
https://www.nature.com/articles/s41567-018-0046-7
Gif: As the organoid develops, the tissue in the outer part folds in a manner similar to those in the developing brain.
#stemcells #brainorganoids #lissencephaly #brainwrinkles #geneexpression #braindevelopment #neuroscience
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Exercise is important - not only for your overall health, but for your joints, too. However, if your joints are stiff or achy, getting in your daily exercise can be difficult. Don't be held back! Consider stem cell therapy, a revolutionary new treatment that helps patients get back to their life with no downtime. Get back to your daily routine with the help of stem cells! https://drburkeortho.com/specialties/stem-cell-therapy #stemcells #stemcelltherapy #workout #exercise #joints #orthopedics
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Mention this posting for specials!
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Laser treatment for varicose veins or EVLT, uses an ultra-fine fiber placed with an IV into the greater saphenous vein. Computerized laser energy is used to denature the veins inner cell layer and cause the vein to collapse and close. This particular laser treatment for varicose veins eliminates the “reflux” flow and thus the cause of the problem.
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NOW we are offering 50% off a vein treatment from Sept. 1st to Sept 30th. It will be good for all vein treatments for varicose veins & spider veins, including:
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NOW we are offering 50% off a vein treatment from Sept. 1st to Sept 30th. It will be good for all vein treatments for varicose veins & spider veins, including:
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• EVLT (Endovenous Laser Therapy)
• Foam Sclerotherapy
• Compression Therapy
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Call us at 302-858-4880, we'll help you look and feel the best!
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#veinTreatments #sclerotherapy #endovenousLaserTreatment #FoamSclerotherapy #CompressionTherapy
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Stem Cell Procedure
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How long it will take?
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Depending on the individualized treatment plan, the initial treatment can take 2 hours. Once you have a consultation, we can be more specific as to the time frame required for your treatment.
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#sportsInjury #painManagement #wristInjury #golfInjuries #jointPain
#hippain #kneepain #backPain #anklePain #PRP #stemcells #antiagingMedicine
#Delaware #Virginia #Pennsylvania #Maryland #regenerativeMedicine #nonSurgical
#DrChilders #weMightHelp #RegenerativeMedicalCenterOfDelaware
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How long it will take?
.
Depending on the individualized treatment plan, the initial treatment can take 2 hours. Once you have a consultation, we can be more specific as to the time frame required for your treatment.
.
Call us at (302)858-4880, to find out if you’re a candidate for stem cell therapy, and how it can benefit you.
.
#sportsInjury #painManagement #wristInjury #golfInjuries #jointPain
#hippain #kneepain #backPain #anklePain #PRP #stemcells #antiagingMedicine
#Delaware #Virginia #Pennsylvania #Maryland #regenerativeMedicine #nonSurgical
#DrChilders #weMightHelp #RegenerativeMedicalCenterOfDelaware
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Stem Cell Procedure
.
Will I be awake?
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Yes. There is no general sedation or narcotics, just local anesthesia. This is a big advantage over the health risks associated with general anesthesia and surgery.
.
Call us at (302)858-4880, to find out if you’re a candidate for stem cell therapy, and how it can benefit you.
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#sportsInjury #painManagement #wristInjury #golfInjuries #jointPain
#hippain #kneepain #backPain #anklePain #PRP #stemcells #antiagingMedicine
#Delaware #Virginia #Pennsylvania #Maryland #regenerativeMedicine #nonSurgical
#DrChilders #weMightHelp #RegenerativeMedicalCenterOfDelaware
.
Will I be awake?
.
Yes. There is no general sedation or narcotics, just local anesthesia. This is a big advantage over the health risks associated with general anesthesia and surgery.
.
Call us at (302)858-4880, to find out if you’re a candidate for stem cell therapy, and how it can benefit you.
.
#sportsInjury #painManagement #wristInjury #golfInjuries #jointPain
#hippain #kneepain #backPain #anklePain #PRP #stemcells #antiagingMedicine
#Delaware #Virginia #Pennsylvania #Maryland #regenerativeMedicine #nonSurgical
#DrChilders #weMightHelp #RegenerativeMedicalCenterOfDelaware
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Email Us - [email protected]
Call Now - +971 4 344 1132
Fax - +971 4 344 1089
#prp #prpdubai #stemcells #prptreatment #prpinjections #prptherapy
Call Now - +971 4 344 1132
Fax - +971 4 344 1089
#prp #prpdubai #stemcells #prptreatment #prpinjections #prptherapy
Stem Cell Treatment – Best Answer to Neuro-Spinal Conditions
montrealintclinic.strikingly.com
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We must manage health at the cellular level. Drugs are simply a cloak to disguise the real problem.
#cellularhealth #stemcells
#cellularhealth #stemcells
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These "unproven" treatments, the study claims, are often advertised "in a manner that inadequately discloses risks" while the treatments themselves "have not been approved by Health Canada...": http://ow.ly/j6ec30lYSm9 #medicalmalpractice #stemcells
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