File:ΔFosB.svg

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Original file ‎(SVG file, nominally 935 × 965 pixels, file size: 238 KB)

Summary[edit]

Description
English: The finished, wikilink annotated version is currently located at en:Template:Psychostimulant addiction; a more detailed image caption is located there as well.
For external (off-wiki) use, a screenshot of the annotated version is located at File:Annotated ΔFosB.svg screenshot.png.

This image shows the signal transduction that occurs in nucleus accumbens D1-type medium spiny neurons that gives rise to psychostimulant addiction. This signaling cascade occurs during chronic high-dose use of certain dopaminergic stimulants (e.g., phenethylamine, methamphetamine, amphetamine, etc). Cocaine induces a different cascade than the one shown here.

Image references
For comparison: KEGG Pathway – human cocaine addiction
  • The effect of DA receptors 3,4, and 5 on this cascade is referenced in this review.
  • The phosphorylation of CREB through the CAMK branch is referenced in figure 2 from this review.
  • The use of JunD (instead of Jun, which KEGG uses) in the annotated template is based upon figure 4 from this review.


An analogous signal transduction pathway in the NAcc is covered in this 2015 methamphetamine review and is illustrated in figure 1.
Date
Source Own work
Author Seppi333
Other versions

File:Annotated ΔFosB.svg screenshot.png - labeled version
Associated ΔFosB
expression graph		 File:ΔFosB accumulation.svg – shows how ΔFosB is induced following acute and repeated drug exposure and how it accumulates in neurons with repeated exposure to addictive drugs.
Presynaptic diagram File:TAAR1 Dopamine.svg – illustrates the other side of the synaptic cleft for amphetamine and endogenous phenethylamine.
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 This vector image was created with Inkscape.

Licensing[edit]

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Annotations This image is annotated: View the annotations at Commons

File history

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Date/TimeThumbnailDimensionsUserComment
current19:41, 9 November 2016Thumbnail for version as of 19:41, 9 November 2016935 × 965 (238 KB)Seppi333 (talk | contribs)added 1 gene product box for AC in the cAMP pathway
23:29, 21 July 2014Thumbnail for version as of 23:29, 21 July 2014935 × 965 (238 KB)Seppi333 (talk | contribs)g protein color
23:15, 21 July 2014Thumbnail for version as of 23:15, 21 July 2014935 × 965 (238 KB)Seppi333 (talk | contribs)changes to membrane structures
00:53, 21 July 2014Thumbnail for version as of 00:53, 21 July 2014935 × 965 (223 KB)Seppi333 (talk | contribs)last recoloring
00:02, 21 July 2014Thumbnail for version as of 00:02, 21 July 2014935 × 965 (228 KB)Seppi333 (talk | contribs)+1 upload
23:46, 20 July 2014Thumbnail for version as of 23:46, 20 July 2014935 × 965 (228 KB)Seppi333 (talk | contribs)Reverted to version as of 04:45, 20 July 2014
23:45, 20 July 2014Thumbnail for version as of 23:45, 20 July 2014935 × 965 (229 KB)Seppi333 (talk | contribs)recolor
23:34, 20 July 2014Thumbnail for version as of 23:34, 20 July 2014935 × 965 (228 KB)Seppi333 (talk | contribs)recolor
23:22, 20 July 2014Thumbnail for version as of 23:22, 20 July 2014935 × 965 (228 KB)Seppi333 (talk | contribs)tweaks and color coding
04:45, 20 July 2014Thumbnail for version as of 04:45, 20 July 2014935 × 965 (228 KB)Seppi333 (talk | contribs)wider boxes for sirt1/hdac1 again
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