May 13, 2016
Image credit: Cloudtail the Snow Leopard/ Flickr
05/13/2016
Research article
Scholes et al. use atomistic accelerated molecular dynamics (aMD) simulations to study the conformational changes of the GCN4 AD and variants thereof, either free in solution, or bound to the GAL11 coactivator surface. They show that the AD-coactivator interactions are highly dynamic while obeying distinct rules.
Image credit: Scholes et al.
Current Issue April 2016
05/18/2016
Research article
Merel et al. show a unification of closed-loop decoder learning setting as an imitation learning problem. This has two major consequences: first, their approach clarifies how to derive “intention-based” algorithms for any BCI setting, most notably more complex settings like control of an arm; and second, this framework allows them to provide theoretical results, building from an existing literature on the regret of related algorithms.
Image credit: Josh Merel et al.
05/13/2016
MESSAGE FROM ISCB
The Curriculum Task Force (CTF) of ISCB’s Education Committee seeks to define curricular guidelines for those who educate or train bioinformatics professionals at all career stages. A recent report of the CTF presented a draft set of bioinformatics core competencies, derived from the results of surveys of core facility directors, career opportunities, and existing curricula.
05/19/2016
research article
Using a combination of microscale cell patterning and computational modeling, Sun et al. elucidate the architecture-dependent calcium signaling and contractility in endothelial cells via gap junction mediated calcium oscillation in an architecture-dependent manner.
Image credit: Sun et al.
05/13/2016
research article
Humans employ a high degree of redundancy in joint actuation, with different combinations of muscle and tendon action providing the same net joint torque. Markowitz and Herr posit that the muscle-tendon morphology of the human leg has evolved to maximize the metabolic efficiency of walking at self-selected speed.
Image credit: Thomas Hawk/ Flickr
05/09/2016
research article
Timme et al. record the electrical activity of hundreds of neurons simultaneously in brain tissue from mice and and analyze these signals using state-of-the-art tools from information theory. These tools allow the authors to ascertain which neurons were transmitting information to other neurons and to characterize the computations performed by neurons using the inputs they received from two or more other neurons.
Image credit: ZEISS Microscopy/ Flickr
02/13/2013
BLAST FROM THE PAST
Zhang et al. examine the human spermine synthase (HsSMS).
Image credit: Zhang et al.
Image credit: AJC/ Flickr
02/24/2016
PLOS Science wednesday
Florian Markowetz and James Breton discuss their PLOS Medicine paper showing that resistance to cancer treatment may be related to the heterogeneity in the tumor, which has implications for drug effectiveness.
Image credit: Schwarz et al.
Image credit: Twitter
Addresses the ethical challenges that accompany the use of “big data” in biology and medicine.
A collection that aims to increase the coverage of computational biology topics on Wikipedia by rewarding authors with a citable, PubMed-indexed static version of the living document on Wikipedia.
Highlighting some of the latest advancements in computational treatments of macromolecules.
This collection is designed to document the progress of the ISCB Student Council, instruct others on planning activities, and encourage students to build and maintain a thriving student community.
"Ten Simple Rules" articles provide a quick, concentrated guide for mastering some of the professional challenges research scientists face in their careers.
Tracking Resilience to Infections by Mapping Disease Space
Between Pleasure and Contentment: Evolutionary Dynamics of Some Possible Parameters of Happiness
Characterization of Calflagin, a Flagellar Calcium-Binding Protein from Trypanosoma congolense
An Indel Polymorphism in the MtnA 3' Untranslated Region Is Associated with Gene Expression Variation and Local Adaptation in Drosophila melanogaster
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