International Journal of Biological Sciences

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau, Macau SAR, China

Editor-in-Chief's Profile

Impact factor is 3.873 (five year impact factor 4.689) according to 2017 release of Journal Citation Reports®. Congratulations!

Cover suggestion ...details

Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus (full index information)
Full texts of articles in PubMed Central, Europe PMC, and PMC Canada.
(For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.

Most Cited Paper Award: Winners of this year are Yan-Cun Liu, Xian-Biao Zou, Yan-Fen Chai, Yong-Ming Yao, for the paper "Macrophage Polarization in Inflammatory Diseases". Details...

Special Issue on Computational Resources and Methods in Biological Sciences. Guest editors:
Prof. Jian Huang, Dr. Hao Lin, Prof. Shaoliang Peng.

The new Faculty of Health Sciences in University of Macau is recruiting Chair and Distinguished Professors, Full and Associate Professors, and Assistant Professors. ...full details

Top cited papers:

G Chen et al. TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation. Cited by 237
BF Zamarron & W Chen. Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression. Cited by 172
TM Thornton & M Rincon. Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival. Cited by 200
HB Shao et al. Primary antioxidant free radical scavenging and redox signaling pathways in higher plant cells. Cited by 247
JK Lunney. Advances in Swine Biomedical Model Genomics. Cited by 255
DP Siderovski & FS Willard. The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Cited by 241

Special issue “Androgens and androgen receptor (AR) in prostate cancer” provides an update on different biological and clinical aspects of adrenal androgens, androgen biosynthetic pathways, AR-signaling, inter-racial differences in AR mutations, and clinical success and failure of antiandrogens and anti-AR therapies in prostate cancer. Androgen receptor, a nuclear steroid receptor and transcription factor, has a central role in the normal growth and development of the prostate gland, in prostate carcinogenesis, and in the castrate-resistant (CR) progression of PCa. Understanding the critical molecular events that lead PCa cells to resist antiandrogens or anti-AR therapies is essential in developing successful treatments for CR or advanced stages of the disease. ...

The synthetic cannabinoid WIN 55,212-2 is a potent cannabinoid receptor agonist with anticancer potential. Experiments were performed to determine the effects of WIN on proliferation, cell cycle distribution, and programmed cell death in human osteosarcoma MG63 and Saos-2 cells. Results show that WIN induced G2/M cell cycle arrest, which was associated with the induction of the main markers of ER stress (GRP78, CHOP and TRB3). ....details

Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans ...details

Vγ9Vδ2 (also termed Vγ2Vδ2) T cells, a major human peripheral blood γδ T cell subset, recognize microbial (E)-4-hydroxy-3-methylbut-2-enyl diphosphate and endogenous isopentenyl diphosphate in a TCR-dependent manner. The recognition does not require specific accessory cells, antigen uptake, antigen processing, or MHC class I, class II, or class Ib expression. This subset of T cells plays important roles in mediating innate immunity against a wide variety of infections and displays potent and broad cytotoxic activity against human tumor cells. ... ...details

The behaviour of the desert locust, Schistocera gregaria, is largely directed by volatile olfactory cues. The relevant odorants are detected by specialized antennal sensory neurons which project their sensory dendrites into hair-like structures, the sensilla. Generally, the responsiveness of the antennal chemosensory cells is determined by specific receptors which may be either odorant receptors (ORs) or variant ionotropic receptors (IRs). Previously, we demonstrated that in locust the co-receptor for ORs (ORco) is only expressed in cells of sensilla basiconica and sensilla trichodea, suggesting that cells in sensilla coeloconica may express different types of chemosensory receptors. ...details

Research Paper
Human Papillomavirus Types 16 and 18 Early-expressed Proteins Differentially Modulate the Cellular Redox State and DNA Damage
Alfredo Cruz-Gregorio, Joaquín Manzo-Merino, María Cecilia Gonzaléz-García, José Pedraza-Chaverri, Omar Noel Medina-Campos, Mahara Valverde, Emilio Rojas, María Alexandra Rodríguez-Sastre, Claudia María García-Cuellar, Marcela Lizano
Int. J. Biol. Sci. 2018; 14(1): 21-35. doi:10.7150/ijbs.21547
[Abstract] [Full text] [PDF]

Research Paper
Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice
Herui Wang, Chi Zhang, Xiaowen Wang, Yaru Lian, Bin Guo, Miao Han, Xiaoe Zhang, Xiaoting Zhu, Sixian Xu, Zengli Guo, Yunli Bi, Qian Shen, Xiang Wang, Jiaojiao Liu, Yuan Zhuang, Ting Ni, Hong Xu, Xiaohui Wu
Int. J. Biol. Sci. 2018; 14(1): 10-20. doi:10.7150/ijbs.22768
[Abstract] [Full text] [PDF]

Research Paper
Vital Roles of β-catenin in Trans-differentiation of Chondrocytes to Bone Cells
Yan Jing, Junjun Jing, Ke Wang, Kevin Chan, Stephen E. Harris, Robert J. Hinton, Jian Q. Feng
Int. J. Biol. Sci. 2018; 14(1): 1-9. doi:10.7150/ijbs.23165
[Abstract] [Full text] [PDF]

Research Paper
Metformin Sensitizes Non-small Cell Lung Cancer Cells to an Epigallocatechin-3-Gallate (EGCG) Treatment by Suppressing the Nrf2/HO-1 Signaling Pathway
Chenxiao Yu, Yang Jiao, Jiao Xue, Qi Zhang, Hongying Yang, Ligang Xing, Guangxia Chen, Jinchang Wu, Shuyu Zhang, Wei Zhu, Jianping Cao
Int. J. Biol. Sci. 2017; 13(12): 1560-1569. doi:10.7150/ijbs.18830
[Abstract] [Full text] [PDF]

Research Paper
Oxygen Supplementation Ameliorates Tibial Development via Stimulating Vascularization in Tibetan Chickens at High Altitudes
Shucheng Huang, Xiaole Tong, Mujeeb Ur Rehman, Meng Wang, Lihong Zhang, Lei Wang, Jiakui Li, Shijin Yang
Int. J. Biol. Sci. 2017; 13(12): 1547-1559. doi:10.7150/ijbs.22670
[Abstract] [Full text] [PDF]

Research Paper
Specific Deletion of β-Catenin in Col2-Expressing Cells Leads to Defects in Epiphyseal Bone
Tingyu Wang, Jun Li, Guang-Qian Zhou, Peter Ma, Yue Zhao, Baoli Wang, Di Chen
Int. J. Biol. Sci. 2017; 13(12): 1540-1546. doi:10.7150/ijbs.23000
[Abstract] [Full text] [PDF]

Research Paper
Azadirachtin induced apoptosis in the prothoracic gland in Bombyx mori and a pronounced Ca²⁺ release effect in Sf9 cells
Jing Zhang, Hongmei Liu, Zhipeng Sun, Jianjun Xie, Guohua Zhong, Xin Yi
Int. J. Biol. Sci. 2017; 13(12): 1532-1539. doi:10.7150/ijbs.22175
[Abstract] [Full text] [PDF]

Research Paper
Dl-3-n-butylphthalide prevents the disruption of blood-spinal cord barrier via inhibiting endoplasmic reticulum stress following spinal cord injury
Binbin Zheng, Yulong Zhou, Hongyu Zhang, Guangyong Yang, Zhenghua Hong, Dandan Han, Qingqing Wang, Zili He, Yanlong Liu, Fenzan Wu, Xie Zhang, Songlin Tong, Huazi Xu, Jian Xiao
Int. J. Biol. Sci. 2017; 13(12): 1520-1531. doi:10.7150/ijbs.21107
[Abstract] [Full text] [PDF]

Research Paper
The effect of co-transplantation of nerve fibroblasts and Schwann cells on peripheral nerve repair
Yang Wang, Dong Li, Gangyang Wang, Lulu Chen, Jun Chen, Zhangyin Liu, Zhaofeng Zhang, Hua Shen, Yuqing Jin, Zunli Shen
Int. J. Biol. Sci. 2017; 13(12): 1507-1519. doi:10.7150/ijbs.21976
[Abstract] [Full text] [PDF]

Review
Circular RNAs: A novel type of non-coding RNA and their potential implications in antiviral immunity
Man Wang, Fei Yu, Wei Wu, Yuan Zhang, Wenguang Chang, Murugavel Ponnusamy, Kun Wang, Peifeng Li
Int. J. Biol. Sci. 2017; 13(12): 1497-1506. doi:10.7150/ijbs.22531
[Abstract] [Full text] [PDF]

Review
The Molecular Mechanisms of Regulation on USP2's Alternative Splicing and the Significance of Its Products
Han-Qing Zhu, Feng-Hou Gao
Int. J. Biol. Sci. 2017; 13(12): 1489-1496. doi:10.7150/ijbs.21637
[Abstract] [Full text] [PDF]

Review
Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation Related Syndromic Craniosynostosis
Saïd C. Azoury, Sashank Reddy, Vivek Shukla, Chu-Xia Deng
Int. J. Biol. Sci. 2017; 13(12): 1479-1488. doi:10.7150/ijbs.22373
[Abstract] [Full text] [PDF]

Research Paper
CRISPR-offinder: a CRISPR guide RNA design and off-target searching tool for user-defined protospacer adjacent motif
Changzhi Zhao, Xiaoguo Zheng, Wubin Qu, Guanglei Li, Xinyun Li, Yi-Liang Miao, Xiaosong Han, Xiangdong Liu, Zhenhua Li, Yunlong Ma, Qianzhi Shao, Haiwei Li, Fei Sun, Shengsong Xie, Shuhong Zhao
Int. J. Biol. Sci. 2017; 13(12): 1470-1478. doi:10.7150/ijbs.21312
[Abstract] [Full text] [PDF]

Research Paper
Human colorectal cancer progression correlates with LOX-induced ECM stiffening
Bo Wei, Xueling Zhou, Chenghua Liang, Xiaoming Zheng, Purun Lei, Jiafeng Fang, Xiaoyan Han, Lijing Wang, Cuiling Qi, Hongbo Wei
Int. J. Biol. Sci. 2017; 13(11): 1450-1457. doi:10.7150/ijbs.21230
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Transcriptome integration analysis in hepatocellular carcinoma reveals discordant intronic miRNA-host gene pairs in expression
Yulin Sun, Fubo Ji, Mia R Kumar, Xin Zheng, Yi Xiao, Niya Liu, Jiong Shi, Linda Wong, Marshonna Forgues, Lun-Xiu Qin, Zhao-You Tang, Xiaohang Zhao, Xin Wei Wang, Junfang Ji
Int. J. Biol. Sci. 2017; 13(11): 1438-1449. doi:10.7150/ijbs.20836
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Adhesion Regulating Molecule 1 Mediates HAP40 Overexpression-Induced Mitochondrial Defects
Zih-Ning Huang, Her Min Chung, Su-Chiung Fang, Lu-Shiun Her
Int. J. Biol. Sci. 2017; 13(11): 1420-1437. doi:10.7150/ijbs.20742
[Abstract] [Full text] [PDF] [PubMed] [PMC]

More ...