On the heels of their encounter with Ghost Rider, their strangest phenomenon yet, the Agents of S.H.I.E.L.D. suddenly find themselves up against a myriad of new and ongoing threats: The anti-Inhuman Watchdogs are gaining political influence with Senator Nadeer, and uniting behind a mysterious benefactor. Meanwhile, unbeknownst to the team, Aida has kidnapped Agent May and replaced her with a Life Model Decoy. Aida's evil plans for May and the team remain a mystery.