Contents
July 2016
Vol 1, Issue 1
Vol 1, Issue 1
Editorial
- Promoting immunology: The future is here
Science Immunology will provide a broad platform for the most exciting findings in this growing field.
Perspective
- The discontinuity theory of immunity
Similar to many other biological systems, the immune system can be seen as a change-detection system.
Research Articles
- VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites
The VpreB component of the surrogate light chain serves as an invariant antigen that may affect the repertoire of antibody responses.
- Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation
Early T cell activation by recipient antigen-presenting cells cross-dressed with donor MHC antigens may initiate acute allograft rejection.
- Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies
The distinct architecture of bovine antibodies defines a unique immune diversity system.
Research Resource
- In-depth tissue profiling using multiplexed immunohistochemical consecutive staining on single slide
Multidimensional immunohistochemistry generates high-resolution snapshots of immune cells within a tumor.
About The Cover
ONLINE COVER Immunology in Motion. Shown is a color-enhanced scanning electron micrograph of a human T lymphocyte on a dendritic cell. By showcasing studies that span disciplines and technologies, Science Immunology will encourage collaborative and innovative research and provide a broad platform for the most exciting findings in this growing field. [CREDIT: David Scharf/Science Source]